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Biomedical subjects

K Gerlach

Publications and source records attributed to K Gerlach.

45 records · Page 3Linked to original sources
PubMed1984

[Pharmaceutic and biopharmaceutic evaluation of acetylaminonitropropoxybenzene (Falimint). A Biotransformation of the active agent].

2-Acetamino-4-nitropropoxybenzene is metabolized almost completely. Till now in urine of man seven components have been detected. The main way of metabolism is the oxidation of the propoxy group to a carboxyl group. Also the deacetylated compound of this acid has been found to a certain extent. A further metabolite is supposed to be oxidized in the side chain in another way. In a higher extent dealkylation to 2-acetamino-4-nitrophenol takes place which is eliminated probably in conjugation with glucuronic acid. Free 2-acetamino-4-nitrophenol and 2-amino-4-nitrophenol respectively are only detectable in traces. Deacetylation of 2-amino-4-nitropropoxybenzene takes place only in a very small extent. Till now metabolites with reduced nitro group haven't been found.

Acetanilides↗
PubMed1983

[Pharmaceutical and biopharmaceutical evaluation of acetylaminonitropropoxybenzolum (Falimint). 3: Polarographic analysis and determination of active agents].

According to its aromatic nitro group acetylaminonitropropoxybenzene (Falimint) can be determined polarographically. The typical behavior of the nitro group becomes evident by the elektrochemical reduction. The investigation has shown two phases of reduction with pH-depended half-wave-potential shifts, so that a two-step mechanism is conceivable. Using direct current polarography the substance is determined in a concentration range from 1 to 100 micrograms/ml. Low elektroaktive background signals within the potential range the four-electron reduction step are the basis for the determination of the active agent in saliva, urine and blood plasma without any extracting procedures. It is possible to identify the substance by means of oscilloand square-wave-polarography. The resulting polarogrammes are typically for the p-nitrophenyl structure. Further a new quantitativ polarographic method, named sample-DC-polarography on the stationary mercury electrode is discussed for the determination of Falimint in blood plasma without any steps of separation and cleaning in the concentration range of 0,1-3,0 micrograms/ml.

Acetanilides↗
PubMed1982

[Experiences with ambulatory group psychotherapy].

It has been reported about the results of ambulatory psychotherapy in groups. We believed that the process in a group will be stimulated specifically by different concepts and kinds of intervention. Thus, the behaviour of the therapeut seems to be very important. Special attention is also paid to the preparation of the patients within a complex therapy programme. In this way it is possible, also to improve ambulatory ability and indication of dynamie psychotherapy in a group.

Ambulatory Care↗
PubMed1980

[Chronobiological aspects of artificial total heart replacement in long-term animal experiments--a systemanalytic study (author's transl)].

Biological rhythms (circadian rhythms) have been observed in the hemodynamics of experimental animals (calves). After artificial total heart replacement these rhythms are typically altered compared to control animals. These observations induce a growing consideration of chronobiological aspects in a systemanalysis for the conception of an automatic external control of the artificial heart, which has to be divided in:--parameter-progression (tendencies), --parameter-variation (discrete, oscillations), --parameter-coupling (phase shifts).

Animals↗