Search PubMed⌕ Search

Biomedical subjects

K Goto

Publications and source records attributed to K Goto.

At least 847 records · Page 47Linked to original sources
PubMed1986

[A clinical study of primary hyperparathyroidism].

Eight cases of primary hyperparathyroidism (P-HPT) confirmed pathohistologically, between April, 1974 and January, 1986 at our department, were reviewed. The patients consisted of three males and five females, ranging in age from 38 to 62 years old with an average of 50.3 years. All the cases belonged to the urolithiasis type and seven patients were recurrent or/and multiple stone-formers. Positive rates of the laboratory values studied in relation with P-HPT were 100% in serum Ca, C terminal parathyroid hormone, and % TRP, 87.5% in urine Ca, 75% in serum Cl/P ratio, alkaliphosphatase, 50% in serum Cl, 37.5% in serum P and 0% in urine P. Seven cases had clinically apparent hypercalcemia, while one was a so-called borderline P-HPT with intermittent hypercalcemia. The correct diagnosis of the localization was obtained preoperatively in two cases by angiography and one by C.T and Tl-Tc subtraction scintigraphy. Histological findings of the tumors extirpated by the cervical operation were parathyroid adenomas in six cases and hyperplasia in two. During the course of the postoperative follow up, hypercalcemia and urolithiasis did not recur in any case including two of hyperplasia.

Adult↗
PubMed1985

Biochemical modeling of an autonomously oscillatory circadian clock in Euglena.

Eukaryotic microorganisms, as well as higher animals and plants, display many autonomous physiological and biochemical rhythmicities having periods approximating 24 hours. In an attempt to determine the nature of the timing mechanisms that are responsible for these circadian periodicities, two primary operational assumptions were postulated. Both the perturbation of a putative element of a circadian clock within its normal oscillatory range and the direct activation as well as the inhibition of such an element should yield a phase shift of an overt rhythm generated by the underlying oscillator. Results of experiments conducted in the flagellate Euglena suggest that nicotinamide adenine dinucleotide (NAD+), the mitochondrial Ca2+-transport system, Ca2+, calmodulin, NAD+ kinase, and NADP+ phosphatase represent clock "gears" that, in ensemble, might constitute a self-sustained circadian oscillating loop in this and other organisms.

Animals↗
PubMed1985

Computed tomography of cerebral infarction along the distribution of the basal perforating arteries. Part I: Striate arterial group.

Computed tomographic (CT) manifestations of cerebral infarction along the distribution of the basal perforating arteries were reviewed in correlation with cerebral angiography. Infarcts in the territories of perforators were demonstrated individually based on knowledge of their three-dimensional distribution as demonstrated by microangiography of cadavers. In Part I of the study, the areas supplied by the medial (MSA) and lateral striate arteries (LSA) were examined. Infarction along the branches of the MSA usually involved the antero-inferior portion of the corpus striatum, immediately posterolateral to the most inferior part of the frontal horn of the lateral ventricle. Infarcts along the branches of the LSA abutted the territory of the MSA posteriorly and superiorly and involved the posterolateral region of the corpus striatum. Clinical and neuroradiological correlations are discussed.

Cadaver↗
PubMed1985

Computed tomography of cerebral infarction along the distribution of the basal perforating arteries. Part II: Thalamic arterial group.

Computed tomographic (CT) manifestations of cerebral infarction along the distribution of the basal perforating arteries were reviewed and correlated with cerebral angiography. Infarcts in the territories of perforators were demonstrated individually based on knowledge of their three-dimensional distribution as shown by microangiography of cadavers. In Part II of the study, the posterior areas supplied by the thalamic arteries were examined. Infarcts in the area supplied by the thalamotuberal arteries involved the anterior pole of the thalamus; those in the area of the thalamoperforate arteries involved the medial portion of the thalamus, along the lateral wall of the third ventricle; those in the area of the thalamogeniculate arteries involved the posterolateral portion of the thalamus; and those in the area of the choroidal arteries of the lateral ventricle involved the most posterolateral and dorsolateral portions of the thalamus. Clinical and neuroradiological correlations are discussed.

Arteries↗
PubMed1985

[Effect of traxanox on antibody formation in C57BL/6 mice].

C57BL/6 mice, lower responders to sheep red blood cells (SRBC), were intraperitoneally immunized with 5 X 10(8) SRBC on day 0. Traxanox (10 and 30 mg/kg) administered orally on days 0 and 1 potentiated the production of spleen- and thymus-rosette forming cells (RFC) assessed on day 7. The production of hemolytic plaque forming cells (HPFC) to SRBC in the spleen of the syngeneic recipient mice assessed on day 4 was inhibited by the transfer of spleen-RFC obtained from the vehicle-treated donor mice, but not by that obtained from the traxanox (30 mg/kg)-treated donor mice. The same results were obtained in the thymectomized-recipient mice. The activity of the spleen-RFC obtained from the vehicle-treated donor mice was abolished by treatment with anti-Thy 1.2 or anti-Lyt 2.2 antibody and complement. On the other hand, the activity of the spleen-RFC obtained from the traxanox-treated donor mice was abolished by treatment with anti-Lyt 1.2 antiserum and complement. Traxanox (3 and 30 mg/kg) also caused the induction of the Thy 1.2-positive RFC in the spleen of the thymectomized mice. These results suggest that traxanox has a capacity to potentiate the immune responses to SRBC in C57BL/6 mice by the induction of Lyt 1.2-positive cells (helper T cells).

Adjuvants, Immunologic↗
PubMed1985

Effects of gonadotrophins on progesterone production by isolated granulosa cells of the adenohypophysectomized domestic fowl (Gallus domesticus).

Ovine LH and ovine FSH stimulated progesterone production in granulosa cells isolated from the F1, F2 and F3 follicles of hypophysectomized and control (sham-operation) hens when they were collected 6 h after operation, but the steroidogenic response to LH was greater for granulosa cells from hypophysectomized hens. At 15 h after operation progesterone production by granulosa cells was stimulated by LH in all 3 follicle types of control hens, but only in the F1 follicles of hypophysectomized hens. The response to FSH at 15 h was similar for control and hypophysectomized hens. The time after hypophysectomy therefore appears to affect the LH-stimulated progesterone production by granulosa cells of the F2 and F3 follicles.

Animals↗