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K Hegedus

Publications and source records attributed to K Hegedus.

6 recordsLinked to original sources
PubMed2006

Production of proinflammatory cytokines by syncytiotrophoblasts infected with human cytomegalovirus isolates.

Forty per cent of women with primary cytomegalovirus (CMV) infection during gestation transmit the infection to their fetuses, which may result in abnormalities for the newborn, varying in degree from mild to severe. The factors whereby CMV in the placenta develops into a fulminating infection and spreads to the fetus are not known. In this study the production of proinflammatory cytokines was investigated in syncytiotrophoblast (ST) cultures infected with CMV strains. The interrelationships between the cytokines produced in the ST cultures and the number of nuclei of ST expressing the CMV immediate-early (IE) gene were examined. To resemble a natural infection, clinical CMV isolates and a low multiplicity of infection were used. TNF-alpha and IL-1 beta were not detected in the supernatants of any ST cultures. Similar or increased amounts of IL-6 were found in the CMV-infected cultures. The IL-8-inducing capacities of the CMV strains differed in the ST cultures. The IE gene expression of the virus provided was dependent on the amount of IL-8 produced in the STs. Our observations indicate that certain CMV strains induce high amounts of IL-8, which in turn enhances CMV replication in the placenta, while others can replicate if the IL-8 is provided by a co-infecting agent.

Cell Nucleus↗
PubMed2000

Oncology patients' and oncology nurses' perceptions of nurse caring behaviours.

Previous research on patients' and nurses' perceptions of nurse caring behaviours has documented significant differences in the ranking of important behaviours. However, these samples have included a variety of medical-surgical patients and nurses and different types of institutional settings, all of which may have affected the results. The present study sought to determine if patients and nurses from one subspecialty area and one institution would have more concordant perceptions of caring. Forty-four oncology patients and 49 oncology nurses completed the Respondents Perceptions of Caring Behaviour Scale (RPCBS). Results showed that overall mean patient rankings were highly correlated with mean nurse rankings (Spearman's correlations coefficient 0.94, P<0.0001). The Wilcoxon two-sample rank sum test was used to test the difference in rank of the 20 items between the patients and nurses. There was a significant difference in rank in only six of the 20 items. These data suggest that oncology patients and nurses have more concordant perceptions of caring than previously investigated groups. Implications for practice and further research are discussed.

Journal Article↗
PubMed1993

Advanced practice: a model for neonatal/perinatal and women/child nursing.

Collaboration between service and academia has often been disparate. A new model of cooperation was designed in the Fall of 1992 by faculty at the University of Connecticut School of Nursing and nurse administrators at John Dempsey Hospital of the University of Connecticut Health Center. A combined effort was undertaken to expeditiously prepare, at the graduate level, acute care nurse practitioners in Critical Care and Neonatal/Perinatal Nursing. The impetus for the collaborative effort was due in part to: reduced medical residency hours for patient coverage; limited access by patients to care in teaching hospitals because of demands in practice and academic roles; the need to bridge the gap between nursing and medicine; and fragmentation of care. The premise underlying all teaching, learning, and evaluation in the program is androgogy, or the art and science of helping adults learn. The program meets the current National Certification Corporation requirements for certification eligibility. A new evaluation instrument, the Learning Assessment Resource Scale (LARS) was designed by operationalizing Benner's seven domains of nursing practice. The Learning Assessment Resource Scale is based on the premise that expert nursing care is holistic rather than procedural. As an outcome of the collaboration between service and academe, there is enhanced mutual respect, the care-cure dichotomy has been bridged, and advanced practice nurses are educationally prepared to give expert care.

Certification↗
PubMedDate not supplied

Networking: a managerial strategy for research development in a service setting.

An innovative managerial strategy--networking--used to establish and promote a nursing research program within three teaching hospitals in Boston is outlined in this article. Networking provides an opportunity for research and program development experts to share resources to meet common needs and goals. One of the advantages of a research network is that it can provide educational offerings that will stimulate all levels of professional nursing staff independent of their research background. Results of a survey the network conducted to determine a citywide profile of nursing research needs are presented.

Boston↗