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Biomedical subjects

K H Schulz

Publications and source records attributed to K H Schulz.

At least 37 records · Page 2Linked to original sources
PubMed1986

Induction of contact dermatitis in guinea pigs by quaternary ammonium compounds: the mechanism of antigen formation.

Eight quaternary ammonium compounds were tested for their ability to induce contact dermatitis in guinea pigs by using a modified Freund's complete adjuvant test together with the guinea pig maximization test. Only two quaternary ammonium salts of the eight tested could be designated as strong allergens. These two active substances were shown to be capable of stable association with membrane lipids in forming immunogenic complexes. This surface complexation phenomenon was confirmed by using a spin-labeled quaternary ammonium salt which competed for binding sites at the surface of epidermal cells in vivo. Electron spin resonance was used to demonstrate that stable "ion-pairs" are formed between binding sites and the two allergenic preservatives. Furthermore, information was obtained on the kinetics of immunogenic complex formation as well as on the position and orientation of the quaternary ammonium ion at the cell surface.

Allergens↗
PubMed1984

[Allergy to dyes in stockings].

Skin allergies caused by the wearing of stockings and hose have received little attention. Findings in patients of an allergy department, enquiries at stocking counters of stores and recent publications indicate, however, that probably many more persons have an allergy to stocking dyes than is generally thought. Skin tests with isolated stocking dyes indicate that azo dye dispersion yellow 3, dispersion orange 3 and dispersion red 1 are the most important contact allergens. They were demonstrated in 18-21 of the 23 hose examined. In textile materials, azo dye dispersion blue 124 is predominant among allergens. Cross-reactions may occur to other dispersion azo dyes, used in cosmetics, textiles, toiletries and hygenic articles, permitted food additives and hair dyes. It is suggested that in persons who have dye allergy or intolerance, decolouration followed by colouring with natural colours be undertaken.

Allergens↗
PubMed1984

[Photoallergic reaction to carprofen].

Carprofen, a non-steroidal anti-inflammatory drug of the arylpropionic acid derivative type, can provoke both phototoxic and--as in the reported case--photoallergic reactions.

Aged↗
PubMed1983

[Urticaria].

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Chronic Disease↗
PubMed1982

[Colophony allergy. A contribution to the origin, chemistry, and uses of colophony and modified colophony products, 1].

Colophony (rosin) derives from pine resin, tall oil and stump extractives. It is used as is or in chemically modified forms: hydrogenated, disproportionated, esterified, polymerized, as salt or reacted with maleic anhydride or formaldehyde. One of the largest single uses is in the sizing of paper and paperboard. There are hundreds of opportunities for a person to become exposed to colophony and modified products and thus sensitized to it, for example by contact with adhesive tapes, soaps, coating of price labels, eye shadow, periodontal and surgical dressings, furniture polish, glues, musician's rosin, printing inks, printing paper surfaces (newspapers), rubber, plastics etc. The main sensitising components seem to be abietic acid and Abitol (a mixture of different hydroabietyl alcohols). Dermatitis has been described in more than 60 articles; epidemiological studies demonstrate an increasing number of cases since 1980. As wood rosin has been replaced in recent years more and more by tall oil rosin, which is different in its composition, it is recommended to remove the colophony of the standard series (which is derived from pine gum) and to replace it by a mixture of pine, tall oil and stump rosin to diminish the number of probably missed allergic reactions.

Chemical Phenomena↗
PubMed1981

[Diphenylcyclopropenone - a new strong contact sensitizer (author's transl)].

A new synthetic substance - diphenylcyclopropenone - has been proven to be responsible for contact dermatitis in three persons handling it in chemical laboratories. A student of chemistry developed a dermatitis of the hands that lasted for more than two months. Based on the case history this dermatitis was considered to be an allergic one. The sensitizing capacity of diphenylcyclopropenone was proven experimentally in guinea pigs by use of the open epicutaneous sensitization method. All 25 animals became strongly sensitive. Sensitization could also be induced by a single application of low concentrations, for example with 3% in acetone. Cross-reactions could be elicited in the sensitized animals by intermediate produts and the synthesis like alpha, alpha'-dibromdibenzylketone and the remaining procduct called "red oil". The intermediate product is a mixture of racemic d- and l-forms and a meso-form as well, whereas the "red oil" consists of polymerized carbonyl compounds, from which diphenylcyclopropenone is extracted with boiling cyclohexane. Risk of contact with the sensitizer is greatest in the last step of synthesis. Care should not only be taken while handling this new substance in chemical laboratories, but contact should also be avoided with the intermediate and end products in cases where a diphenylcyclopropenone contact allergy is present.

Adult↗
PubMed1979

["Malabsorptive" dermatitis herpetiformis. A study with particular regard to biopsy findings of the small intestine (author's transl)].

21 patients (6 females and 15 males) with Dermatitis herpetiformis have been studied with special considerations of the small intestinal biopsy-findings. During this investigation the patient's mean age was 45 years (20-68) and the mean age at onset was 38 years (17-64). In 5 patients (23.8%) total villous atrophy (group I) and in 4 patients (19.0%) a severe partial or subtotal villous trophy (group II) was found on small intestinal biopsy. The sprue-like changes were patchy lesions. Histocompatibility-antigens of type HLA-AL were found in 38.1% and of type HLA-B8 in 47.6%. After 20 years of the disease one patient died of a malignant lymphoma of the intestine (immunoblastic sarcoma). In all patients the number of interepithelial lymphocytes in the small bowel mucose was significantly increased, as it was in those patients with a normal villous pattern (group III). In a quantitative analysis of specifically labeled (peroxidase-anti-perosidase complex) IgG-, IgA- and IgM-cells in the intestinal mucosa it was found that the number of all three plasma cell classes are increased significantly (P less than 0.01).

Adult↗
PubMed1979

The sensitizing capacity of naturally occurring quinones. Experimental studies in guinea pigs. II. Benzoquinones.

Experimental studies on the sensitizing capacity of naturally occurring benzoquinones, isolated from plants and woods have been carried out in guinea pigs of the Pirbright white strain. Seven compounds were available: primin, three dalbergiones, mansonia quinone (mansonone A), 2,6-dimethoxybenzoquinone and rapanone. With five of these substances (primin, mansonone A, three dalbergiones) guinea pigs could be sensitized. Primin, the allergen of Primula obconica Hance (primrose) proved to be the most effective one of all quinones tested in this and the preceding studies. As a similar but weaker sensitizer R-3, 4-dimethoxydalbergione from Machaerium scleroxylon Tul. (Pao ferro, Caviuna vermelha) could be identified. The results obtained with mansonone A, a sesquiterpenoid quinone from Mansonia altissima A. Chev. demonstrate that even naturally occurring orthoquinones are capable of inducing contact allergy. Allergic cross reactions could be obtained between all chemically related mansonones A-F. The results are in good accordance with the view that the sensitizing capacity of naturally occurring quinones depends on the fundamental quinoid structure and the length, position and configuration of the aliphatic side-chain.

Animals↗
PubMed1978

[Immunofluorescence test in the diagnosis of mushroom worker's lung (author's transl)].

Growing and harvesting a new edible mushroom (Pleurotus florida mushroom--oyster mushroom) liberates a high amount of spores the inhalation of which causes symptoms similar to those of "farmer's lung". The Ouchterlony test detects precipitins against antigens of the spore membrane only in cases with high serum antibody levels, i.e. only one in eight sufferers from the disease had a positive antibody test. Because of this, indirect immunofluorescence was used as a more sensitive method for serum antibody detection: all mushroom workers with clinical symptoms were found to have precipitating antibodies. The test is, therefore, superior to the Ouchterlony one, is simpler and saves time. Furthermore, the immunoglobulin class can easily be obtained at the same time.

Alveolitis, Extrinsic Allergic↗
PubMed1978

Occupational allergic contact dermatitis due to leatherleaf fern Arachniodes adiantiformis (Forst) Tindale.

Leatherleaf fern has been imported from the United States, Honduras and Puerto Rico to the Federal Republic of Germany since 1966 and cultivated in Germany since 1970/71. It is slowly displacing the floral arrangements with asparagus used until now as filler and background material. This change is due primarily to its better keeping quality. Continuous contact with the leatherleaf fern induced an allergic contact dermatitis of the palms and fingers in a female florist. Patch tests with the leaf revealed the allergic origin of the dermatitis. Five fractions of a chromatographically separated extract of the fern were tested on sensitized guinea-pigs and on the patient. Only the first fraction gave a positive patch test response. By further separation colourless crystals of the contact allergen could be obtained. Elucidation of the structure is in progress. The sensitizer could only be detected during sporogenesis of the fern, that means when sporecapsules are present on the surface of the leaves.

Adult↗
PubMed1978

[Polyvalent contact allergy in a florist].

A female florist, who ran a flowershop from 1954 to 1966 had to quit her job because of her known contact allergy due to chrysanthemums and primrose. Though in the meantime 12 years had passed she suffered occasionally from redness of the pharynx and stomachache after ingestion of tea prepared from yarrow and camomile. Cleaning off her garden from weeds and frequently followed by swelling of her face and pruritus. After epicutaneous testing she developed positive reactions to chrysanthemum as well as cross reactions to sunflower, arnica, camomile, yarrow, tansy, mugwort and frullania (this lichen does not occur in the Northern part of Germany). Patch test with primin revealed the persistence of the highgrade hypersensitivity to Primula.

Adult↗