[Cholinergically influenced narcosis and brain acetylcholine content of the mouse].
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Acetylcholine↗
Biomedical subjects
K H Westermann
Publications and source records attributed to K H Westermann.
[Tremor and brain acetylcholine contents of infantile and senile rats after administration of arecoline].
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Acetylcholine↗
Effects of oxotremorine after nigrostriatal lesions in rats.
Bilateral injection of 6-hydroxy-dopamine (6-OH-DA) (8mug/4mul) into the substantia nigra causes a significant decrease of the dopamine content in the nucleus caudatus. The intraventricular application of 6-OH-DA (250 mug/10 mul) induces a considerable decrease of dopamine in the caudate nucleus as well as in the globus pallidus and in the medial septal region. Simultaneous changes in norepinephrine content are less spezific. It has to be assumed that there are dopaminergic nerve endings in the glubus pallidus not originating in the substantia nigra. Only after intraventricular applications of 6-OH-DA s short-term and reversible reduction of oxotremorin-induced tremor has been observed. Lesions of the nigrostriatal pathway cause an impairment of motility, probably elicited by rigidity and akinesia. These symptoms correlate better than the tremor to biochemical changes following nigro-striatal pathway lesions.
Animals↗
Influence of lesion of the median raphe nucleus on motility and dopamine turnover.
Both the spontaneous locomotor activity and the locomotor activity stimulated by apomorphine are enhanced in raphe lesioned animals. The exploratory activity does not show clearcut differences. After unilateral microinjection of dopamine into dopaminergic areas intensity of rotation and dominance of direction are amplified in lesioned animals. Other regions fail to evoke asymmetric or enhanced motoric reactions. The sensitivity of the dopaminergic system of raphe lesioned animals is increased too against unspecific stimulation, but with less strong dominance of direction. The general enhancement of motor activity reflects the inhibitory influence of the serotonergic system. In parallel to the change of behavior we observed a moderate increase of dopamine content connected with an accelerated turnover in lesioned animals.
Animals↗