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Biomedical subjects

K Ghosh

Publications and source records attributed to K Ghosh.

At least 253 records · Page 14Linked to original sources
PubMed1988

Hereditary persistence of foetal haemoglobin in northwest India.

1561 consecutive adult patients who were not suffering from any haematological or malignant disorder and 40 healthy volunteers were screened for hereditary persistence of foetal haemoglobin (HPFH). Two unrelated heterozygotes were detected. Both these heterozygotes displayed heterocellular distribution of foetal haemoglobin in 14-18% of red cells constituting 3.1-4.3% alkali resistant foetal haemoglobin. No case of pancellular variety of HPFH was detected. The heterocellular variety of HPFH is present in 1:800 individuals in Northwest India.

Adolescent↗
PubMed1988

Serum and leukocyte lactate dehydrogenase activity in leukaemias.

Lactate dehydrogenase (LHD) content of serum and leukocytes was examined in 42 haematologically normal healthy volunteers and in 34 patients suffering from various types of leukaemia. All patients were studied at the time of presentation and before any therapeutic intervention. Serum LDH was elevated in all types of leukaemia. In acute myeloid leukaemia (AML) a significant elevation of leukocyte LDH activity (p less than 0.005) was noted. In acute lymphoblastic leukaemia leukocyte (ALL), LDH was significantly elevated when compared to normal lymphocyte LDH (p less than 0.01) levels, but not when compared to total normal leukocyte LDH levels. In chronic leukaemias, leukocyte LDH levels were not significantly different from the normal. Comparison of LDH isoenzyme pattern in peripheral blood cells with that of serum, both in normal and in leukaemia cases showed more "M" type enzyme in the cells than in the serum. However, the "M" type enzyme was significantly elevated only in AML cases (p less than 0.005). Serum LDH and peripheral blood leukocyte count compared in normal subjects and in leukaemia cases showed no correlation.

Adult↗
PubMed1986

Plasma transcobalamins in haematological disorders.

Plasma UBBC-B12 and transcobalamins were measured in 112 patients suffering from different haematological disorders. The data showed different patterns of changes in plasma transcobalamin profile in different haematological disorders. Plasma UBBC-B12 and transcobalamins were significantly higher than normal in untreated chronic myeloid leukaemia, acute promyelocytic leukaemia, nutritional megaloblastic anaemia and in refractory anaemias with hypercellular marrow. Normal levels of these proteins were noted in chronic lymphatic leukaemias, in primary and secondary hypereosinophilic states and in multiple myeloma. Subnormal levels of these proteins were observed in hypoplastic anaemia and acute lymphoblastic leukaemia. Chronic myeloid leukaemia patients during blast crisis and acute myeloid leukaemia patients except those suffering from acute promyelocytic leukaemia showed varying pattern of plasma transcobalamins depending on type of blast crisis or FAB subtype of AML. The significance of these changes in plasma transcobalamins have been discussed along with the experience of other workers in this field.

Anemia↗
PubMed1986

Glycosylated haemoglobin (Hb A1) in normal rhesus monkeys (Macaca mulatta).

Glycosylated haemoglobins were measured in 23 healthy juvenile rhesus monkeys by the use of commercially available minicolumn chromatography (Quick Sep., Isolab Inc., Ohio, USA) to establish the normal range. Values obtained (mean +/- 1 standard deviation (SD) 1.57 +/- 0.68%) were significantly lower than that of 17 adult healthy human volunteers by the use of the same method of estimation (mean +/- 1 SD of 5.34 +/- 0.78%).

Animals↗