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Biomedical subjects

K H Beyer

Publications and source records attributed to K H Beyer.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Hydrochlorothiazide-induced 131I excretion facilitated by salt and water.

Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl- to I- excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl- excretion, I- reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled I-excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced I-excretion rate as much as eight-fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three- to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs.

Animals↗
PubMedDate not supplied

Metabolism of nafronyl in man.

The metabolism of nafronyl (I) has been studied in man. In addition to small amounts of the parent compound, three acidic metabolites were extracted from urine. The chemical structures of all metabolites were determined by using mass spectrometry and [1H]-NMR spectroscopy as tetrahydro-beta-(1-nephthalenylmethyl)-2-furanpropionic acid (II) and two stereoisomers of 3-(1-naphthalenylmethyl)-tetrahydrofuran-2-one-5-propionic acid (III, IV). The biodegradation products III and IV are formed after oxidation of the tetrahydrofuran system in II, hydrolytic ring opening of the gamma-butyrolacton and a subsequent formation of a gamma-butyrolacton ring with the second carboxyl group. The three metabolites represent the major fraction of unconjugated products in the urine of man after administration of nafronyl.

Adult↗