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Biomedical subjects

K Fujimoto

Publications and source records attributed to K Fujimoto.

At least 883 records · Page 49Linked to original sources
PubMed1982

Prothracarcin, a novel antitumor antibiotic.

A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. raffinophilus DO-62. The antibiotic has the molecular formula of C14H14N2O and belongs to the pyrrolo [1,4]benzodiazepine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine tumor sarcoma 180 and leukemia P388.

Animals↗
PubMed1982

Age-related immunoglobulin levels in cynomolgus monkeys.

Serum immunoglobulin levels were measured with 144 domestically-bred cynomolgus monkeys, aged 0 day to 18 years. IgG level of the newborn just after birth was somewhat lower than that of their mother monkeys, continuing to decrease for 3 postnatal months. Thereafter, the level began to increase gradually till 4 to 5 years when an adult level was attained. IgA was detected on the day of birth in half of the animals and started to increase soon after birth, reaching an adult level in 5 to 6 years. A relatively low level of IgM was detected in all animals at birth. The increase of IgM level continued till 5 years of age. These patterns of immunoglobulin levels related to age are very similar to those of rhesus monkeys and human.

Age Factors↗
PubMed1982

Changes in serum immunoreactive pancreatic elastase 1 in acute pancreatitis.

Serum immunoreactive elastase 1 content was significantly elevated in acute pancreatitis. The mean content of the control group was 1.79 ng/ml (SD: 0.62 ng/ml), while that of patients with acute pancreatitis was 23.02 ng/ml (SD: 9.44 ng/ml). The increased content of pancreatic elastase 1 in acute pancreatitis continued for several days after onset, even though serum amylase activity had returned to normal.

Acute Disease↗
PubMed1981

Adrenergic mechanisms in the hyperglycaemia and hyperinsulinaemia of diabetic KK mice.

Simultaneous occurrence of hyperglycaemia (up to 300 mg/100 ml) and hyperinsulinaemia (up to 1200 mu U/ml) was evident in the fed state in genetically diabetic KK mice, indicating insulin resistance. The hyperinsulinaemia was enhanced by alpha-adrenergic blockade and alleviated by B-blockade. Epinephrine-induced hyperglycaemia and isoproterenol-induced hyperinsulinaemia, both of which could be blocked by beta-adrenergic antagonists, were more marked in KK mice than in ICR mice. A possible significance of adrenergic mechanisms is discussed with respect to the aetiology of the metabolic disturbances characteristic of KK mice.

Animals↗
PubMed1981

Turnover rate of blood glucose in diabetic KK mice.

Metabolic rate constants for blood glucose turnover were estimated based on the decay of [U-14C, 6-3H]glucose injected intravenously in genetically diabetic KK mice. Comparison was made with the rate constants similarly obtained with non-diabetic and streptozotocin-induced diabetic ICR mice. Recycling of blood glucose via the Cori cycle, as estimated from the difference in the decay rate between 14C and 3H, was more active in KK mice than in non-diabetic and diabetic ICR mice. The Cori cycle activity was reduced by beta-adrenergic blockade in KK mice and was enhanced by alpha-blockade in ICR mice. It is concluded that predominance of beta-adrenergic functions in KK mice is responsible for activation of the Cori cycle as one of the mechanisms for metabolic resistance to endogenous insulin.

Animals↗
PubMed1981

Detection of ABO group-specific substances on the red cells of the cynomolgus monkey.

Several attempts were made to demonstrate the presence of ABO blood group substances on the red blood cells (RBC) of the cynomolgus monkey. Neither the direct hemagglutination test nor the antibody absorption test was successful in detecting these substances from whole RBC, the stromata or the butanol extracts of RBC. By the heat elution of antibodies, however, the presence of ABH substances was demonstrated on RBC of every phenotype without fail. In all cases, there was a reciprocal relationship between the ABH substances of RBC and of saliva and the anti-A and anti-B antibodies in serum, being in good agreement with Landsteiner's rule. Accordingly, it can be concluded that a small amount of ABH substances must be present on RBC of the cynomolgus monkey.

ABO Blood-Group System↗