Radioaerosol inhalation lung scintigraphy is discussed and its interpretation based on the segmental anatomy of the lung is presented. Correlation between bronchography and inhalation scintigraphy in 26 cases of bronchogenic carcinoma showed that partial obstruction of a major bronchus produces a clear "hot spot" with peripheral decrease of aerosol deposition, while partial or complete obstruction of the segmental bronchi causes segmentally decreased deposition distal to the site of obstruction. Even at an early stage, bronchogenic carcinoma may be detected by aerosol inhalation scintigraphy whenever the tumors are large enough to produce visible abnormalities of aerosol deposition.

Adult↗

PubMed1976

Lung scintigraphy with 51Cr-erythrocytes in Goodpasture's syndrome: case report.

A lung scan using 51Cr-labeled erythrocytes in a patient with Goodpasture's syndrome revealed radioactivity in the lung due to massive intrapulmonary hemorrhage.

Adult↗

PubMed1975

Tumor imaging after administration of 99mTc-labeled bleomycin.

Bleomycin, an anticancer drug, was labeled with 99mTc using stannous chloride and ascorbic acid and specific activities of 1-3 mCi/mg-eq with labeling efficiencies of 50-75% were achieved. Very rapid excretion of 99mTc-bleomycin through the kidney and concomitant rapid decrease of radioactivity in blood, various tissues and organs, and whole body were observed after intravenous administration of the radiopharmaceutical into tumor-bearing mice. In such animals, approximately 1% of the label was found in a transplanted fibrosarcoma within 30 min while 0.58% was recovered in such lesions even after 24 hr. In patients positive tumor images were obtained by scintigraphy as early as 1 hr after intravenous administration of 3-5 mCi of 99mTc-bleomycin. A total of 142 cases were examined by scintigraphy after administration of 99mIc-bleomycin and/or 67Ga-citrate. In 93 cases with various malignant tumors, tumor was detected in 80% using 99mTc-bleomycin and in 63% using 67Ga-citrate. Technetium-99m-bleomycin scintigraphy successfully detected tumors of the thyroid, lung, face, breast, extremity, and digestive tract and was also useful in finding metastatic lesions and brain tumors. However, 67Ga scintigraphy gave superior results in detecting lesions in patients with malignant lymphomas. In patients with inflammatory diseases, accumulation in lesions was detected in 13% using 99mTc-bleomycin and in 48% using 67Ga-citrate. The further use of 99mTc-bleomycin scintigraphy for tumor detection in patients appears to be warranted.

Abdominal Neoplasms↗

PubMed1974