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Biomedical subjects

K G Heiple

Publications and source records attributed to K G Heiple.

67 records · Page 4Linked to original sources
PubMedDate not supplied

The long-term fate of fresh and frozen orthotopic bone allografts in genetically defined rats.

Fresh and frozen orthotopic iliac crest bone grafts in rats were studied histologically for determination of the long-term effects of histocompatibility matching and the freezing process on orthotopic bone graft incorporation. Grafts exchanged between groups of inbred rats, syngeneic or differing with respect to major or minor histocompatibility loci, were studied histologically at 20, 30, 40, 50, and 150 days after bone transplantation. A numerical histologic scoring system was developed and used by three observers for evaluation of coded hematoxylin and eosin sections. All frozen graft groups had the same fate regardless of histocompatibility relations between donors and recipients, and all grafts were inferior to fresh syngeneic grafts. Both fresh allograft groups received similar scores and initially at 20 and 30 days had scores similar to those of the fresh syngeneic groups. In the later intervals, however, the fresh allografts were inferior to the fresh syngeneic grafts and similar to the frozen groups. This is consistent with an older model describing two distinct phases of osteogenesis. In the long term, frozen syngeneic and fresh and frozen allografts across major and minor histocompatibility barriers were comparable, but all were significantly inferior to fresh syngeneic bone grafts.

Animals↗
PubMedDate not supplied

Prognosis in septic arthritis of the hip in children.

Thirty-eight children (39 hips) with septic arthritis have been reviewed in an effort to determine the factors most important to prognosis of the hip joint. The younger patients, 3 or more years later, had poorer results by roentgenographic classification. This was particularly true of patients under one year of age. Longer duration of disease from clinical onset to initiation of therapy also resulted in a poorer result. The outcome could not be clearly correlated with the causative organism or with open as opposed to closed treatment although the policy of management was strongly biased to open drainage. Sixty per cent of the infections were caused by Staphylococcus aureaus and the majority of the other cases by Streptococcus pyogenes and Hemophilus influenzae. The nonstaphylococcal organisms may be less destructive to the femoral head in infants.

Adolescent↗