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Biomedical subjects

K Glaser

Publications and source records attributed to K Glaser.

At least 73 records · Page 4Linked to original sources
PubMed1989

"Reversible gastric banding" in surgical treatment of morbid obesity--results of animal experiments.

The basic principle of "reversible gastric banding" as a new surgical approach to morbid obesity treatment is the creation of a small fundus reservoir using a silicone cuff which is coiled around the stomach close to the cardia. The extent of obstruction corresponds to the amount of liquid in the cuff which can be varied by puncture of a valve implanted in the subcutis. The reversibility of gastric obstruction is the great advantage of this method as compared to vertical banded gastroplasty or gastric bypass. We studied this method in animal experiments using seven "Göttinger Minipigs". In two animals the objectives of the study were reached, the observed complications, mostly caused by the nature of the test animal, are analyzed and discussed. To our knowledge, this is the first report in the literature on animal experiments in bariatric surgery.

Animals↗
PubMed1988

Synchronous adenocarcinoma of the transverse colon, the gallbladder and the vermiform appendix.

According to the literature synchronous adenocarcinomas of both, the colon and the gallbladder or the colon and the appendix are extremely unusual. To our knowledge the simultaneous occurrence of all three tumors has never been published before. Preoperative diagnosis of early stage tumors of the gallbladder and the vermiform appendix is also made very seldom. The following case report records an instance of synchronous adenocarcinomas of the gallbladder, the transverse colon, in a colonic polyp and the appendix. Owing to the patient's advanced age simultane cancer occurrence may be mere coincidence. Nevertheless, this extremely rare entity could also be ascribed to a genetic defect or an unknown carcinogenic agent.

Adenocarcinoma↗
PubMed1987

[Intraoperative radiotherapy of malignant pancreatic tumors--initial results].

Thirteen patients suffering from adenocarcinomas of the pancreas were submitted to an intraoperative fast electron "boost" therapy with or without percutaneous photon irradiation. A duodeno-cephalo-pancreatectomy with subsequent irradiation of the tumor bed could be performed in three patients. Ten patients were inoperable because of advanced tumors and formation of metastases. The average survival is 6.5 months, at present six patients are alive without major troubles. An analgetic effect was obtained in ten patients. The first results are encouraging with respect to local control, the little acute and chronic morbidity, and palliation achieved in advanced stages.

Adenocarcinoma↗
PubMed1986

[Intraoperative radiation treatment of carcinoma of the pancreas. Initial clinical results].

Intraoperative radiotherapy (IORT) was administered to 13 patients with carcinoma of the pancreas, using high-velocity electrons of a LINAC accelerator in a single dose of maximally 25 Gy applied directly to the tumour or tumour bed with the abdomen open. There were no disorders of wound healing or other serious early complications which could be ascribed to the radiation. Stomach and intestines were excluded from the radiation field to avoid late radiation damage, such as stenoses or ulcers. The method is particularly indicated for locally non-resectable, non-metastasized pancreatic carcinoma, possibly also as tumour-bed radiation during radical surgery. Patients with distant metastases were not given radiation. First results point to IORT providing lasting improvement of pancreatic pain. It is too early to know whether survival time is favourable influenced.

Aged↗
PubMed1984

Attenuation by d-ozolinone of l-ozolinone-induced diuresis in rats.

The effect of the non-diuretic dextrorotatory isomer of ozolinone on l- ozolinone -induced diuresis was studied in anesthetized rats. After intravenous application d- ozolinone attenuated l- ozolinone -induced increase in renal fluid, sodium, potassium and chloride excretion. Microperfusion experiments of the loop of Henle in vivo revealed that no interaction between the two stereoisomers occurred at this main site of tubular action of l- ozolinone . Since both isomers share the same organic acid transport pathway in the proximal tubule it is assumed that d- ozolinone attenuates the l- ozolinone -induced diuresis because it depresses proximal secretion of l- ozolinone and thereby partially prevents transfer of this diuretic to the tubular fluid.

Animals↗
PubMed1981

Psychopathologic patterns in depressed adolescents.

Depression in adolescents may be masked by symptoms not commonly found in adults. These symptoms may require, at least initially, a management approach not necessarily in the best interest of treatment of the underlying depression. Suicidal behavior in adolescents can be manipulative and unrelated to depression. Management of such adolescents must differ from the management of patients whose suicidal behavior is the direct result of depression.

Adolescent↗
PubMed1980

Studies with the optically active isomers of the new diuretic drug ozolinone. I. Differences in stereoselectivity of the renal target structures of ozolinone.

The renal actions of the optically active isomers of the new diuretic drug ozolinone were studied by clearance, flowmeter and micropuncture techniques in rats. The levorotatory, but not the dextrorotatory isomer of ozolinone increased urine flow, urinary sodium and chloride excretion and enhanced sodium and chloride concentrations in early distal tubular fluid as checked by in situ microperfusion of Henle's loops. This indicates stereospecificity of the drug's diuretic action. However, both isomers of ozolinone equally inhibited maximal tubular secretion of paraaminohippurate and increased renal blood flow as measured by an electromagnetic flowmeter. Thus, the different renal target structures of ozolinone differ markedly with respect to stereoselectivity.

Animals↗
PubMed1978

The treatment of depressed and suicidal adolescents.

Loss and abandonment and distortions of the self-image have special significance for the causation and treatment of depression during adolescence. The management of the manipulative suicidal adolescent and some psychological aspects of pharmacotherapy during this developmental phase are discussed. An eclectic approach is recommended.

Adjustment Disorders↗