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Biomedical subjects

K Grossmann

Publications and source records attributed to K Grossmann.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Long-term results of PTA of degenerative supra-aortic arterial changes].

We present our experience with 129 patients in whom PTA was performed in 135 stenosed or occluded supra-aortic arteries. Angioplasty was successful in 44 stenoses of the carotid artery, 19 stenoses of the vertebral artery, 5 stenosis of the innominate artery, 53 stenoses of the subclavian artery and 4 occlusions of the subclavian artery. There were only 4 minor-complications (2 haematomas, 1 TIA, 1 small thrombus of the internal carotid artery which was detected by 111-indium platelet scintigraphy) and 1 major-complication (permanent hemiparesis). During the observations period of 1 to 116 months (average 61 m) there were only two cases with re-stenosis after subclavian angioplasty. The results suggest that angioplasty of supra-aortic arteries is an effective method.

Angioplasty, Balloon↗
PubMed1991

[Use of light reflex rheography in diagnosis of chronic venous diseases].

The light reflexion rheography is described as non-invasive investigation method for the venous system. The basic principle of the method and its applications are explained as well as its evaluation and the peculiarities which are to be taken into consideration thereby are discussed in detail. The comprising evaluation of the haemodynamic changes in chronic diseases of the veins is particularly elucidated by the method with regard to an improvable chronic venous insufficiency and to the differentiation between epifascial and subfascial pathological changes on the venous system. The method is suitable for the differentiation of the possible forms of therapy as well as for the examination of the result of the treatment. By means of this method a judgment of the efficacy of preparations for vein diseases is not possible. At the earliest the technique is comparable with the bloody measurement of the venous pressure-phlebodynamometry. Its smaller exactness should be compensated by triple measurement. The possibilities of errors as well as the advantages of the method and its areas of application preferred are discussed in detail. The light reflexion rheography is nowadays together with the ultrasound Doppler diagnostics a technique of diagnostics which should be present in every phlebologic practice.

Humans↗
PubMed1990

[Possibilities and limits of pharmacotherapy of chronic venous insufficiency].

The conservative therapy of the chronic venous insufficiency is always carried out with etiopathogenetic orientation and according to the stages of disease. Of the medicamentous therapy oedema-protective and vein-tonicising drugs, oral anticoagulants and non-steroidal antiphlogistics are discussed. Furthermore, the alternative and supplementary prescription of physiotherapy and movement cure depending on findings is dealt with.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1990

[Expert assessment of chronic venous insufficiency].

In the expertise of a chronic venous insufficiency kind and stage of the venous disease must be proved as objectively as possible. The diagnostic demands in the individual step programmes serve for the exact assessment of the remaining part of efficiency. The criteria of valuation are summarized, in which case we also deal with several possibilities of combination with other vascular diseases. The expert opinion of an accident is discussed. References to the inability to work, rating of nursing money, increased material benefit in impairments of health and to the acknowledgement of an identity card for injured persons supplement the statements.

Disability Evaluation↗
PubMed1990

[Comparison of plethysmography findings before and following varicose vein surgery].

In the chronic venous insufficiency on the basis of a primary varicosis the occlusion plethysmography of the veins is a suitable remedy in the positioning trial before and after a combined phlebectomy to determine the capacity of the venous part of the circulation on the lower extremity. In altogether 160 patients the functional capacity of the venous valves with the initial inclination to swelling St as well as the capacity of the venous vascular system on the calf and the ankle were established by the determination of the maximal venous capacity Vmax. It could be proved that particularly in stage III of the chronic venous insufficiency the haemodynamically most effective efficacy can be achieved by an operation of the varices.

Female↗
PubMed1990

Tracer kinetics of 15-(ortho-123/131I-phenyl)-pentadecanoic acid (oPPA) and 15-(para-123/131I-phenyl)-pentadecanoic acid (pPPA) in animals and man.

The human myocardium retains oPPA as opposed to pPPA. Therefore turnover of oPPA was compared with that of pPPA in rat hearts and in man, the latter by using substrates double-labeled with 123/131I and 14C. Moreover, substrate binding to coenzyme-A was tested in vitro. In rats, oPPA remained mainly in the pool of free fatty acids, as opposed to pPPA, which was metabolized by mitochondrial beta-oxidation. Binding to coenzyme-A at maximum was 62% for oPPA, 81% for pPPA and 90% for palmitic acid. In man, after i.v. and intracoronary injection of double-labeled oPPA, the two radionuclides reappeared together in venous blood and in coronary sinus respectively, in an unchanged ratio but at a significantly lower rate than with pPPA. It can be concluded that oPPA is bound to coenzyme-A and is retained in the cytosolic lipid pool, while pPPA is metabolized by mitochondrial beta-oxidation. A dual-tracer application of oPPA and pPPA has the potential of being a specific probe for the function of the carnitine shuttle.

Animals↗
PubMed1988

Ethylene production by sunflower cell suspensions : effects of plant growth retardants.

From a variety of undifferentiated plant cell suspensions, 2,4-dichlorophenoxyacetic acid-dependent cells of sunflower (Helianthus annuus L. Spanners Allzweck) produced large quantities of ethylene. The maximum rate was about 1 nanomole x gram fresh weight(-1) x hour(-1) during the exponential growth phase. The action of various compounds known to interfere with ethylene formation in plant tissue was studied in sunflower cell suspensions. The influence on ethylene, 1-aminocyclopropanecarboxylic acid (ACC), and N-malonyl-ACC (MACC) levels suggested that the final steps in ethylene synthesis resemble those of other plant systems. This makes sunflower cells suitable for analyzing the effects of biologically active compounds on cellular ethylene biosynthesis. In particular, plant growth retardants of the norbornenodiazetine and triazole type inhibited ethylene production of sunflower cells. On the other hand, the ACC level was considerably elevated while that of MACC did not change significantly. It is assumed that the conversion of ACC to ethylene catalyzed by the ethylene-forming enzyme was influenced.

Journal Article↗
PubMed1987

[Computer analysis of peripheral pulse curves].

The methodical fundaments as well as the technical solutions for a technique of the computerized analysis of non-invasively registered peripheral arterial pulse curves are demonstrated. Hereby a quantitative analysis of the pulse curves using new and significant evaluation parameters is performed as well as a reference to the probability diagnosis for the total estimation of the pulse curve is given. The technique is realised in form of a mobile microcomputer measuring place and allows an automatic registration, evaluation documentation and recording of rheograms and pulse oscillograms, respectively immediately at the patient's bed and is suited for a broad application in the angiological preliminary and special diagnostics.

Computers↗
PubMed1987

Percutaneous transluminal angioplasty (dilatation) of carotid, vertebral, and innominate artery stenoses.

Over a period of 5 years, 51 stenoses of brachiocephalic arteries were successfully dilated, and one subclavian occlusion recanalized in 42 patients. Among 24 patients there were 21 stenoses of the internal carotid artery, two stenoses of the common carotid artery, two stenoses of the innominate artery, five stenoses at the origin of the vertebral artery, and four stenoses of the subclavian artery. There were 17 patients who had stenoses of the subclavian artery. In 12 cases several arteries were affected. In 9 patients multiple (2-3) stenoses in these supraaortic arteries were dilated. In 4 cases bilateral dilatation of internal carotid arteries was performed. There were transient, minor complications in 2 patients.

Aged↗
PubMed1987

Regulation of plant morphology by growth retardants: effects on phytohormone levels in soybean seedlings determined by immunoassay.

The effects of the growth retardants tetcyclacis, a norbornenodiazetine, and LAB 150 978, a dioxanylalkenyl triazole, on seedling growth and endogenous levels of phytohormone-like substances in Glycine max L. cv Maple Arrow were studied. The levels of phytohormone-like substances in the root and in the various shoot tissues were analyzed by immunoassay. After seed treatment with both compounds, shoot growth was reduced more intensively than root growth. Both compounds decreased, on a fresh weight basis, the amount of various immunoreactive gibberellins when compared with the levels in control plants, especially in the shoot tip. Likewise, the growth retardants lowered the levels of abscisic acid-like material, particularly in the primary leaf, the epicotyl and the root. In contrast, the levels of trans-zeatin-riboside and dihydrozeatin-riboside-type cytokinins were considerably elevated by the growth retardants, mainly in the primary leaf, epicotyl, and hypocotyl. On the other hand the level of isopentenyladenosine-like material was less influenced. In general, the immunoreactive 3-indoleacetic acid content in the different plant parts was changed only slightly. It is assumed that besides their effect on gibberellin content both compounds interfere directly or indirectly with the regulation of the endogenous levels of abscisic acid and cytokinins. This might be seen as an additional mode of action of growth retardants explaining some side effects on developmental processes of treated plants, e.g. delayed senescence and enhanced chlorophyll concentration in the leaves.

Journal Article↗
PubMed1986

[Results of percutaneous transluminal dilatation of cerebral vascular stenoses].

The present paper is a review of 37 successful catheter dilatations of supra-aortic vascular stenoses. There were sixteen patients with a total of 21 stenoses of the internal carotid, vertebral artery or common carotid artery and sixteen patients with subclavian stenoses. Amongst the patients with stenoses of the cerebral vessels, there were ten with multiple lesions and six with a single stenosis. Three patients had successful dilatations of bilateral stenoses. The indications, technique, and complications of catheter dilatation of lesions of the cerebral vessels are described and discussed.

Adult↗
PubMed1986

[Percutaneous transluminal dilatation (PTD) of descending stenoses of the vertebral artery].

38 stenoses of supra-aortic arteries were dilated with good success in 32 patients over a period of four years. They were 17 stenoses of the internal carotid artery, one of the common carotid artery, 16 of the subclavian artery, and four descending stenoses of the vertebral artery. Indication, method, and results of percutaneous transluminal dilatation of stenoses descending from the vertebral artery are described and discussed, with reference being made to case examples.

Angioplasty, Balloon↗