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Biomedical subjects

K Green

Publications and source records attributed to K Green.

At least 343 records · Page 19Linked to original sources
PubMed1975

Prostaglandins in the human endometrium. Gas chromatographic-mass spectrometric quantitation before and after IUD insertion.

Prostaglandin F2alpha and its major metabolite in plasma, 15-keto-13, 14-dihydro-PGF2alpha were quantitated in biopsies from human endometrium using gas-liquid chromatography-mass spectrometry. In four of the five cases studied, the levels of both compounds were higher in the secretory phase than in the proliferative phase regardless of whether the IUD was present or not. Before insertion of an IUD the levels of PGF2alpha ranged from 65 to 8,280 pg. per milligram of tissue and those of 15-keto-13,14-dihydro-PGF2alpha ranged from less than 4 to 1,940 pg. per milligram. After insertion of an IUD the levels of the compounds ranged from 260 to 2,100 and from 5 to 109 pg. per milligram, respectively. In four of the five individual cases the IUD caused a decrease rather than an increase of the prostaglandin content of the tissue. These data do not indicate an increased biosynthesis of prostaglandins in the human endometrium after insertion of an IUD.

Adult↗
PubMed1975

Ocular penetration of pilocarpine in rabbits.

Aqueous humor pilocarpine hydrochloride concentration was measured at 15, 30, 60, and 120 minutes after instillation in the rabbit eye of a radioactively labeled 2% pilocarpine solution in various vehicles. Maximum concentrations were found with a vehicle containing 1.67% polyvinylpyrrolidone and other water-soluble polymers (Adsorbotears) and 1% hydroxypropyl methylcellulose. These produced pilocarpine concentrations during the first two hours after administration three times greater than those found with either saline, 1.4% polyvinyl alcohol, or 0.5% hydroxypropyl methylcellulose. Benzalkonium chloride, 0.01%, enhanced pilocarpine penetration into the aqueous by as much as 50% at all time intervals. The vehicle viscosity was unrelated to efficacy of pilocarpine penetration into the aqueous. The equally effective 1% hydroxypropyl methylcellulose and Adsorbotears have viscosities of 112 and 20 centistokes, respectively, while 0.5% hydroxypropyl methylcellulose (13 centistokes), 1.4% polyvinyl alcohol (3 centistokes), and sodium chloride solution (0.85 centistokes) are much less efficacious.

Animals↗
PubMed1975

Prostaglandin analogues and uterotonic potency: a comparative study of seven compounds.

The uterotonic potency of seven prostaglandin analogues has been investigated using the single intravenous injection technique and comparison of threshold uterine contractility achieved during continuous intravenous infusion. The degree and duration of uterine stimulation in response to graded doses of some of the analogues was also evaluated following intra-amniotic, oral and vaginal administration. 17-Phenyl substituted PGE-2 and PGF-2alpha are reported upon for the first time. Among the prostaglandin compounds tested, the free acid of 16, 16-dimethyl PGE-2 not only is the most potent compound but it may also have great potential for clinical application as an easily administered vaginal abortifacient.

Abortion, Induced↗
PubMed1975

The effect of benzalkonium chloride on the electropotential of the rabbit cornea.

The effect of benzalkonium chloride on the electropotenial of the cornea has been examined. The anterior surface of the in vivo or in vitro cornea was exposed to various concentrations of the surfactant, from 0.005% to 0.02%, for either 1 or 2 min. The initial effect is a hyperpolarization lasting up to 30 sec, followed by a rapid fall in potential difference with a subsequent recovery. The degree of potential difference decrease and the recovery rate was dependent upon both the concentration of the detergent, and the exposure time. There is excellent correlation between the previous anatomical and physiological studies on tracer penetration across the in vivo and in vitro cornea and our present work. The data indicate that benzalkonium chloride acts by breaking down the physiological and anatomical diffusion barrier to solute and solvent which is located in the outer layer of the epithelium.

Animals↗
PubMed1975

Prostaglandins.

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Adipose Tissue↗
PubMed1975

Pattern of ocular response to topical and systemic prostaglandin.

Changes in both intraocular pressure and total outflow facility were determined after short- and long-term infusion and topical application of prostaglandin E1 and E2. The intraocular pressure with both routes of administration increased within 15 minutes by 10 to 15 mm. Hg; long-term infusion caused the intraocular pressure to be elevated for a longer time, although a fall in intraocualr pressure occurred despite continued infusion. Total outflow facility did not increase until 30 minutes after initiation of treatment and thereafter increased further with time, irrespective of the route of drug application. The initial increase in intraocular pressure is suggested to be the result of vascular changes, namely an increase in the leakiness of the iris vessels and the capillary pressure of the ciliary body vessels caused by the vasodilatory actions of prostaglandins.

Administration, Topical↗
PubMed1975

Ocular effects of diacetyl morphine and lysergic acid diethylamide in rabbit.

Intravenous lysergic acid diethylamide (LSD) given to rabbits in doses from 1 to 100 mug per kilogram of body weight produced a dose-related increase in intraocular pressure and outflow facility. Minor changes in systemic blood pressure were observed, but respiration rate was accelerated, and mydriasis became pronounced at higher doses. Diacetyl morphine (heroin) was given intravenously in doses from 0.1 to 2 mg. per kilogram of body weight. A dose-related decrease in intraocular pressure and an increase in outflow facility was found. A dose-related miosis was observed and at higher doses respiration became markedly depressed. Neither drug alters the permeability of the isolated ciliary epithelium. Both drugs appear to increase capillary blood pressure and, hence, aqueous humor inflow to cause the intraocular pressure to be maintained at approximately normal levels in face of increases in outflow facility of 50 per cent.

Anesthesia, Intravenous↗