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Biomedical subjects

K G White

Publications and source records attributed to K G White.

At least 37 records · Page 2Linked to original sources
PubMed1988

Low dose scopolamine affects discriminability but not rate of forgetting in delayed conditional discrimination.

The effect of scopolamine on remembering was examined in a delayed conditional discrimination procedure with rats. Remembering was quantified by a negative exponential function fitted to estimates of discriminability derived from a signal detection type of analysis. This function had two parameters: a measure of initial discriminability of the sample stimuli in the absence of a memory requirement (at zero delay) and a measure of rate of forgetting. Eight rats were trained on an auditory delayed conditional discrimination task until they were showing stable performance. Each rat then received doses of 0, 0.005, 0.014, 0.042, 0.125 and 0.375 mg/kg scopolamine IP in a saline vehicle. There was a highly significant, largely linear, decrease in initial discriminability. This was obvious even at the lowest dose of scopolamine. Poorer memory, as demonstrated by an increase in b, was only apparent at the highest dose. Significant changes in per cent of correct responses were also only obtained at higher doses. These results show that initial discriminability and rate of forgetting are pharmacologically as well as theoretically independent. They suggest that the measure of initial discriminability used here is a particularly sensitive measure of at least some types of cholinergic dysfunction; and they also suggest that effects of scopolamine in other working memory tasks could be more a result of changed stimulus processing than of impairment of memorial processes.

Animals↗
PubMed1987

Sensitivity to reinforcer duration in a self-control procedure.

In a concurrent-chains procedure, pigeons' responses on left and right keys were followed by reinforcers of different durations at different delays following the choice responses. Three pairs of reinforcer delays were arranged in each session, and reinforcer durations were varied over conditions. In Experiment 1 reinforcer delays were unequal, and in Experiment 2 reinforcer delays were equal. In Experiment 1 preference reversal was demonstrated in that an immediate short reinforcer was chosen more frequently than a longer reinforcer delayed 6 s from the choice, whereas the longer reinforcer was chosen more frequently when delays to both reinforcers were lengthened. In both experiments, choice responding was more sensitive to variations in reinforcer duration at overall longer reinforcer delays than at overall shorter reinforcer delays, independently of whether fixed-interval or variable-interval schedules were arranged in the choice phase. We concluded that preference reversal results from a change in sensitivity of choice responding to ratios of reinforcer duration as the delays to both reinforcers are lengthened.

Journal Article↗
PubMed1986

Conjoint control of performance in conditional discriminations by successive and simultaneous stimuli.

In a conditional discrimination, reinforcement of pigeons' responses to pairs of simultaneously presented wavelength stimuli depended on the orientation of white lines superimposed on the wavelengths. Over different conditions in Experiment 1, three wavelength differences were combined with two differences between successively presented line orientations. Measures of stimulus discriminability increased with increases in the difference between both orientation and wavelength stimuli. Conditional-discrimination performance was thus conjointly determined by stimulus disparity in the successive and simultaneous discriminations. In Experiment 2, ratios of rates of reinforcement contingent upon the two categories of correct responses were varied over several conditions for difficult and easy discriminations. Ratios of responses to wavelength pairs were sensitive to variations in the reinforcement ratio to a greater extent for the more difficult orientation discrimination than for the easier orientation discrimination. Performance in the conditional discrimination was therefore determined by the interacting effects of stimulus disparity and the relative rates of reinforcement contingent upon the two correct choices. It was concluded that the effect of temporally distant reinforcement on behavior in a prevailing schedule component is attenuated to an extent that depends on similarity of stimuli that delineate the successive components.

Animals↗
PubMed1985

Interresponse-time analysis of stimulus control in multiple schedules.

Interresponse-time distributions were recorded in two components of multiple variable-interval schedules that were varied over several conditions. Values of the exponent for power functions relating ratios of interresponse times emitted per opportunity to ratios of reinforcers obtained in the two components varied with interresponse-time class interval. The exponent (sensitivity to reinforcement) afforded a measure of stimulus control exerted by the discriminative stimuli. Exponents were near zero for short interresponse times, consistent with previous conclusions that responses following short interresponse times are controlled by response-produced or proprioceptive stimuli. Values of exponents increased with longer interresponse times, indicating strong control by exteroceptive stimuli over responses following interresponse times of approximately one second or longer.

Journal Article↗
PubMed1985

Characteristics of forgetting functions in delayed matching to sample.

Performance of pigeons in delayed matching-to-sample procedures was measured in terms of an index of discriminability derived from the difference between logarithms of ratios of choice responses to comparison stimuli following the different sample stimuli. Forgetting functions that plotted discriminability as a function of delay-interval duration were well described by a simple negative exponential function with two parameters, one describing initial discriminability of sample stimuli at zero delay (log d(0)) and the other describing rate of decrement in discriminability with increasing delay-interval duration (b). With the difference between wavelength values of the comparison stimuli held constant, a large difference between wavelengths of the sample stimuli resulted in a higher log d(0) value than that for a small difference between sample stimuli, without changing the rate of decrement in discriminability, b. An increase in the fixed-ratio requirement for sample-key responding produced an increase in log d(0) without affecting b, and interpolation of ambient illumination in the delay interval increased b without influencing log d(0). Both parameters changed when intertrial-interval duration was varied. The result of variation in the point of interpolation of ambient illumination in the delay interval indicated that levels of discriminability at longer delays were independent of discriminability levels at earlier delays, consistent with the properties of the exponential function. Functions relating performance to delay-interval duration were suggested to have two characteristics: discriminability of the sample stimuli in the absence of a delay between the stimuli and the behavior they occasion, and rate of attenuation in discriminability with increasing delay-interval duration.

Journal Article↗
PubMed1985

Temporal proximity and reinforcement sensitivity in multiple schedules.

Distributions of reinforcers between two components of multiple variable-interval schedules were varied over a number of conditions. Sensitivity to reinforcement, measured by the exponent of the power function relating ratios of responses in the two components to ratios of reinforcers obtained in the components, did not differ between conditions with 15-s or 60-s component durations. The failure to demonstrate the "short-component effect," where sensitivity is high for short components, was consistent with reanalysis of previous data. With 60-s components, sensitivity to reinforcement decreased systematically with time since component alternation, and was higher in the first 15-s subinterval of the 60-s component than for the component whose total duration was 15 s. Varying component duration and sampling behavior at different times since component transition may not be equivalent ways of examining the effects of average temporal distance between components.

Journal Article↗
PubMed1984

Stimulus and reinforcer relativity in multiple schedules: Local and dimensional effects on sensitivity to reinforcement.

Pigeons' responses in two successive components of multiple schedules were reinforced according to variable-interval schedules of reinforcement that varied over five different conditions. Within each session of all conditions, line orientations of 0 degrees , 30 degrees , or 45 degrees in Component 1 alternated with orientations of 45 degrees , 60 degrees , or 90 degrees in Component 2. Response rates were recorded in three successive subintervals of each component. Ratios were taken between the response rate in each Component 1 line orientation and the response rate in each Component 2 orientation. These ratios were found to be power functions of the corresponding ratios of obtained reinforcement rates. Sensitivity of response ratios to changes in reinforcer ratios, given by the value of the exponent of the power function, increased systematically with increasing disparity between the dimensional values of orientation stimuli. In addition, sensitivity decreased systematically over successive subintervals of components, that is, with increasing time since component alternation. Dimensional and local (subinterval) effects interacted in that sensitivity increased with stimulus disparity to a far greater extent in the first subinterval than later in components. The data could be described by a combination of rectangular hyperbolae which attributed the interaction between local and dimensional effects to limits set by local effects on the extent that stimulus differences could affect sensitivity.

Journal Article↗
PubMed1983

Free-operant forgetting: Delayed stimulus control of multiple-schedule performance.

Pigeons' responses were reinforced in two components of several multiple variable-interval variable-interval schedules of food reinforcement. In one component, the key was illuminated green for 15 seconds and white for 45 seconds. In the other component, the key was illuminated red for 15 seconds and white for 45 seconds. Values for the exponent of the power functions relating response ratios to reinforcement ratios were higher in the presence of the discriminative stimuli (green or red) than in the presence of white. Sensitivity of response ratios to changes in reinforcement ratios provided an index of the extent to which responding was under delayed stimulus control by prior discriminative stimuli.

Journal Article↗
PubMed1983

Temporal constraint on choice: Sensitivity and bias in multiple schedules.

In multiple schedules of reinforcement, ratios of responses in successive components are relatively insensitive to ratios of obtained reinforcers. An analysis is proposed that attributes changes in absolute response rates to concurrent interactions between programmed reinforcement and extraneous reinforcement in other components. The analysis predicts that ratios of responses in successive components vary with reinforcer ratios, qualified by a term describing the reinforcement context, that is, programmed and extraneous reinforcers. Two main predictions from the analysis were confirmed in an experiment in which pigeons' responses were reinforced in the components of a multiple schedule and analog extraneous reinforcement was scheduled for an alternative response in each component. Sensitivity of response and time ratios to reinforcer ratios in the multiple schedules varied as a function of the rate of extraneous reinforcers. Bias towards responding in one component of the multiple schedule varied as an inverse function of the ratios of extraneous reinforcer rate in the two components. The data from this and previous studies of multiple-concurrent performance were accurately predicted by our analysis and supported our contention that the allocation of behavior in multiple-schedule components depends on the relative values of concurrently-available reinforcers within each component.

Journal Article↗
PubMed1982

Changeover delay effects on topographically tagged discriminative behavior.

In a multiple variable-interval extinction schedule, pigeons' responses on an operant key were differentially reinforced in the presence of discriminative stimuli located on a signal key. Changeover delays of zero, one, two, or four seconds specified the time following a signal-key response within which an operant-key response was not reinforced. Systematic reduction of signal-key response rates with increasing changeover-delay duration indicated that signal-key responding was largely maintained by reinforcement of adventitious signal-key/operant-key response chains.

Animals↗
PubMed1982

Delayed stimulus control: recall for single and relational stimuli.

In a discrete-trial symbolic matching-to-sample procedure, pigeons' left-key responses were reinforced following presentation of one center-key sample, and right-key responses were reinforced following presentation of another. Recallability was measured by the difference between log ratios of left to right responses following each sample. In Experiment 1, samples were successively presented same or different wavelengths in the relational discrimination, or individual wavelengths in the single discrimination. The rate at which recallability decreased with increasing delay since sample presentation was the same for single and relational discriminations, but the initial level of performance differed, indicating that the relational discrimination was more difficult. In Experiment 2, recall functions for easy and difficult discriminations between individual wavelengths also differed in levels of initial performance but not in rate of decrement of recallability over time. Recall for stimuli differing in complexity may therefore reflect differences in discrimination difficulty.

Animals↗
PubMed1981

Undermatching and contrast within components of multiple schedules.

Six multiple variable-interval schedules each comprised one variable-interval sixty second component and an alternated component which was varied. Four pigeons' responses were recorded in five successive subintervals of each component. Response rate changes across subintervals revealed instances of local contrast and small local induction effects in the changed component. In the constant component, smaller local contrast and larger local induction effects obtained. Accordingly, the magnitude of behavioral contrast, defined as an inverse relation between response rate in the constant component and reinforcement rate in the changed component, did not change reliably across subintervals of the constant component. Ratios of response rates in initial subintervals were highly sensitive to reinforcement ratios. Sensitivity decreased sharply over the first two-fifths of the components and remained constant for the remainder. The results demonstrated that changes in multiple schedule sensitivity are a function of time since the alternation of successive components.

Journal Article↗
PubMed1979

Primary eye care for the pediatric patient.

The primary care needs of the pediatric patient include the measurement of norms and deviations in the newborn (neonate) and subsequently, developmental milestones. Considerations of such norms and deviations must include familial and hereditary implications, systemic conditions and general health status. Deviations from the expected norms in the newborn and during development must be evaluated by the parent (as the true primary pediatric provider) and responsible health and eye care professionals. Such evaluation should include a sensitivity and awareness of the ocular and visual status, identification of norms and deviations and appropriate courses of action.

Child↗
PubMed1978

Behavioral contrast as differential time allocation.

In Experiment I, hooded rats were exposed to multiple variable-interval schedules of reinforcement in which manipulanda and reinforcement magazines at opposite ends of the experimental chamber were associated with the different components. Time allocated to each component was measured by recording the time spent by the subject in the appropriate half of the chamber. Positive behavioral contrast was observed for the comparison between multiple variable-interval 30-second variable-interval 30-second and multiple variable-interval 30-second variable-interval 90-second conditions for both response frequency and time allocation measures, but not for mean local response rate (response frequency per time allocated to a component). In Experiment II, rats were exposed to multiple variable-time schedules in which reinforcement was response independent. Time allocated to each component was measured for two conditions, multiple variable-time 30-second variable-time 30-second and multiple variable-time 30-second variable-time 90-second. Positive behavioral contrast of time allocation was exhibited. The results indicated that time allocation was differentially sensitive to changes in reinforcement probability, and that behavioral contrast may result from the differential allocation of time to the different components of the multiple schedule.

Journal Article↗