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Biomedical subjects

K Hellmann

Publications and source records attributed to K Hellmann.

At least 73 records · Page 4Linked to original sources
PubMed1972

Metastases and the normalization of tumour blood vessels by ICRF 159: a new type of drug action.

Profound modification of the structure and arrangement of the blood vessels has been shown in tumours after treatment with ICRF 159. X-ray angiography, carbon black (Pelikan ink) labelling, and intravital staining with lissamine green were used to demonstrate the changes. Alteration of the morphology of the blood vessels at the edge of a tumour may affect the escape of malignant cells and the rate of blood flow (and thus the concentration of anticancer drugs) through the tumour.

Angiography↗
PubMed1970

Inhibition of metastatic spread by I.C.R.F. 159: selective deletion of a malignant characteristic.

Treatment with I.C.R.F. 159 completely inhibited metastasis formation in mice implanted with Lewis lung carcinoma at doses having little influence on the rate of growth of the primary implant. This inhibition was due to the effect of I.C.R.F. 159 on the development of blood vessels of the invading margins of the primary tumour. So far as is known, this is the first time a drug has induced a specific loss of the malignant characteristic of blood-borne tumour cell dissemination.

Animals↗