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Biomedical subjects

K Harayama

Publications and source records attributed to K Harayama.

At least 19 recordsLinked to original sources
PubMed1990

Effects of feeding rats low protein diets containing casein or soy protein isolate supplemented with methionine or oligo-L-methionine.

The effects of supplementing 8% casein or 10% soy protein isolate (SPI) diets with graded levels of oligo-L-methionine (a mixture of hexa- and heptapeptides, OM) or L-methionine (Met) were studied in rats to determine the reason for the difference in nutritional quality between proteins and corresponding amino acid mixtures. As the OM concentration of the casein-based diet was increased from 0.02% to 0.6%, maximum weight gain was attained at 0.2%, and the growth-promoting activity of OM was comparable to Met at all the corresponding levels tested. Liver fat began to accumulate when supplemental Met reached a level of 0.08% of the casein diet, but OM addition did not produce a fatty liver at dietary levels of less than 0.3%. When SPI was used as the dietary protein source, the effect of supplemental OM was significantly less than that of Met. Digestibility of OM (assessed by incremental portal plasma Met concentration) was measured 30 min after feeding the casein or SPI diet supplemented with 3% OM using rats fasted for 24 h. Plasma Met concentration was greatly increased in rats fed the casein plus OM diet compared with that of rats fed the SPI + OM diet. Similarly, the 30-min portal Met concentration significantly increased in response to the casein + OM diet compared with the SPI + OM diet regardless of the prefed proteins (25% casein and 25% SPI for 2 wk).(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1982

Binocular visual function after surgery for detached retina.

Binocular visual function after surgery for detached retina was examined in 100 patients with a visual acuity of less than 0.3 in the reattached retina and with a visual acuity of more than 1.0 in the non-detached retina: 1) There was no significant sex difference in binocular visual function. 2) There was no significant difference in binocular visual function according to postoperative interval. 3) Maintenance of postoperative binocular visual function was best in patients under 19 years of age, and grew worse with age. 4) In patients with a visual acuity of more than 0.1 in the reattached retina, simultaneous perception was good in 100%, and fusion in more than 80%. However, stereopsis was worse in most cases. 5) In patients with a visual acuity of less than 0.1 in the reattached retina, all aspects of binocular visual function were worse, except in those under 19 years of age. 6) There was no significant difference in binocular visual function between patients with and without temporary amputation of extrinsic ocular muscles at operation. 7) There was no significant difference in binocular visual function between patients with and without macular detachment before operation. 8) In the patients who had had an encircling operation, binocular visual function was worse than in those operated on with other procedures, because the former had the severest retinal detachment.

Adolescent↗
PubMed1981

Prognosis of visual acuity after surgery for detached retina, with special reference to the unaffected eye.

In 600 patients with successfully operated unilateral retinal detachment, the visual acuity prognosis of the operated eye was studied in relation to that of the normal eye. Within 2 years after operation, most of these patients were in the following three groups: (1) visual acuity worse than 0.5 in the non-detached retina and worse than 0.1 in the reattached one; (2) visual acuity better than 1.0 in the non-detached retina and worse than 0.3 in the reattached one; and (3) visual acuity better than 1.0 in the non-detached retina and better than 0.8 in the reattached one. Some of the patients in group 2 showed greater improvement of the visual acuity in the reattached retina, which occasionally became superior to that in the non-detached one. In spite of possible improvement until 2 years after operation, the visual acuity in the reattached retina was apt to decrease after more than 5 years following operation. The presence of macular detachment was ill for the recovery of visual acuity. About 30% of the patients with a visual acuity of about 1.0 in the non-detached retina showed no improvement of the visual acuity in the reattached retina. About 50% of the patients with successful surgery for retinal detachment had a difference of more than 0.6 in visual acuity between the non-detached and the detached retinas.

Adult↗
PubMed1980

Development of the cornea during fetal life: comparison of corneal and bulbar diameter.

Two hundred twenty undamaged human fetuses without external malformations were supplied by the human embryo and fetus collection at the Department of Anatomy, Kyoto University. The diameters of the cornea and eyeball were measured by slide calipers under a stereomicroscope. The various diameters of the eyeball showed a parallel, linear increase from the 12th to the 28th week of menstrual age. Corneal diameters appeared to increase in parallel with the eyeball as a whole until the 16th week of menstrual age; later on their rate of growth declined. The corneal limbus could be recognized macroscopically at the 17th week of menstrual age and was distinctly seen from the 20th week of menstrual age. The corneal curve at the limbus began to be a little convex at the 21st week of menstrual age and became distinctly convex from the 23rd week. The cornea was transparent from the 12th to the 28th week of menstrual age. The sclera lost its transparency from the 21st week. It is significant that during fetal life the sagittal diameter of the eyeball is shorter than the vertical and transverse diameters.

Cornea↗
PubMed1979

Massive periretinal proliferation in retinal detachment in relation to diabetes mellitus.

The relationship between the 'diabetic state' and massive periretinal proliferation (MPP) in idiopathic retinal detachment was examined. In 18 (3.5%) of 508 cases of idiopathic retinal detachment, MPP occurred before or after retinal detachment surgery. In 24 cases of retinal detachment, a diabetic or suspected diabetic state was found. 11 of the 24 were receiving treatment for diabetes and never developed MPP, while 5 of the 13 patients who were not being treated had MPP. This suggests that MPP in retinal detachment may easily be induced by the diabetic state and prevented by treatment for diabetes. Additional causes of MPP in retinal detachment were giant tears, massive vitreous hemorrhages at operation and frequent recurrence.

Diabetes Complications↗
PubMed1978

Long-term results of retinal detachment surgery.

Patients treated successfully with retinal detachment surgery 11-39 years earlier were called back and examined. The average age was 35 years at the time of surgery and the average interval between the operation and this follow-up examination was 16 years. The visual acuity had decreased in many patients. The most frequent causes of this fall in visual acuity after surgery were cataract and macular degeneration. Chorioretinal atrophy with blackish pigment spots developed in the reattached retina a long time after surgery and caused defects in the visual fields. This atrophy seems to be related to the long duration of retinal detachment before and after operation, which may cause malnutrition of the detached retina and result in incomplete recovery of visual cells, leading to chorioretinal atrophy. Macular degeneration was caused or accelerated by detachment of the macula. There was no difference in postoperative ocular findings between only diathermy and combination of diathermy with segmental scleral-buckling procedures. However, Arruga's ring suture method induced cataract more frequently than did other surgical procedures.

Adolescent↗