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Biomedical subjects

K Gopal

Publications and source records attributed to K Gopal.

27 records · Page 2Linked to original sources
PubMed1985

Role of neurotransmitters in endosulfan-induced aggressive behaviour in normal and lesioned rats.

Normal and lesioned rats exposed to 3 mg/kg i.p. endosulfan for 10 subsequent days showed elevated foot-shock fighting behaviour in septal and nigral brain-lesioned animals. Increased ipsilateral circling was noticed in unilateral-nigral lesioned rats. A marked decrease in locomotor activity and no seizure pattern were recorded in rats treated with chlorpromazine (CPz). Electroencephalographic recording on the tenth day of endosulfan exposure showed high-voltage slow activity (HVSA) with occasional spindles and 5-6 Hz amplitude of 200 microV. In the treated rats an increase in the concentration of dopamine (DA) and a decrease in serotonin (5-HT) were recorded in amygdaloid, septal and nigral brain-lesioned rats.

Aggression↗
PubMed1981

The acute toxicity of endosulfan to fresh-water organisms.

A static bioassay is performed for measuring the short-term (96 h) toxicity of endosulfan to juvenile catfish Clarias batrachus, insect nymph Enallagma sp. and frog tadpoles of Rana tigrina. Median Tolerance Limit, Slope Function, Confidence Limit, and Presumable Harmless Concentration were computed. The results showed that frog tadpoles are more susceptible to endosulfan than insect nymph and catfish. Morphological changes and behavioural alterations were evaluated as symptoms of endosulfan toxicity.

Animals↗
PubMed1981

Bromocriptine therapy in acromegaly. A long-term review of 35 cases.

Bromocriptine (CB-154, Parlodel, Sandoz) was given to 35 acromegalic patients for a period of 6-36 months. Basal and post-therapy endocrine functions including estimation of serum growth hormone (GH) profile; and GH kinetics during oral glucose tolerance test, augmented insulin tolerance test and thyrotrophin releasing hormone test were determined. The pituitary tumour size was delineated by a pneumoencephalogram. The mean GH levels ranged from 14 micrograms/l to 316 micrograms/l. Bromocriptine suppressed GH values to 5 micrograms/l or less in 16 patients and less than 10 micrograms/l in a further 6 patients. In 33 patients GH values fell to 50% of the basal value or less. There was no significant GH reduction in 2 'nonresponders'. Bromocriptine did not block the stress-induced GH secretion. It did not disturb pituitary functions other than prolactin which was suppressed much earlier and was maintained with smaller doses. GH suppression on the other hand was shortlived and rebounded when the drug was omitted. It had no adverse effect on tumour size in 2 patients having suprasellar extension of the tumour. Bromocriptine improved carbohydrate tolerance and sexual function although it did not affect insulin and gonadotrophin values. It seems reasonable to offer a trial of bromocriptine in all patients with acromegaly where therapy is deemed necessary as it is well tolerated, has insignificant side effects and no adverse drug interactions. Its high cost and prolonged course are obvious disadvantages. Caution should be exercised in cases with suprasellar extension and visual field involvement.

Acromegaly↗
PubMed1981

Pituitary apoplexy (spontaneous pituitary necrosis).

Pituitary apoplexy or spontaneous pituitary necrosis is an ill-understood clinical syndrome. It may occur as a neurological emergency requiring urgent interference in a patient with a known pituitary dysfunction or it may be responsible for drawing attention to an as yet unrecognized pituitary pathology. It has a bizarre clinical profile and an unpredictable neurological and endocrine course. Patients may die at once or may recover with or without endocrine/neurological deficit. Six cases of pituitary apoplexy with varied clinical presentation are cited.

Adenoma, Chromophobe↗
PubMed1980

Effect of endosulfan of bioelectrical activity of brain in rats.

Bioelectrical activity of rat brain was studied after administration of endosulfan (5 mg/kg, ip) for 10 days. The pesticide produced rhythmic bursts of spikes and waves of seizure pattern that started 25-30 minutes after dosing and persisted for 60-minutes. The clonic convulsions were more marked over the head region and were mainly localized in the upper extremities. Histopathologic examination of the liver showed congestion of the central veins and its adjacent sinusoids. Concentration of the compound in brain parallelled the electrical activity.

Animals↗