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Biomedical subjects

K HABEL

Publications and source records attributed to K HABEL.

At least 19 recordsLinked to original sources
PubMed1964

POLYOMA VIRUS GENETIC MATERIAL IN A VIRUS-FREE POLYOMA-INDUCED TUMOR.

The DNA-agar technique for homology studies was used to investigate of the viral genetic material. Complemetary found between the polyoma DNA and the DNA of several mammalian species. The increased complementarity of the polyoma DNA to the DNA of polyoma-induced tumor reflects an increased frequency of common poly-nucleotide sequences in the tumor DNA.

Animals↗
PubMed1963

Interferon production by mouse leukocytes in vitro and in vivo.

Vaccinia virus penetrates, or is phagocytosed by, mouse leukocytes in vitro. A cytotoxic effect is observed, but no new infectious virus is produced. Vaccinia virus, as infectious particles, is eliminated from a culture of leukocytes at a more rapid rate than can be accounted for by thermal inactivation. Leukocytes infected with vaccinia virus produce a substance with the properties of interferon. The evidence presented suggests that leukocytes also produce interferon in vivo and that this interferon is related to the observed protective effect on the outcome of intracerebral vesicular stomatitis virus challenge in mice. It is postulated that leukocytes, in this manner, may make a positive contribution to the host's defense mechanism and to the process of recovery from viral infections.

Animals↗
PubMed1962

The role of interferon in vaccinia virus infection of mouse embryo tissue culture.

The production of an interferon-like substance by vaccinia virus is described. The physical properties of vaccinia interferon are shown to be similar to those of previously reported interferons. Data defining the role of vaccinia interferon in cell resistance and in establishment and maintenance of a carrier culture are presented. Elimination of virus from an infected culture is demonstrated and the role of interferon in the recovery process is considered.

Interferons↗
PubMed1962

Immunological determinants of polyoma virus oncogenesis.

Adult mice and hamsters can be made resistant to an isologous transplantable polyoma tumor by an inapparent infection with polyoma virus. This resistance is cell-mediated and seems not to be related to anti-viral serum antibodies. The basis of the resistance appears to be a transplantation type of cellular immunity directed against a "foreign" antigen contained in the tumor cell. Evidence has been presented to demonstrate this tumor antigen. It is possible that this phenomenon may explain the lack of oncogenesis by polyoma virus infection of adult mice, and the rarity of naturally occurring polyoma tumors.

Animals↗
PubMed1961

Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non-exposed persons. 3.

This study is the third in a series on virus-neutralizing antibody response to different schedules of antirabies serum and vaccines in previously non-exposed persons. Three types of vaccine were studied-phenolized (Semple), duck embryo and high-egg-passage (HEP) chicken embryo. Reduced schedules of vaccine, consisting of 2-7 inoculations given at various intervals, did not give results comparable in efficacy (time of appearance, level and persistence of antibody) with schedules comprising at least 14 daily inoculations of vaccine as determined in previous trials. The effectiveness of a booster dose in previously sensitized individuals was confirmed with a demonstration that a rise in serum antibody appears between 4 and 8 days after the booster inoculation. Effective sensitization appears to be as much a function of spacing of inoculations as of total dosage of vaccine antigen. Interference by immune serum with the antigenicity of subsequently administered vaccine, noted previously by the present authors and by other workers, was again confirmed. This interference could be overcome by the administration of a sufficient amount of vaccine.

Antibodies, Neutralizing↗