[Diagnostic significance of autoantibodies in pemphigus in cases of clinically doubtful diagnosis].
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Biomedical subjects
Publications and source records attributed to K Gede.
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The presence of anti-HIV antibodies was sought in 1061 patients (818 men and 243 women) with various sexually transmitted diseases; the group of men contained 29 homosexuals (3.5%) and 26 were bisexual (3.2%). Together these deviants accounted for 7.1% of the group. EIA test confirmed with the Western-blot test gave positive result in 11 patients, including 10 homosexual and bisexual men, that is in 18.2% of the subgroup of men with this deviation, and in 1 heterosexual man (0.13%). Over one-half of them had or had had syphilis, and in the subgroup of homosexuals the patients with syphilis amounted to 36%. The proportion of HIV infections in homosexuals, patients of outpatient clinics for sexually transmitted diseases, is much higher than in heterosexual patients in these clinics and homosexuals not treated in these clinics. Patients in outpatient clinics for sexually transmitted diseases are a high risk group for HIV infection (especially homosexuals with syphilis) and should be tested for the presence of anti-HIV antibodies.
Potassium penicillin G was administered intravenously 4 times daily in doses of 6 million u for 10 days to 49 patients, 36 with central nervous system syphilis and 13 with latent seroresistant syphilis. Forty six patients were followed up after treatment. In 16 patients with central nervous system syphilis treated by this method another cerebrospinal fluid examination was done. Cerebrospinal fluid changes regressed completely in 13 patients, in three cases the improvement was incomplete. The titres of VDRL and FTA tests decreased in 23 patients with central nervous system syphilis and in 11 with latent seroresistant syphilis. In eight patients treated by this method seroresistance persisted and in four cases the titre fluctuated. The results of the study demonstrate the effectiveness and advantages of the treatment of central nervous system syphilis and latent seroresistant syphilis with crystalline penicillin administered intravenously.
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