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Biomedical subjects

K H Stenzel

Publications and source records attributed to K H Stenzel.

At least 217 records · Page 12Linked to original sources
PubMed1967

Collagen-derived membrane: corneal implantation.

Behavior of membranes derived from collagen was investigated in rabbit corneas. Disks of the membrane were placed between the lamellae of corneas which were then examined grossly, biomicroscopically, and histologically. The membranes remained clear, and almost no reaction or evidence of reabsorption was seen during an observation period of 6 months. These characteristics make the material potentially useful for heterotransplantation in the cornea.

Animals↗
PubMed1966

Biosynthesis of gamma globulin: studies in a cell-free system.

Incorporation of C(14)-amino acids into high-molecular-weight material precipitable by trichloroacetic acid indicates that microsomal cell-free systems, derived from spleens of immunized rabbits, are active in protein synthesis. Protein was made soluble by ultrasonic irradiation of the cell-free incubation mixtures, and low-molecular-weight materials were removed by dialysis and gel filtration. Chromatography and radio-immunoelectrophoresis of this soluble protein fraction reveal C(14)-labeled protein having several characteristics of gamma globulin.

Animals↗
PubMedDate not supplied

Hydroxyl radical scavengers inhibit human natural killer cell activity.

As natural killer (NK) cell activity is an essential constituent of host defence systems and reactive oxygen intermediates participate in such defence, the effect of scavengers of oxygen radicals on NK cell activity was investigated. Hydroxyl radical (OH) scavengers (dimethyl sulphoxide (DMSO), thiourea, dimethylurea, tetramethylurea, benzoic acid, ethanol, methanol and ethylene glycol) inhibited NK cell activity. Catalase, a scavenger of H2O2, and superoxide dismutase (SOD), a scavenger of O-2, either alone or in combination, did not inhibit NK cell activity. Inhibition of the lipoxygenase pathway of arachidonic acid metabolism, a potential source of cellular OH, with nordihydroguaiaretic acid and 5,8,11,14-eicosatetraynoic acid (ETYA) resulted in marked inhibition of NK cell activity. Inhibition of the cyclooxygenase pathway with acetylsalicylic acid or indomethacin had minimal effects on NK cell activity. Taken together, these findings suggest that OH, possibly generated via the lipoxygenase pathway of arachidonic acid metabolism, is critical for NK cell cytotoxicity.

Arachidonic Acids↗