Search PubMed⌕ Search

Biomedical subjects

K Haze

Publications and source records attributed to K Haze.

At least 145 records · Page 8Linked to original sources
PubMed1984

[Factors influencing the development of low output state in patients with right ventricular infarction].

Right ventricular infarction is frequently accompanied by a low output state, but the factors influencing the development of this state remain unknown. To elucidate these factors, clinical findings, hemodynamic findings and left ventricular infarct size (T1-score) calculated from thallium-201 myocardial scintigrams by a circumferential profile method were evaluated in 147 consecutive patients with acute transmural inferior myocardial infarction. They were divided into two groups: 44 patients with right ventricular involvement (RVI group) and 103 patients without right ventricular involvement (IMI group). A low cardiac output state was defined when the cardiac index was less than 2.2 L/min/M2. There was a good correlation between T1-score and any of peak value of serum creatine phosphokinase (CPKmax), total released CPK (CPKr) and left ventricular ejection fraction (LVEF) (r = 0.66, 0.74 and -0.54, respectively), indicating the usefulness of T1-score as an index of left ventricular damage. Compared to the IMI group, the RVI group showed a higher average of age (p less than 0.01), lower systemic blood pressure (p less than 0.01), higher right atrial pressure (p less than 0.001) and lower cardiac index (p less than 0.01). Furthermore, the incidence of a low output state (RVI group : 47.7% vs IMI group : 14.6%, p less than 0.001) and mortality (25.0% vs 7.8%, p less than 0.01) were higher in the RVI group. However, CPKmax, CPKr, LVEF and T1-score, which were considered to reflect the severity of left ventricular damage, were not different between the two groups. T1-score was inversely correlated with cardiac index in the RVI group (r = -0.49, p less than 0.05), and with left ventricular stroke work index in the both groups (RVI group; r = -0.46, p less than 0.01, IMI group; r = -0.64, p less than 0.01). Additionally, age as well as heart rate was correlated significantly with cardiac index (r = -0.45, p less than 0.001 and r = 0.35, p less than 0.001, respectively), and the percentage of elderly patients (age greater than 60 years) and the incidence of bradycardia (heart rate less than 60/min) were both higher in the RVI group than the IMI group (either p less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)

Age Factors↗
PubMed1983

Significance of symptomatological diagnosis and treatment of angina pectoris developing into acute myocardial infarction.

Consecutive 200 patients with angina pectoris (AP) and 310 with acute myocardial infarction (AMI) were studied in order to elucidate the significance of symptoms and treatment of AP associated with AMI, and to evaluate the classification of unstable angina (UA) according to the American Heart Association (AHA). The AMI group consisted of 110 patients without preinfarction AP, 99 with UA and 101 with AP who did not meet the criteria of UA and were designated as non-UA (NUA) in this study, while the AP group consisted of 65 with UA and 135 with NUA. Among 19 patients who developed AMI during their hospitalization, 12 were UNA. Patients with NUA of both groups revealed various modes of anginal attacks. Eighteen patients of the AMI group and 29 of the AP group were considered to be clinically stable and the others were unstable. Treatment of the AP group resulted in an improvement of AP in 191 patients, while in the AMI group AP was not treated in 93 and improved in 23. The participation of fixed stenosis and/or spasm of coronary arteries was examined in the AP group. There was no difference in the participation of these factors as a causative mechanism for anginal attack between UA and NUA. In conclusion, it is not pertinent to dispute that UA of the AHA is the only high risk AP for developing AMI, but for the prevention of AMI it is important to treat AP by the precise evaluation of its symptoms and by the determination of the participation of fixed stenosis or spasm of coronary arteries in each case.

Adult↗
PubMed1983

Clinical problems in the management of patients with acute myocardial infarction from its onset to the patients' return to work.

Out of 330 patients with acute myocardial infarction (AMI) admitted to our institution, 256 patients entered our 3-week rehabilitation program and discharged from the hospital. Through the execution of the program, its feasibility and safety were examined, and guidelines for the progress of the program were re-evaluated. The state of outpatient community life and its determining factors were also investigated by a questionnaire. The following results were obtained: 1) Over 90% of patients with uncomplicated MI could complete the rehabilitation nearly on schedule, indicating the feasibility of the program. 2) Mortality after ambulation and serious complications related to rehabilitative activities were very few, indicating the safety of our rehabilitation program. 3) Among guidelines for the progression of the program generally accepted, the case for an elevation of blood pressure as well as an ST depression was found to be especially important in order to prevent serious complications. 4) Age, discharge exercise capacity, left ventricular function and the severity of coronary disease were important factors influencing the patients' returning to work.

Activities of Daily Living↗
PubMed1983

Efficacy of isosorbide dinitrate tape on exercise tolerance of patients with angina pectoris.

Evaluation was made on the efficacy of isosorbide dinitrate tape (ISDN tape, TY-0081, Frandol Tape), a preparation newly developed in Japan, regarding the relationship between the exercise tolerance in patients with stable effort angina pectoris and plasma concentrations of ISDN. Placebo(s) or one to three pieces of isosorbide dinitrate tape (10 cm x 10 cm in size, containing 40 mg/tape) were applied to the patients and ISDN plasma concentrations were measured every 6th(15:00) and 24th (9:00) h after each application (9:00). Treadmill tests were repeated for the measurement of exercise tolerance according to a prescribed protocol where the exercise endpoint was the occurrence of chest pain. Correlation was found between the number of ISDN tape applied and the plasma concentrations, as well as between the isosorbide dinitrate plasma concentration and treadmill exercise time in 7 cases out of 10. Exercise time was increased significantly by the application of one piece of ISDN tape or two to three pieces of the tape, compared to the control or placebo study, respectively. The duration of actions lasted more than 24 h. These results suggest the efficacy of ISDN tape on angina pectoris, especially in its durability of action which lasts over 24 h.

Aged↗