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K H Schicketanz

Publications and source records attributed to K H Schicketanz.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Regional chemotherapy of liver metastases of colorectal carcinoma using implanted gas pressure pumps. Results of a prospective phase II study].

22 patients with liver metastases of colorectal carcinomas were given floxuridine infusions into the hepatic artery using a totally implantable pump system (Infusaid, model 400). The course of the disease was compared to that of 22 untreated controls matched for age, sex, extent of metastatic disease and performance status. No therapy-related mortality was observed in the treatment group, morbidity was 37%. Response rate was 77% based on CEA decrease by more than 33% after 6 months, and 64% related to a more than 50% reduction in metastasis size. Median survival time was 10 months in the control group as compared to 26 months in the therapy group; the one-year survival rate was 37.5% and 88%, respectively.

Adult↗
PubMed1986

The influence of ossein-hydroxyapatite compound ('Ossopan') on the healing of a bone defect.

A study was undertaken in 60 adult rabbits in order to determine the effects of ossein-hydroxyapatite compound on bone healing. Standardized bony defects were produced in the distal femoral epiphyses, after which animals were randomized into four equal groups. An untreated group served as a control. One group received ossein-hydroxyapatite compound, 830 mg per day, a second group received bone mineral (ossein-hydroxyapatite compound reduced to ash, to remove organic constituents), 510 mg per day, and a third group received calcium carbonate, 650 mg per day. A series of fluorescent vital markers was administered to the animals from the 7th to the 32nd day after production of the defect. A third of the animals in each group were sacrificed 35, 56 and 84 days, respectively, after induction of the defect. Histological sections of the region of the bone defect were examined with a fluorescence microscope and resulting photomicrographs were scored with respect to degree of fluorescence, nature and degree of defect filling and structure of the newly formed bone. All three active treatment groups resulted in significantly improved mineralization as compared with the untreated control group. Treatment with ossein-hydroxyapatite compound, but not the other two active treatments, resulted in significant improvements in the pattern and quality of bone healing, particularly when assessed at 56 or 84 days after induction of the bone defect. These results indicate that ossein-hydroxyapatite compound has a beneficial effect on the process of bone healing but that this effect is lost if the organic components of the compound are destroyed or if pure calcium carbonate treatment is substituted. This strongly suggests that organic components of ossein-hydroxyapatite compound have osteogenic effects, enhancing the utilization of the mineral intake, and is consistent with previous experimental findings. It is suggested, therefore, that ossein-hydroxyapatite compound has considerable clinical potential and should be regarded as having specific, sophisticated effects on bone metabolism, rather than as a simple dietary mineral supplement.

Animals↗
PubMed1984

CT-analyses of cerebral tumors under steroid therapy.

In order to determine, by CT density and volume measurements, the influence of steroid therapy on cerebral tumors, on their perifocal edema and on the uninvolved cerebral tissue, CT follow-up studies of 37 patients were analysed. In general a decrease of tumor density is to be seen within the first 10 days of therapy. Under continuous steroid application absorption coefficients then increase again, so that no cortisone effect on the tumor remains. The tumor size does not alter: in particular at no time is growth retardation detectable under cortisone therapy. Intensity and extension of the perifocal edema decrease in two stages. From this delayed course we conclude the cytotoxic component of the tumor edema to be more extensive than supposed. Deviations appear dependent on tumor histology, which should lead to individualized steroid application.

Astrocytoma↗
PubMed1983

[Incidence of hospitalizations and operations for ulcer disease 1970-1981].

Since 1970 there has been a slight reduction, since 1977 a marked one, in the number of admissions for peptic ulcer at the two medical and the surgical clinics of the University of Mainz. This trend was interrupted by a peak from 1975-77, due to an increase of overall admissions at that time, after vagotomy procedures had been started at the surgical clinic. The reduction in admissions only related to uncomplicated ulcer and the admissions to the surgical clinic. Admissions for ulcer complications and to the medical clinics remained unchanged. The reduction in the number of operations for uncomplicated duodenal ulcer was 62%, for uncomplicated gastric ulcer 60%. Operative mortality rate for the former was 1.6%, for the latter 1.86%, while it was 10-25% for ulcer complications.

Duodenal Ulcer↗
PubMed1983

Metabolic changes in the rat liver during pregnancy. II. Tricarboxylic acid cycle.

During pregnancy the rat liver shows alterations in metabolism which apparently do not to occur in the non-pregnant animal. In our study, the following metabolite concentrations and enzyme activities in the liver of pregnant and non-pregnant rats were measured after fasting periods of 6 and 12 h: malate, fumarate, isocitrate, alpha-keto-glutarate, glutamate, malate-dehydrogenase, fumarate-hydratase, glutamate-dehydrogenase, isocitrate-dehydrogenase, aspartate-aminotransferase and after 12 h fast, the concentrations of acetyl coenzyme A and citrate. These results are discussed with regard to their possible importance for the maternal and fetal energy supply.

Animals↗
PubMed1982

Measurements of the volume and density of intracerebral tumors by CT following therapy.

For the interpretation of curative measures in patients with cerebral tumors CT is of increasing importance. The therapeutic effects can be demonstrated by close follow-up studies without any of the disadvantage of invasive neuroradiological methods. Our investigations of 125 patients with cerebral tumors are based on volume and density determinations. The CT studies of removed or inoperable tumors followed by radiation and/or cytostatic therapy prove that the best results follow a combination of both. In the present cases however, if CT proves postoperatively, at the end of radiation or at the beginning of the application of cytostatics that there is a residual mass, a complete remission cannot be obtained.

Astrocytoma↗
PubMed1976

[Epidemiological studies of P. aeruginosa infections by the typing of pyocine sensitivity (author's transl)].

A standardizing by means of determination of the pyocine sensitivity could be achieved on the basis of 200 strains of P. aeruginosa which had been isolated out of clinical material. It was analyzed semiquantitatively by using a step-scale in five parts. The identical or in a high degree corresponding strains according to the pyocine sensitivity could be registered on the example of the isolated strains of a intensive-care unit by the calculation of the Q-correlation coefficient according to the Q-technique as well as by the determination of the differences in the single reactions using a standardized measure of distance. The epidemiological connexion resulting from that is discussed.

Bacteriocins↗