[Case of pulmonary tuberculosis with the development of ileal perforation during chemotherapy].
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
K Hatake
Publications and source records attributed to K Hatake.
[Statistical studies on suicides inspected by the Hyogo Medical Examiner's Office during the years from 1971 to 1980].
Explore the source record for details and available documents.
Adolescent↗
A case of acute myelogenous leukemia with advanced atrioventricular block and pericardial effusion caused by leukemic cell infiltration.
A 40 year-old woman with acute myelogenous leukemia developed an advanced atrioventricular block and pericardial effusion. On autopsy, pericardial effusion without pericarditis and mononuclear cell infiltration in His bundle were found. Focal infiltration of His bundle by leukemic cells was suggested as the cause of the atrioventricular block.
Adult↗
Concomitant association of pyroglobulinemia and cryoglobulinemia in 2 patients in multiple myeloma.
We have reported two cases of multiple myeloma associated concomitantly with pyroglobulinemia and cryoglobulinemia. One of them showed blood picture of plasma cell leukemia. Plasma cell leukemia with two abnormal serum proteins at the same time, has not been reported yet to our knowledge. In that case, the large amounts of plasma cells were detected in the urine sediment.
Bone Marrow↗
Autologous stem cell transplantations for recurrent adult T cell leukaemia/lymphoma using highly purified CD34+ cells derived from cryopreserved peripheral blood stem cells.
We performed double autologous PBSCT in one fulminantly relapsed ATL patient. Cryopreserved PBSCs containing tumour cells were thawed, and CD34+ cells were selected for by immunomagnetic beads, with the aim of decreasing the number of re-infused tumour cells. The patient received 0.72x10(6) and 0.90x10(6) CD34+ cells/kg. The graft contained less than 0.1% T cells. The patient had a very good recovery, and maintained a good quality of life, until she died on Day 339 after her first PBSCT in third relapse. We conclude that autologous PBSCT for ATL patient has benefit in some instances, and cryopreserved PBSCs can be used for CD34+ selection.
Adult↗
Elevated serum levels of macrophage colony-stimulating factor in patients with Kawasaki disease complicated by cardiac lesions.
OBJECTIVE: The main pathogenic characteristic of Kawasaki disease (KD) is the activation of mononuclear phagocytes. The cytokines produced by activated monocytes/macrophages elicit proinflammatory and prothrombotic responses in endothelial cells. Thus, we speculated that macrophage colony-stimulating factor (M-CSF), derived from monocytes/macrophages or vascular endothelial cells, might play an important role in the pathogenesis of the acute phase of KD. The aim of this study was to investigate the possible role of M-CSF in the pathogenesis of KD and to elucidate the relationship between serum M-CSF levels and clinical features and cardiac lesions. METHODS: Using ELISA, we serially assayed M-CSF and several cytokines, including interleukin-6, interleukin-8, tumor necrosis factor-alpha and interferon-gamma in the sera of 32 KD patients aged 2 months to 4 years. RESULTS: The serum M-CSF level during the first week of illness was significantly higher than during the second week or thereafter (first week, median 1710.0; second week, 1121.0; third week, 867.3; fourth week, 909.4 U/ml, p<0.001) in our KD patients. Serum M-CSF levels during the first week of illness were also higher in patients with mitral and/or aortic valvular insufficiency than in patients without cardiac complications. Furthermore, serum M-CSF levels in patients with persistent coronary dilatation were higher than in those with no cardiac complications. CONCLUSION: M-CSF plays a critical role in the pathogenesis of KD and can be used as an indicator for the risks of valvulitis and coronary arteritis.
Aortic Valve Insufficiency↗