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Biomedical subjects

K G Wulle

Publications and source records attributed to K G Wulle.

At least 19 recordsLinked to original sources
PubMed1995

MR T2 relaxation time for the assessment of retrobulbar inflammation in Graves' ophthalmopathy.

The results of 39 patients with severe Graves' ophthalmopathy (GO), who were monitored by magnetic resonance imaging (MRI) and tonography before and after combined immunosuppressive treatment with cyclosporine and corticosteroids, are presented. A correlation was found between the decrease in T2 relaxation time of the superior, medial, and inferior rectus muscle (p < 0.01) and the response to the immunosuppressive treatment. Muscle thickness and intraocular pressure showed less improvement (p < 0.05). The infiltrative eye signs improved partially in correlation with the T2 relaxation time. By distinguishing inflammation of the extraorbital muscles from fibrosis, the T2 relaxation time can help to select patients that benefit from immunosuppressive treatment as well as to monitor the therapeutic effect.

Adrenal Cortex Hormones↗
PubMed1988

[Results of nuclear magnetic resonance tomography studies in endocrine orbitopathy].

Magnetic resonance imaging (T1- and T2-weighted) was performed in 65 patients with Graves' disease. In addition, T2 relaxation times of each ocular muscle were measured. Of the muscles thus studied, 54.8% showed a thickening in coronary tomograms. An interaction between the optic nerve and the thickened ocular muscles at the apex of the orbit was suspected in 30.1%. It could not be confirmed that the thickening of the muscles and the T2 value were related. However, there was a high correlation between the rise in intraocular pressure and the T2 relaxation time. These results imply that the T2 relaxation time is extremely useful in interpreting the activity of Graves' disease and provide a diagnostic tool of prognostic value in monitoring and treating this disease.

Adolescent↗
PubMed1987

[Gaze-fixation tonometry or tonography in endocrine ophthalmopathy].

In patients with Graves' ophthalmopathy there is often a rise in intraocular pressure (dIOP) in changing from straight-ahead gaze to upgaze. If dIOP is measured using the applanation tonometer of the slitlamp, mistakes occur in pressure recording. In order to check these mistakes the authors compared tonometric with tonographic records of dIOP in 90 eyes of 45 patients. It was found that tonographic values were twice as high as tonometric values. Therefore, tonography furnishes more information about the activity of Graves' disease than tonometry; the errors of measurement associated with tonometry are also avoided.

Fixation, Ocular↗
PubMed1987

Ciamexon-treatment in endocrine ophthalmopathy.

In severe cases of e.o. IV to VI combined treatment with Cyclosporin A and corticosteroids is most effective whereas Ciamixon alone appears to be less effective. Patients who received Ciamexon some time after termination of Cyclosporin A treatment showed slight ophthalmological improvement or stabilization of the status (judged after short time of therapy). Patients with e.o. III (IV), treated ineffectively with only corticosteroids before, showed a tendency of improvement under Ciamexon treatment.

Adjuvants, Immunologic↗
PubMed1986

[Significance of fundus evaluation in the staging of hypertensive disease compared to electrocardiography and renal circulation].

In order to determine the relevance of ophthalmoscopic findings in cases of hypertension as compared to electrocardiographic abnormalities and disorders of the renal function, the authors examined 728 patients admitted to the German diagnostic Clinic (Wiesbaden) with hypertension over a period of 2 years. In all cases blood pressure was measured twice, and ophthalmoscopy, electrocardiography, a chest X-ray, and a laboratory checkup were performed. The effective renal plasma flow was measured in 100 cases using the 131 iodine-Hippuran clearance method. The results revealed that ophthalmoscopy is the most reliable method for classifying early and more advanced stages of hypertension, as compared to ECG and measurement of the effective renal plasma flow.

Electrocardiography↗
PubMed1985

Treatment of severe Graves' ophthalmopathy with cyclosporin A.

Ten patients with severe Graves' ophthalmopathy, resistant to other therapeutic regimens were treated with cyclosporin A (CyA) over a period of 6 months. Clinically, 9 patients improved, 2 of them only after addition of corticosteroids. Intra-ocular tension on upward gaze decreased in all of these 9 patients (P less than 0.01). In 6 patients there was a significant decrease in eye muscle thickness under the treatment (P less than 0.05) as determined by computerized tomography. Side effects (e.g., paraesthesia, proteinuria) which were observed under higher doses of CyA, disappeared after lowering the dose. In only one out of 3 patients with hypertension an antihypertensive medication became necessary. CyA appears to be a valuable drug for treatment of severe Graves' ophthalmopathy when previous therapeutic regimens turned out to be unsuccessful.

Antibodies↗
PubMed1984

[Diagnostic procedure in uveitis patients to determine general concomitant disorders].

A thorough examination, planned jointly by an internist and an ophthalmologist, is advocated for patients with uveitis. Close cooperation with all medical subspecialties is mandatory in order to save the time and money of both the physician and the patient. One or more relevant concomitant diseases were diagnosed in 79 patients out of a total of 206 who came to the Deutsche Klinik für Diagnostik, Wiesbaden, for an investigation of their uveitis.

Bacterial Infections↗
PubMed1980

[Interdisciplinary diagnosis and treatment of endocrine orbitopathy (Graves' disease) (author's transl)].

Diagnosis and treatment of Graves' Disease requires in close cooperation between ophthalmologists, nuclear physicians and radiotherapists. Following detailed thyroid diagnostics, a prerequisite to balancing thyroid function, measures may be taken against eye and orbita changes, in accordance with the degree of severity of the disease. A classification of Graves' disease demands careful ophthalmological diagnosis, supplemented by sonography and computer tomography of the orbita. Corresponding to the stages of the disease described, therapeutic measures are outlined; these consist essentially of systemic cortico-steroid treatment, high-voltage radiation of the retrobulbar space, prism therapy and surgery of the muscles.

Exophthalmos↗
PubMed1978

Electron microscopy of the early embryonic development of the human corneal epithelium.

The eyes of a human embryo in the 6th week, 11 mm crown-rump (C.R.) length, and of a human embryo in the 7th week, 19 mm C.R. length, were examined. In the embryo of 11 mm C.R. length, the lens vesicle had just detached from the surface ectoderm, the presumptive corneal epithelium. The acellular primary corneal stroma appeared between the lens vesicle and the overlying ectoderm. The fine structure of the ectodermal cells, of their basal lamina, and of the primary stroma is described. In the embryo of 19 mm C.R. length, mesenchymal cells had moved from the periphery into the space between the ectoderm and the lens. There were remarkable changes in the structure of the corneal epithelial cells, in their basal lamina, and in the underlying substances of the primary stroma.

Cornea↗
PubMed1978

[Applanation tonometry within medical diagnostic "check-up" programs (author's transl)].

Within medical diagnostic "check-up" programs intraocular pressure measurements by applanation tonometry from 8899 patients (5924 men, 66.6%; 2975 women, 33.4%) were statistically evaluated. The frequency of each i.o. pressure show no Gaussian distribution but is skewed to the right with marked excess to higher values of i.o. pressure. Correlation of mean i.o. pressure with age shows (starting in the group of the 20-24 years old to the 75-79 years old persons) a rather linear progression of i.o. pressure. The mean value of i.o. pressure (n = 17,798 eyes) was x = 16.25 mm Hg, the standard deviation +/- 3.45, the standard deviation of the mean +/- 0.03 mm Hg. In men in 2.18% in women in 1.81% higher i.o. pressure than 21 mm Hg was found. I.o. pressure higher than 24 mm Hg have 0.66% of the men and 0.58% of the women. Patients forty years old and elder showing in 4.92% of the men and 4.88% of the women higher i.o. pressure than 21 mm Hg. In patients fifty-five years old and elder in 5.75% of the men and respectively in 6.69% of the women i.o. pressure higher than 21 mm Hg was found. Incidences of elevated i.o. pressure from patients over forty years old in ten years steps are presented. In 103 patients with unilaterally i.o. pressure higher than 24 mm Hg 12% presents manifest diabetes mellitus. The usefullness of applanation tonometry as a practicable screening method for early glaucoma detection within medical diagnostic "check-up" programs is outlined. Advantages of data-aquisition and -processing systems to continue those studies are emphasized.

Glaucoma↗
PubMed1977

[Statistical contribution on symptomatic dry eye].

Optical mark page reader forms to establish the case history were statistically evaluated with regard to the question 'Do you often have the feeling of having sand in the eye. Out of a total of 5,833 patients, 684 (11.7%) answered this question with 'yes'. Women stated with 15.1% relatively more often than men with 9.7% this clinical symptom. Of these 684 patients who subjectively complained of feeling of sand, 241 had an ophthalmological examination. In 92 patients (38.2%) the Bengal-Rosa 1% test was specifically performed due to the specific past history and the clinical symptoms stated on questions by the physician; in all cases signs of a keratoconjunctivitis sicca of different degree were found by slit-lamp microscopy, i.e., at least 4.5% keratoconjunctivitis sicca patients on our whole collective can be expected. The result of a thorough examination in these 92 patients (39 men and 53 women) with ophthalmologically confirmed keratoconjunctivitis sicca showed that in 25 (of 53) women there was an imbalance of the sex hormones. Besides degenerative diseases due to age, diseases of the connective tissue and those caused by an auto immune mechansim were found.

Adult↗