Search PubMed⌕ Search

Biomedical subjects

K Hata

Publications and source records attributed to K Hata.

At least 415 records · Page 23Linked to original sources
PubMed1986

Radiation therapy for primary non-Hodgkin's lymphoma of the head and neck in stage I-II.

From September 1977 through January 1983, 34 previously untreated cases with primary non-Hodgkin's lymphoma of the head and neck in stage I-II were treated at our department. 16 cases were classified into stage I and 18 into stage II. Patients were treated with 4 MV X-ray (40 to 45 Gy) which encompassed Waldyer's ring and supraclavicular region with or without chemotherapy. The survival rates at three years were 93% and 50% in stage I and II, respectively. Stage, surface markers (T- and B-cell analysis) and initial primary site and the level of lymph node involvement were important prognostic factors. Chemotherapy in pre- or post-irradiation was essential, especially for cases in stage II. It was also indicated that the adequacy of radiation portal with special reference to anatomical consideration was necessary.

Combined Modality Therapy↗
PubMed1986

[Radiation therapy of malignancies of the digestive organs].

Malignancies of digestive organs have been treated, as a first choice, by surgery, and conventional fractionated radiotherapy has been palliatively applied to those inoperable or recurrent cases. IOR and intracavitary radiotherapy, which made it possible to give large dose of well localized irradiation to the lesions, are now available in combination with surgery or on its own. Here mentioned the IOR of pancreas, biliary tract, stomach and rectum, and also discussed the intracavitary radiotherapy of esophagus and biliary tract.

Brachytherapy↗
PubMed1986

Hyperphosphatemia after surgical correction of hypercortisolism in patients with Cushing's syndrome.

The change in phosphate metabolism after surgical correction of Cushing's syndrome was examined in 3 consecutive patients. During replacement therapy with hydrocortisone after successful operation, when serum cortisol levels were undetectable in the early morning, serum inorganic phosphate (PI) levels increased gradually with reduction of the replacement dose of hydrocortisone. Hyperphosphatemia developed 3-7 weeks after surgery when the patients was given 20-25 mg/day of hydrocortisone, and 2 patients demonstrated clinical manifestation of glucocorticoid deficiency. During these periods, there was a significant inverse relationship between serum Pi and the replacement dose of hydrocortisone in each patient. Thereafter, serum Pi started to decrease despite administration of the same amount of hydrocortisone and became normal by 26 weeks after surgery. Daily urinary Pi excretion was decreased compared to that before surgery, and the maximal tubular reabsorptive capacity for Pi (TmP/GFR) changed in parallel with serum Pi in all patients. Serum immunoreactive parathyroid hormone and urinary 3',5'-cyclic adenosine monophosphate excretion remained unchanged during the postoperative course. The serum concentrations of 1,25-dihydroxyvitamin D decreased from preoperatively normal values to subnormal levels after surgery with development of hyperphosphatemia and returned to normal with the fall of serum Pi. In summary, the present study demonstrates that surgical correction of hypercortisolism is accompanied by a transient hyperphosphatemia during the postoperative periods, probably due to increased renal Pi reabsorption, and that parameters of parathyroid function do not change during these periods. These results suggest that glucocorticoid has a direct action on Pi metabolism and that during the replacement therapy after surgical treatment of hypercortisolism hyperphosphatemia may develop due to relative glucocorticoid deficiency.

Cushing Syndrome↗
PubMed1985

Ultrasonographic identification and measurement of the human fetal adrenal gland in utero.

Ultrasonographic studies on the fetal adrenal gland were performed in utero on 100 fetuses 22-42 weeks of gestation. The correlations of the area of fetal adrenal gland (FAGA) with gestational age (r = 0.95, P less than 0.001) were high. The circumference of the fetal adrenal gland (FAGC) correlated well with the gestational age (r = 0.86, P less than 0.001) as did the length of this gland (FAGL) (r = 0.70, P less than 0.001). Ultrasonographic identification and measurement of the fetal adrenal gland in utero is thus an useful indicator to assess the growth and maturation of the fetal adrenal gland, and for detecting of congenital adrenal hyperplasia and hypoplasia.

Adrenal Glands↗
PubMed1985

Calcium metabolism in paravertebral ligamentous ossification.

Twenty-eight patients with paravertebral ligamentous ossification (PVLO) and 11 control subjects were studied in an attempt to examine possible involvement of disturbances in mineral metabolism in the development of PVLO. No significant difference in baseline serum calcium and fasting urinary calcium excretion was found between patients with PVLO and controls. Patients with PVLO showed lower serum inorganic phosphate (Pi) and tubular reabsorptive capacity for Pi (TmP/GFR) than controls. Basal nephrogenous cyclic 3',5'-AMP (NcAMP) was elevated in some patients with PVLO. A significant inverse relationship was found between basal TmP/GFR and NcAMP in patients with PVLO (r = -0.50; P less than 0.01). Compared with controls, patients with PVLO had significantly lower calciuric responses to an oral calcium load (P less than 0.05), suggesting decreased intestinal calcium absorption. Furthermore, a significant inverse correlation was found between basal NcAMP and the calciuric response in patients with PVLO (r = -0.42; P less than 0.05). Serum 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were not significantly different between the two groups. The size of ossified areas in paravertebral ligaments estimated from spinal radiograms inversely correlated with the calciuric response to the oral calcium load (r = -0.50; P less than 0.01). These data demonstrate that the development of PVLO is associated with decreased intestinal calcium absorption in the face of normal serum 1,25(OH)2D level. Thus, together with previous observations showing a high incidence of PVLO in patients with hypoparathyroidism or familial hypophosphataemic rickets/osteomalacia, the present results suggest that the defect in the action of 1,25(OH)2D may underlie the development of PVLO.

Calcifediol↗
PubMed1985

[Radiotherapy of pancreatic carcinoma].

During the 10-year period between 1974 and 1984, we treated 34 pancreatic carcinomas by radiotherapy as follows: Eight by intraoperative radiotherapy (IOR), five by external radiotherapy (ERT), and 21 by IOR in combination with ERT. The mean survival time of the eight patients treated by IOR was 5.6 months, and that of the 21 receiving the combination therapy 7.2 months. Although it is not statistically significant, patients treated by the combined regimen survived longer than those treated by IOR alone.

Aged↗
PubMed1985

[Radiation therapy for primary non-Hodgkin's lymphoma of the head and neck].

Thirty-seven previously untreated cases of primary non-Hodgkin's lymphoma in the head and neck were treated at our department from September 1977 through January 1983. The survival rate at three years by stage was 84% in stage I, 44% in stage II and 0% in stage III and IV. Stage, T- and B-cell markers, initial primary site, the level of lymph node involvement (UICC, 1978) and number were important prognostic factors. Chemotherapy in the pre- or post-radiation period was essential, especially in stage II. It was proved that adequacy of radiation portals with special reference to anatomical considerations was necessary.

Adolescent↗
PubMed1985

Rectal complication after remote afterloading intracavitary therapy for carcinoma of the uterine cervix.

From August 1978 through December 1980, 119 patients of previously untreated carcinoma of the uterine cervix were treated using RALS, remote afterloading high dose rate intracavitary therapy at our department. The data from 92 out of 119 patients were available for analysis of rectal complication. The incidence of major rectal complications was only 2% (2/92). Uni- and multivariate analyses were used based on the external criterion variable of rectal complication which included even minor injuries. By using these methods, it was clearly indicated that these factors such as TDF of rectum, Z-coordinate of weighted geometric center (WGC-Z), the dose of whole pelvic irradiation, history of chemotherapy and Treponema pallidum hemoagglutination test (TPHA) were important for occurrence of rectal complication. According to discriminant score, 71 out of 92 cases (77%) could be correctly discriminated.

Adult↗
PubMed1985

Immobilization and reproducibility in radiotherapy for cancer of the larynx and pharynx using simplified shell and bite-block.

In this paper we describe the comparative study concerning the immobilization during radiotherapy for cancer of the larynx and pharynx with or without shell and fixing device. Immobilization was continuously monitored by semi-conductor detector. Reproducibility was investigated by means of verification film. The result significantly indicated that better immobilization was obtained in the patients treated with use of the shell (p much less than 0.001). Reproducibility of the field arrangement was also sufficient throughout the course of radiotherapy.

Humans↗
PubMed1985

[Problems in the standardization of radiotherapy in cervical cancer].

In Japan there exists a interinstitutional difference in the response rate of cervical cancer, which is ascribed to the lack of intracavitary radiotherapy instruments. Provided the standardized treatment schedules are followed in all institutes, the over all responses will be definitely improved. Currently there are two major problems to be solved. Firstly, we have discussed IOR and hyperthermia to individualize locally advanced cervical cancers which are excluded from current standardized treatment method. Next we discussed indications for high dose rate intracavitary brachytherapy and the dose fractionation of it in relation to external beams.

Brachytherapy↗
PubMed1985

[Assessment of response to therapy based on the application of the guideline of reporting treatment results of head and neck cancer].

It seems difficult to compare the treatment results to each other, without "common language" to describe cancer therapy and its results. In this paper, guideline of reporting treatment results of head and neck cancer was applied to carcinoma of the pharynx and larynx. There were some problems in reporting of response, such as the measurability and assessment of the response. However, there were small discrepancies between assessment of response to therapy and end-point evaluation, i.e., long-term control, survival and disease-free survival, according to the prospective department-based and retrospective hospital-based studies.

Head and Neck Neoplasms↗
PubMed1984

[Radiation therapy of brain metastases].

Since January 1972, 87 patients with brain metastases were treated by radiotherapy. The lung was the most common site of the primary tumor (82%), breast was a distant second in frequency (9%). Patients were received hole brain irradiation using lateral opposing fields plus boost irradiation to involved area, if it was possible. The scheduled dose of irradiation was 51 Gy in 4 weeks, and 60 Gy in 6 weeks. About 80% of patient received symptomatic relief, and tumor regression in CT, 30% of them revealed complete regression. The median survival time was 8 months who received the dose more than 4 Gy, and the one year survival was 63%, in cases brain metastases were the only tumor site.

Brain Neoplasms↗
PubMed1984

[Investigation of rectal and bladder complications after RALS therapy for carcinoma of the uterine cervix].

From August 1978 through December, 1980, 119 patients with previously untreated carcinoma of the uterine cervix were treated using RALS, (remote-controlled) high dose rate intracavitary radiotherapy. The data from 92 out of the 119 cases were available for multivariate analysis for rectovesical complications. By using this method, it was clearly indicated that factors such as TDF of the rectum, weighted geometric center (WGC)-Z, the dose of whole pelvic irradiation, chemotherapy and TPHA were important in the occurrence of rectal complications. However, there was no definite physical or physiological factor to predict the occurrence of bladder complications.

Adult↗
PubMed1984

[Evaluation of the accuracy in radiotherapy for carcinomas of the hypopharynx and larynx].

Immobility and reproducibility were investigated to evaluate the accuracy in radiotherapy for carcinomas of the hypopharynx and larynx. Based on our comparative study using a semi-conductor detector, a light-cast shell is sufficient to maintain immobility during radiotherapy. In most cases, the range of reproducibility was within 5 mm throughout the course of radiotherapy.

Humans↗