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Biomedical subjects

K H Frank

Publications and source records attributed to K H Frank.

51 records · Page 3Linked to original sources
PubMed1983

[Serologic determination of non-A, non-B hepatitis].

As to the antigens of hepatitis non-A non-B there are controversial opinions concerning existence and demonstrability. Up to now they were not successful neither in standardizing nor in unifying their test systems. On the basis of own investigations of 1,600 sera of patients with hepatitis non-A non-B and of several control groups, no doubt, a high incidence of precipitations among the sera of hepatitis non-A non-B could be established, but we did not succeed in standardizing the material which was uniform also with regard to the causing virus. Since real antigen-antibody reactions are causative for the heterogeneous phenomena, there nature is to establish by means of suitable methods (methods of the 3rd generation, monoclonal antibodies).

Antigen-Antibody Complex↗
PubMed1983

[Immunohistologic findings in the liver, spleen, brain and skeletal muscles in fatal cholestatic viral hepatitis (following double infection with hepatitis B and non-A/non-B?)].

We report immunohistological findings in liver, spleen, brain, and skeletal muscle of a 23-year-old woman with hepatitis nonA/nonB caused by contaminated anti-D-globulin. She died in a liver coma. At autopsy, a chronic liver dystrophy with cirrhosis was diagnosed. The necrotic areas of the liver showed a collapse of the reticulin framework, newly formed collagen fibres, and diffuse inflammation with immunohistological evidence of IgG, CIq, C9, and fibrinogen. C4 and C9 could be localised in bile thrombi and in the cytoplasm of pseudotubular transformed hepatocytes. In addition, C9 was found in blood vessel walls. A local distribution of HBsAg was found in the cytoplasm and/or the periphery of liver cells. HBcAg could not be detected in any of 5 different regions of the liver. A serum with antibodies to acute phase antigen of nonA/nonB hepatitis stained the cytoplasm and nuclei of (mostly intact) liver cells focally and their cell membranes diffusely. Patchy deposits of IgA and IgM were demonstrated in liver, brain und spleen. Circulating antibodies to cell nuclei and smooth muscle reacted with the patient's own liver and brain but not with spleen and skeletal muscle.--It is suggested that the manifold immunohistological findings in this patient are an expression of the vain attempt of the organism to clear away antigenic material, probably induced by different hepatitis viruses.

Adult↗
PubMed1981

[Epidemiology, clinical aspects, immunology and morphology of non-A, non-B hepatitis].

Examinations were carried out in a population group of 106 potentially contaminated females and in five donors, affected one year earlier within the frames of a restricted epidemic, caused by NANB-hepatitis virus. It was possible to differentiate a specific antibody-antigen system, identical to that of sirahi et al. The antigen was confirmed in 20 per cent of the females, 21 per cent of the contaminated did not get ill. The high SGPT level came in the foreground in the rest; 38 per cent had the signs of cholestasis. After one year, high transaminases were found in 43 per cent of the diseased, and biopsically--a chronic persistent hepatitis was found or a hepatitis with low activity. The chronification tendency correlates with the favourable clinical findings during the initial acute phase. The patients with prodromal phenomena, high transaminases and cholestasis showed a tendency to noncomplicated course and completely healing. The extraparenteral infection was confirmed, being conditioned by the close contact between mother and child or during breast feeding on one hand, on the base of the clinical manifestations, and biopsically--on the other.

Antibodies, Viral↗
PubMed1979

[Demonstration of hepatitis A virus in the feces].

On the basis of own examinations methodology and results of the demonstration of the virus A in the stools and of the proof of antibodies in the serum are described. The parameters of the virus-A-hepatitis which are important for practice are further the basis for diagnosis, therapy and surrounding prophylaxis in routine work. They were compiled in a table.

Adult↗