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Biomedical subjects

K Heim

Publications and source records attributed to K Heim.

70 records · Page 4Linked to original sources
PubMed1987

The relation between saliva estriol levels in pregnancy and infant birth weight.

Specimens of saliva were obtained from 106 women with normal pregnancies and from 42 women, whose children turned out to small for dates (birthweight below the 10th centile). Saliva estriol was highly significantly (P less than 0.0001) decreased in the group with a newborn with a birthweight below the 10th centile (500 +/- 340 ng/ml, mean +/- SD) when compared with the group with infants whose birthweight was over the 10th centile (813 +/- 449 ng/ml). Estriol determination in saliva seems to be a simple, non invasive method of aiding the detection of fetal growth retardation.

Estriol↗
PubMed1986

[Prevention of pulmonary embolism using a vena cava filter and cava clip].

Surgical prophylaxis of pulmonary embolism by implantation of Vena-cava-filter (Greenfield) or Vena cava clip (Adams de Weese) was performed in 24 patients. The following indications were used: Recurrent pulmonary embolism under adequate anticoagulation, Pulmonary embolism in cases of contraindications to anticoagulation, Floating thrombus occurring late following deep vein thrombosis, After pulmonary embolectomy. In a retrospective study we recognized 0% recurrent pulmonary embolism, a vena cava occlusion rate of 4% and no clinically relevant signs of bilateral venous stasis in the lower limbs.

Adolescent↗
PubMed1986

[Breast sonography with high-frequency short-focusing transducers].

Since 1984 two high-frequency short-focussed linear transducers have been used for breast sonography at Innsbruck University Gynaecological Clinic. In the study reported here 121 patients with pathologic change in the breast were examined. A significant improvement in diagnosis was achieved: on the one hand because of the improved resolution and distinction of the lesions, and on the other because of the manageability of the transducers and the individually adjustable breast compression. Both perforation of the physiological mammary strata as well as clearly distinguishable tumor ends without echoproof halos were considered reliable indicators of the malignancy of the respective changes.

Abscess↗
PubMed1976

[Cineradiographical studies of local ventricular motility before and after aorto-coronary bypass (author's transl)].

The purpose of this study was to observe the effect of surgical revascularization on the motility of the left ventricular segment distal to a high grade coronary stenosis. In 17 patients with LAD bypass local relative segment shortening lambda (lambda = diastolic length - systolic length/diastolic length X 100) was determined measuring the distances of coronary bifurcations and surgically implanted myocardial metal markers frame by frame in high speed cineradiography. A group of 14 patients whose angina pectoris was abolished after operation and where bypass proved to be patent showed significant increase of lambda within the first postoperative days (lambda preop. = 3,4 +/- 18,3 SD, lambda postop. = 18,9 +/- 8,0 SD, p less than 0.05). Paradoxical movement had disappeared in 4 cases. In the following two-monthly controls up to one year no significant further alterations of local motility were seen. Three patients with persisting angina did not show any increase of segment shortening. It is concluded that aorto-coronary bypass surgery can restore impaired local motility in the majority of patients. The method described is useful for repeated non-invasive controls of the success of operation.

Angina Pectoris↗
PubMed1976

[X-ray cinematographic studies of local ventricular dynamics after aortocoronary bypass].

In 12 patients with high-grade coronary stenosis local motility before and after aortocoronary vein bypass was estimated by cineradiography of coronary bifurcations and surgically implanted myocardial metal markers. A group of patients with relief of angina showed significant increase of local segment shortening within the first postoperative days. During the following months no further alteration occurred. In three patients with persisting angina no improvement of local motility could be found.

Cineradiography↗
PubMedDate not supplied

[Heart-specific L-myosin in pregnancy and tocolysis therapy].

Determination of light-chain (L-)myosin represents the currently most sensitive and specific method for detection of myocardial damage, which often was reported during tocolysis with betamimetics. Compared with 51 healthy pregnant subjects, it was not possible to demonstrate any pathologic increase in 14 patients, who underwent a tocolytic treatment with ritodrine-verapamil.

Adult↗
PubMedDate not supplied

Modulation of CA-125 release by inflammatory cytokines in human peritoneal mesothelial and ovarian cancer cells.

In the present study the modulatory effects of inflammatory cytokines, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), on CA-125 release in established ovarian cancer cell lines and in human peritoneal mesothelial cells (HPMC) both grown as monolayers, were investigated. The purity of mesothelial cell cultures were confirmed by the positivity of the cells for vimentin and cytokeratins 8 and 18, and their negativity for markers CD34 and CD68, thus excluding contamination by endothelial cells and macrophages. The preliminary results of CA-125 measurements in the culture medium clearly indicated differences in the pattern of CA-125 expression and release between normal and malignant cells under the influence of inflammatory cytokines. Furthermore, it seems that normal mesothelial cells play a crucial role as a source of CA-125 found in ascitic fluid or in pleural effusions and possibly even in the serum since secretion of this tumor marker into the culture medium was found to be significantly higher in HPMC than in ovarian cancer cells.

CA-125 Antigen↗