[Determination of collagen peptidases in animal tissues].
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Animals↗
Biomedical subjects
K Grasedyck
Publications and source records attributed to K Grasedyck.
[The value of morphology in the diagnosis of chronic polyarthritis].
The clinician's question concerning the value of morphological findings in diagnosis of rheumatoid arthritis is answered by the pathologist. After a short discussion of clinical problems and the ARA-criteria, at first the diagnostic importance of synovial cytology in RA is dealt with. The patient's history, biopsy technique and methods are the most important prerequisites of an optimal assistance of the pathologist to a definite diagnosis; they are reviewed in short paragraphs. These data are the bases of the morphological evaluation which is discussed in detail. This is the most important part of the answer to questions of the clinician; the pathologist is not only able to verify the clinical diagnosis of rheumatoid synovitis or of RA but often he may decisively judge the course and activity of the disease and the therapeutic success.
Arthritis, Rheumatoid↗
[Autoradiographic studies on the mitotic and productive metabolism of the articular cartilage in mouse genetic arthritis].
With suitable radioactively labelled precursors the mitotic (using 3H-thymidine) and the productive metabolisms (using 3H-proline and 35S-sulphate) were investigated on various kinds of joint- etc. cartilage from mice with genetically caused arthrosis. The autoradiographic analyses were performed using 3H-thymidine-, 3H-proline- and 35S-sulphate-indices and the statistical evaluation of the findings led to the following results: the synthesis level of sulphated glycosaminoglycans (GAG) in the cartilage ground substance is lower for 5--6 month-old mice than for the 16--17 month-old animals of this genetic arthrosis strain. This is most distinct in the 3rd (= basal) zone of the knee-joint cartilage which increased to double the comparable value in this period. In all 3 zones of the knee-joint cartilage GAG-synthesis is considerably greater than the collagen synthesis according to these autoradiographic analyses. These findings can be detected before any histologically or histochemically demonstrable cartilage alterations and represent therefore the earliest signs of a so-called "pre-arthrosis". Collagen synthesis decreases thereby, and the same holds for DNA-synthesis and the mitotic metabolism of the cartilage cells - according to the findings to date. However the question is still under investigation whether arthrosis (like atherosclerosis) also starts with an increase in cell-turnover. This question is not only of theoretical interest, it has practical clinical consequences, even for the treatment. These investigations also serve this clinically relevant question because arthrosis is the most common human joint disease.
Animals↗
[Apolar acting collagen peptidases of different rabbit organs and their modification by thymectomy and experimental arthritis].
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Animals↗
[Combination therapy in chronic polyarthritis].
Long-term effects of disease-modifying antirheumatic drugs are not at all satisfactory. Therefore combinations of different substances have long been studied. But no convincing recommendations could be derived from those results. Some combinations seem to be more effective than the single substances, but often have more side-effects. First of all, those types of rheumatoid arthritis must be defined which require an aggressive therapy. These may profit from combinations with sulfasalazine, methotrexate or azathioprine. But such questions may only be answered by long-term studies which can be statistically evaluated.
Antirheumatic Agents↗