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Biomedical subjects

K H Wiese

Publications and source records attributed to K H Wiese.

7 recordsLinked to original sources
PubMed1999

Complete response of a gastric primary after a short but toxic course of 'S-1' EORTC Early Clinical Studies Group.

We report the case of an unresected, metastatic gastric cancer, which was treated with a very short course of the oral 5-fluorouracil (5-FU) prodrug S-1. The patient had to discontinue chemotherapy during the first treatment cycle due to severe toxicity, but achieved a pathologically confirmed, long-term complete response of her primary tumour, a diffuse-type poorly differentiated adenocarcinoma.

Adenocarcinoma↗
PubMed1984

[Comparative study of the effect of the calcium antagonist nifedipine, the beta receptor blockers acebutolol and propranolol and their combination on electrophysiologic parameters in the human].

It is well known that in the isolated atrium, nifedipine, verapamil and diltiazem slow down the spontaneous frequency and conduction velocity in the sinus- and in the atrioventricular node. Using therapeutic doses in man, we studied the influence of the calcium-antagonist nifedipine, the beta-blockers acebutolol and propranolol and a combination of these on sinus-node parameters (spontaneous cycle length AA, sinus-node recovery time SNRT, corrected sinus-node recovery time CSNRT, sinoatrial conduction time SACT), and on the intracardiac conduction time (PA-, AH-, HV-interval). Both beta-blockers slowed the spontaneous frequency of depolarization of the sinus-node, but lengthened sinus-node recovery time and sinoatrial conduction time (acebutolol: AA + 6% n.s.; SNRT +5% n.s.; CSNRT +2% n.s.; SACT +33% s.; propranolol: AA +9% n.s.; SNRT +15% s.; CSNRT +37% n.s.; SACT +32% n.s.). Simultaneously PA-, AH and HV-interval lengthened (acebutolol: PA +16% n.s.; AH +7% s.; HV +15% s.; propranolol: PA +19% n.s.; AH +16% s.; HV +9% s.). Nifedipine caused essentially no change in sinus-node parameters nor in intracardiac conduction time in man (AA -11% s.; SNRT -12% s.; CSNRT -7% n.s.; SACT +35% n.s.; PA +4% n.s., AH -2% n.s.; HV +5% n.s.). This is in contrast to results obtained in the isolated atrium, and is different from other calcium-antagonists such as verapamil, gallopamil and diltiazem. The effect of acebutololinduced beta-blockade is not intensified by nifedipine (AA -3% n.s.; SNRT -6% s.; CSNRT -12% s.; SACT -19% n.s.; PA -5% n.s.; AH +3% n.s.; HV +9% n.s.).

Acebutolol↗
PubMed1982

[Prinzmetal phenomenon and a rare coronary anomaly as infarct and death cause of a 45-year-old patient].

We report about the sudden death of a 45-year-old woman with anomalous origin of both coronary arteries from a single ostium in the right sinus of Valsalva, the left coronary artery running between the aorta and the pulmonary trunk. The clinical picture was that of Prinzmetal's form of variant angina, and it preceded death of inferior myocardial infarction. Coronary spasm and the anatomical anomaly were demonstrated by coronary angiography. There was no atheromatous plaque or other obstructive lesion in the dominant right coronary artery which could have explained the inferior myocardial infarction seen at autopsy. This is the first detailed report in which this rare coronary anomaly has been associated with Prinzmetal's variant angina. The demonstration of spasm in the dominant coronary artery and of an infarct in that part of the myocardium supplied by it in the absence of any anatomical obstruction suggests that this patient's death resulted from coronary spasm.

Angina Pectoris, Variant↗
PubMed1981

[Type and frequency of cardiac arrhythmias dependent on age, therapeutic aspects (author's transl)].

Resting-, exercise and 24-h-ECG tracings of outpatients were examined for cardiac arrhythmias and were analyzed for age-dependent phenomena in the range between 20 and 100 years. Typical of higher age was especially the combination of different arrhythmias, in particular the simultaneous occurrence of slow and fast disturbances, which, of course, makes medical therapy difficult. Since ventricular arrhythmias, when classified according to Lown, have a better prognosis in the age group above 70 than between 40 and 70 years, antiarrhythmic drugs should be prescribed with extreme caution to older people and should be limited to exceptions which are detailed in this study.

Adult↗
PubMed1975

[Light and electron microscopic investigations on the chorionic plate of the human placenta at term (author's transl)].

The chorionic plate of the human placenta at term consists of amniotic epithelium, amniotic connective tissue, intermediate layer, chorionic connective tissue, cytotrophoblast, and syncytiotrophoblast. - The connective tissue layers are divided into unorientated (situated just below the amniotic epithelium and in direct contact with the trophoblast) and orientated layers (between the two unorientated connective tissue layers). Besides an accelular border below the amniotic epithelium the connective tissue includes fibrocytes, fibroblasts, histiocytes, and old Hofbauer cells in the intermediate layer. - From the edge of the chorionic plate to its centre, the number of well preserved cytotrophoblasts decreases; instead of them especially intercellular substances (subchorial fibrinoid) but also degenerating cells predominate. In the trophoblast layer rests of chorionic villi are localized. Among the intact cytotrophoblasts 4 types can be distinguished (less differentiated, well differentiated, spongiotrophoblast-like, and glycogen-rich cytotrophoblastic cells). They are interpreted as different developmental stages of one and the same cell population. - The syncytiotrophoblast is inter rupted at many places; only fragments can be observed. Then cytotrophoblastic cells or intercellular substances may form the border to the intervillous space.

Amnion↗