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Biomedical subjects

K Heimann

Publications and source records attributed to K Heimann.

At least 181 records · Page 10Linked to original sources
PubMed1988

[Early vitrectomy with primary silicone oil injection in very severely injured eyes].

Performing early vitrectomy with primary silicone oil filling in 11 severely injured eyes (large or multiple intraocular foreign bodies, double perforations, ruptures - all with vitreous hemorrhage and retinal detachment), the authors succeeded in treating the posterior segment trauma with adequate hemostasis in ten cases. During postoperative follow-up of between 12 and 39 months there were no recurrences of hemorrhage. Primary retinal reattachment was achieved in seven eyes. A traction detachment due to proliferative vitreoretinopathy developed in three eyes at a relatively late stage (6-19 months postoperatively): reoperation was successful in two cases. With regard to functional results, six eyes had a visual acuity of between 1/25 and 0.6, and in four it was in the range between perception of light projection and hand movements. There were three cases with keratopathy encouraged by aniridia or hypotonia. One eye with emulsification of the silicone oil developed a secondary glaucoma which responded to topical treatment. In three cases the silicone oil was removed without complications. In one eye there was an expulsive choroidal hemorrhage which could not be managed intraoperatively and which led to phthisis and amaurosis postoperatively.

Adolescent↗
PubMed1988

[Role of macrophages and fibronectin in vitreoretinal proliferation].

Proliferative vitreoretinopathy (PVR) is characterized by the periretinal proliferation of nonneoplastic cells complicated by traction retinal detachment. In this study, we report the demonstration of macrophages, which are thought to be involved in the etiology of this intraocular disease, in human periretinal membranes by an immunochemical staining procedure using a monoclonal anti-human macrophage antibody. Fibronectin, a high-molecular protein of plasma and extracellular matrix, may be visualized accordingly and could act concomitantly with macrophages as an important factor in PVR. Fibronectin is shown to be present in high quantities (Elisa) in vitreous aspirates from patients with PVR. We hypothesize that the interaction of macrophages and fibronectin may be a crucial step in the development of PVR.

Cell Division↗
PubMed1987

Intraocular daunorubicin for the treatment and prophylaxis of traumatic proliferative vitreoretinopathy.

Daunorubicin has been used in the treatment of advanced cases of human posttraumatic proliferative vitreoretinopathy. To reduce the failure rate of trauma surgery from proliferative vitreoretinopathy recent efforts have been directed toward the pharmacologic inhibition of cellular reproliferation. We administered intravitreal daunorubicin to 15 patients after vitrectomy and before silicone oil or gas injection. A solution containing 7.5 micrograms/ml of daunorubicin was infused over a ten-minute period. Anatomic success was obtained in 14 patients, and one patient had a renewed traction retinal detachment. Visual acuity improved in all patients postoperatively. We found no toxic effects to the optic nerve, the retina, the lens, or the cornea.

Daunorubicin↗
PubMed1987

Cytotoxic effects of daunomycin on retinal pigment epithelium in vitro.

Proliferative vitreoretinopathy (PVR), the most severe complication of retinal detachment surgery and posterior segment ocular trauma, is characterized by the intraocular proliferation of non-neoplastic cells with formation of vitreal and periretinal membranes resulting in renewed traction retinal detachment. As retinal pigment epithelial (RPE) cells have been shown to play an essential role in the development of PVR, we investigated the acute and chronic effects of daunomycin on the morphology and viability of porcine RPE cells in vitro. The intense and complete inhibition of cell proliferation reported in this study adds to previous evidence that daunomycin may be useful for pharmacological treatment of human PVR.

Animals↗
PubMed1987

Keratopathy following pars plana vitrectomy with silicone oil filling.

Out of 196 aphakic and 4 phakic eyes with silicone oil in the anterior chamber (all vitrectomized, postoperative follow-up 6 months to 5 years) we found 83 eyes (42%) with keratopathy. They present clinically and histologically as calcific band keratopathy (55 eyes) or diffuse bullous corneal edema (28 eyes). Time of onset, course and frequency in correlation to preoperative diagnosis are analyzed. Pathogenesis, prevention and therapy of keratopathy are discussed.

Cicatrix↗
PubMed1986

Histopathological findings in eyes after silicone oil injection.

Eight eyes were examined histologically after silicone oil injection. Intraretinal deposits suggestive of silicone were not present in attached retinas, but were frequently observed in detached retinas when subretinal silicone occurred. This may possibly be due to defects in the horizontal conducting structures of the retina such as those occurring in persistent detachment with disorganization of the retina. Morphologically, the retina was essentially normal 3.5 years after the silicone injection. This observation contradicts the idea that silicone oil has a toxic effect.

Eye↗
PubMed1986

[Perforating eye injuries with multiple intraocular foreign bodies following military maneuver accidents].

Nine patients sustained massive ocular injuries mostly bilateral, caused by practice ammunition fragments during military maneuvers. The injuries consisted of severe contusion and perforation damage to the cornea, traumatic cataract, vitreous hemorrhage, and multiple small intraocular foreign bodies frequently impacting on or penetrating the retina. Extraction of the foreign bodies was difficult, usually because they could not be localized preoperatively, because of optical problems due to corneal opacifications and frequent hemorrhages, and because of a lack of posterior vitreous detachment. Nevertheless, in the 15 eyes which underwent secondary surgery travel vision (1/35 to 0.2) was achieved in three and good visual acuity (0.3 to 1.0) in eight. Only four eyes ended up with practical blindness (LP to hand movements) due to retinal traction detachments with proliferative vitreoretinopathy.

Blast Injuries↗
PubMed1986

[Proliferative vitreoretinopathy. Pathogenesis and possibilities for treatment with cytostatic drugs].

The pathogenesis of proliferative vitreoretinopathy (PVR) is divided into five stages: (1) destruction of the integrity of vitreoretinal structures; (2) cell migration; (3) cell proliferation; (4) cell contraction, and (5) stabilization by synthesis of the extracellular matrix. Current knowledge concerning the treatment of PVR with antiproliferative drugs (5-fluorouracil, Daunomycin) is described.

Antineoplastic Agents↗
PubMed1986

[Late complications following silicone injection. Long-term follow-up of 100 cases].

The authors report on late complications in 100 eyes in which silicone oil injection had been used to treat complicated retinal detachment; the follow-up-period was two years. Redetachment developed in 28 of 100 eyes (30%) during the first year, cataract in 43 of 54 phakic eyes, and glaucoma in 22 of 100 eyes (= 22%). Keratopathy developed in 29 of 46 aphakic eyes up to the 18th postoperative month. After treatment of these complications a visual acuity of 1/50 to 0.4 was observed in 50 percent of the eyes two years after the operation.

Corneal Diseases↗