Search PubMed⌕ Search

Biomedical subjects

K Goto

Publications and source records attributed to K Goto.

At least 1,009 records · Page 56Linked to original sources
PubMed1977

A comparison of the electrical properties and morphological characteristics of the smooth muscle of the rat and guinea-pig vas deferens.

Microelectrodes were used to compare a variety of electrophysiological parameters of the rat and guinea-pig vas deferens. In comparison to the guinea pig, spontaneous junction potentials in the rat tissue were of shorter duration and occurred with greater frequency and amplitude. Action potentials induced by nerve stimulation could be observed in the smooth muscle of both species. However, in the rat tissue the majority of action potentials were generated in the impaled cell while 60% of the action potentials in the guinea-pig vas deferens were propagated. When current was intracellularly applied, spike potentials could be induced in approximately 90% of the cells of the rat vas deferens but in less than 10% of the cells of the guinea-pig vas deferens. The space constant was 1.48 mm for the guinea-pig vas deferens, but less than 0.5 mm for the rat vas deferens. Electromicroscopic examination of the homologous tissues indicates that the differences in electrical properties can be accounted for in part by differences in morphology. The incidence and intimacy of neuromuscular contacts was greater in the rat vas deferens while the incidence of nexuses between smooth muscle cells was greater in the guinea-pig tissue.

Animals↗
PubMed1977

Synthesis and adrenergic beta-blocking activity of some 1,3-benzodioxole derivatives.

A series of 1,3-benzodioxole derivatives was synthesized. We found four compounds (2,3,10 and 11 in Table IV) to have about the same order of beta-blocking activity as that of sotalol. In addition, it is of interest that some of the compounds (2-4) were found to have hypotensive activites, although they were about one-tenth of that of hydralazine. Sotalol did not produce any change in blood pressure, and propranolol raised the blood pressure.

Adrenergic beta-Antagonists↗
PubMed1977

Determination of the left ventricular volume by scinticamera --basic studies and clinical application--.

Scintillation angiocardiography was performed around the point of time when the injected RI mainly passed through the left ventricle. Gating permitted the radiophotography of the end-diastolic and end-systolic image of the left ventricle. Critiques of the techniques gave result that the best available image could be obtained when the cumulative count was 20,000, aperture setting 4/5 and brightness of cathode ray tube 8. Studies with mechanical model showed that the condition of high-flow, combined with the use of relatively small dose of RI resulted in a marked underetimation of the left ventricular image. Clinical studies was performed using SWI-LVEDV plots, giving the plot of stroke index (SWI) against the left ventricular end-diastolic volume (LVEDV). It was thus formed that the patients with enlarged left ventricles responded to the administration of digitalis with shrinkage of the heart, while the patients with relatively small heart responded to it with increase in SWI at the unchanged level of LVEDV. Studies with systolic time intervals particularly PEP/LVET, showed that relatively high values of PEP/LVET applied to those whose left ventricular SWI-LVEDV plots were located low and to the right, while relatively low values of PEP/LVET applied to those patients whose SWI-LVEDV plots were located high and towards the left, indicating relatively good LV performance.

Adult↗
PubMed1977

Isolation of a cell line insensitive to growth-restricting action of dextran sulfate from 3t6 cells.

In the medium containing dextran sulfate, 3T6 cells stopped growth at almost monolayer stage and showed decreased saturation density. This action of dextran sulfate is referred to as a growth restriction. About 70% of untreated 3T6 cells formed piled-up colonies whereas the remaining 30% formed monolayer colonies. Fraction of the latter increased with increasing concentration of dextran sulfate in the medium. Cell lines sensitive and insensitive to the growth-restricting action of the compound were cloned from colonical culture of the wild type cells. Sensitive cells showed a slightly less saturation density than the wild type cells in the presence of dextran sulfate. Insensitive cells grown in dextran sulfate medium showed almost the same growth rate and saturation density as the untreated wild type cells grown in the absence of the compound.

Animals↗