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Biomedical subjects

K Fukuta

Publications and source records attributed to K Fukuta.

At least 109 records · Page 6Linked to original sources
PubMed1987

Operative fiberoptic nephroureteroscopy: removal of upper ureteral and renal calculi.

We tested 2 prototypes of an operating fiberoptic nephroureteroscope, measuring 3.5 and 4.5 mm. in diameter, that have an adequate working channel for auxiliary instruments and irrigation. Difficulty in passing the fiberscope through the ureteral orifice was overcome by dilation with balloon and polytetrafluoroethylene (Teflon) dilators. Our initial trial for stone retrieval under fiberscopic control was performed on 21 patients with upper ureteral and renal calculi. A stone was removed successfully in 15 of the 21 patients (71 per cent). After electrohydraulic lithotripsy calculi were extracted successfully in 9 of 11 patients (82 per cent). Three patients suffered ureteral perforation. The fiberscope was especially helpful when an upper ureteral stone moved back to the kidney during stone manipulation.

Adult↗
PubMed1987

[Clinical trials of flomoxef in complicated urinary tract infections].

Flomoxef (6315-S, FMOX), a new oxacephem antibiotic was studied clinically in 27 patients with complicated urinary tract infections. FMOX was intravenously administered at a dose of 1.0 g twice daily for 5 days. Clinical effect of FMOX on patients with complicated urinary tract infections were excellent in 11.5%, moderate in 57.7% and overall clinical efficacy rate was 69.2%. During the treatment with FMOX, urticaria was observed in 1 case. In laboratory tests, a decrease of RBC, Hb and Ht in 1 case, a decrease of WBC in 1 case and an elevation of GPT in another case were observed. But these abnormal values were slight and transient.

Adult↗
PubMed1987

Application of the fluorometric DNA quantitative assay using 4'6-diamidine-2-phenylindole for the evaluation of lymphocyte blastogenic response.

A fluorometric DNA microassay using the fluorescent reagent 4'6-diamidine-2-phenylindole dihydrochloride (DAPI) was developed for evaluating a lymphocyte DNA synthesis assay. Triton X-100 (0.05 per cent) was added to the cultured lymphocytes, then DAPI (0.8 micrograms ml-1) was added as a DNA-specific fluorescent intercalating agent. Results are expressed as fluorescence intensity (FI) and stimulation index. FIs measured by DAPI fluorometric assay were highly correlated with [3H]-thymidine incorporation (r = 0.868, P less than 0.01, n = 28). The method is simple, reliable and widely applicable for evaluating blastogenic responses.

Animals↗
PubMed1987

[Operative fiberoptic nephroureteroscope--removal of renal and upper ureteral stones].

Two types of operative fiberoptic nephroureteroscopes were developed with the cooperation of the Olympus Optical Company mainly to remove the upper urinary tract calculi. Removal of the renal and upper ureteral stones was attempted in nine cases. The ureter was dilated with olive tip, balloon and Teflon dilators alone or in combination. The combination of balloon and Teflon dilators seemed the most promising. As a result of ureteral dilation, operative fiberoptic nephroureteroscopes, 4.5 mm and 3.5 mm in diameter, could be passed into the ureter in all the cases and the stones could be visualized clearly. Four of the 7 upper ureteral stones and 1 of the 2 pelvic stones could be removed. The success ratio was 56%. The method of stone removal still requires improvement. At present, application of the operative fiberoptic nephroureteroscope is indicated for upper ureteral and renal stones less than 1.0 cm in diameter. With the improved techniques of stone removal using this fiberscope, the indications of extracorporeal shock-wave lithotripsy or percutaneous nephrolithotripsy will probably be greatly reduced in the near future.

Adult↗
PubMed1986

[Randomized study of cisplatin and doxorubicin with or without vincristine in non-small cell lung cancer].

A randomized study of anticancer chemotherapy, CDDP plus ADM with/without VCR on patients with NSCLC was carried out. Forty-six patients received injections of CDDP (75 mg/m2) and ADM (50 mg/m2) every 4 weeks (Regimen A); 39 patients were injected with the same doses of CDDP and ADM, plus VCR (1.4 mg/m2, on day 1 and 0.7 mg/m2, on day 7), every 4 weeks (Regimen B). Seven patients (15%) and 10 patients (26%) achieved a partial response by Regimens A and B, respectively. The median survival time (MST) was 8.5 months in each group. Survival time of the responders (MST; 27 months) was much more prolonged than that of the non-responders (MST; 7 months) (p less than 0.01). Both regimens were well tolerated with only moderate gastrointestinal symptoms and mild bone marrow toxicities. Although the addition of VCR to CDDP plus ADR in NSCLC fulfilled the objective tumor regression, no additive effect could be obtained with regard to survival.

Adenocarcinoma↗
PubMed1982

Formation of reticular fibers in the developing spleen of the chick embryo.

An electron microscope study was made to elucidate the manner in which reticular fibers form in the developing spleen of the chick embryo. On the 7th day of incubation, the splenic reticulum consisted of dendritic reticular cells without reticular fibers. From the 9th day onward, the intercellular gaps between processes of adjacent reticular cells were expanded, becoming occupied by fine flocculent materials. With the growth of the embryos, these materials were aggregated into felt-like bands, exhibiting the characteristics of mature reticular fibers. In the interstices of the reticulum, there appeared microfibrils of 8-30 nm in diameter. The reticular cells possessed numerous free ribosomes and polysomes, well-developed Golgi apparatuses, dilated rough-surfaced endoplasmic reticula, and many coated vesicles. The coated vesicles contained fine flocculent materials as presumable fiber precursors. The vesicles were enlarged as they approached the cell periphery, where they appeared to discharge their contents by reverse pinocytosis. some vesicles close to the cell membrane contained ruthenium red-positive materials which were considered to be glycosaminoglycan in nature and to compose the matrix of fibers. These materials also seemed to be secreted by reverse pinocytosis, being densely accumulated in the intercellular gaps. The differentiation of fibrous proteins into felt-like reticular fibers or striated microfibrils seems, therefore, to be intimately associated with the amount of glycosaminoglycan.

Animals↗
PubMed1982

Light and electron microscopic observations of the spleen in the musk shrew, Suncus murinus.

In the spleen of the musk shrew, a marginal zone was clearly demonstrable between the white pulp and the red pulp. The white pulp was separated from the marginal zone by a septum, a circumferential layer of reticular cells and fibres, and between the marginal zone and red pulp there was a population difference of blood cells. The white pulp consisted of periarterial lymphatic sheaths and lymphoid follicles including germinal centres. The marginal zone was filled by numerous erythrocytes, some lymphocytes, granulocytes and a few macrophages, while the red pulp had a large number of neutrophils, eosinophils, megakaryocytes and their precursors. In the red pulp erythroblasts tended to form islets, and there were a few basophils, plasma cells, plasmablasts and macrophages. Haematopoiesis was also active in the bone marrow.

Animals↗
PubMed1980

Primary formation of germinal centers in the chick spleen after injection with sheep red blood cells.

The primary formation of germinal centers was induced in the chick spleen by intravenous injection of sheep red blood cells (SRBC) at 21 days of age. In the spleen, SRBC were trapped in the ellipsoids soon after injection. The number of cells of periellipsoidal lymphoid tissues (PELT) was gradually depleted. Large pyroninophilic cells appeared in the periphery of periarterial lymphatic sheaths (PALS) 4 hrs after injection. Then they increased in number and migrated centralward in the PALS. On the 4th day they were accumulated in the vicinity of the central arteries to make nodular structures. Morphologically mature germinal centers encapsulated by connective tissue were formed for the first time on the 6th day after injection. They were most numerous on the 8th day and then decreased gradually. It was presumed that the primary germinal centers in the chick spleen might have been formed by the cells of the PELT which were originally derived from the bursa of Fabricius. The process of proliferation of germinal centers in the secondary immune response was discussed.

Animals↗
PubMedDate not supplied

Recent advances in medical imaging: surgery planning and simulation.

Three-dimensional display of medical image data has under gone rapid development since its introduction. This article explores the current state-of-the-art of 3-dimensional imaging applied to surgery planning and discusses the various image acquisition sources: computed tomography (CT), cine CT, magnetic resonance imaging, and ultrasound. Since increased physician involvement is the goal of the surgery planning software described, the future directions discussed emphasize the inclusion of "expert" knowledge and ways to facilitate realistic interaction for surgery simulation.

Computer Simulation↗
PubMedDate not supplied

The volume limitation of the galeal temporalis flap in facial augmentation.

Galeal temporalis flaps based on the superficial temporal vessels have been used for facial augmentation and can be extended to the contralateral side beyond the midline in order to achieve maximum volume. In five patients, the volumes of extended galeal flaps were measured intraoperatively using a water displacement method. The calculated volume varied between 28 and 38 cm3. Experience with this flap showed satisfactory results with no complications; therefore, it is concluded that the extended galeal temporalis flap may be a first choice in the correction of facial soft tissue deficits less than 40 cm3. Clinical cases are presented.

Adult↗
PubMedDate not supplied

Anatomical and histological characterization of the female reproductive organs of mouse deer (Tragulidae).

The Tragulidae may be a type that represents the earliest ruminant families to evolve. The female reproductive organs including ovary, oviduct, uterus and placenta were anatomically and histologically investigated. The structures of the ovary and oviduct were very similar to other ruminants. However, the gross structure of the placenta was diffuse and thus noticeably different from other ruminants which are polycotyledonary. Histologically, the placenta of Tragulidae appears to be epitheliochorial and therefore similar to other ruminants. Numerous trophoblastic binucleated cells which are characteristic of all other ruminants were observed. These results suggest that the placenta of Tragulidae is a transitional type between diffuse epitheliochorial and polycotyledonary synepitheliochorial categories.

Animals↗
PubMedDate not supplied

Isotricha jalaludinii n. sp. found from the rumen of lesser mouse deer, Tragulus javanicus, in Malaysia.

Isotricha jalaludinii n. sp. found in the rumen of lesser mouse deer, Tragulus javanicus, in Malaysia was described and illustrated. This new species is characterized by the location and direction of the vestibulum, shape of the macronucleus, and absence of a dent at the vestibular opening. The presence of single peculiar isotrichid species in the rumen of mouse deer, which is recognized as one of the most primitive ruminants, suggests that the isotrichid ciliates similar to I. jalaludinii and Isotricha intestinalis were established at a fairly early period during the evolution of ruminants.

Animals↗