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Biomedical subjects

K Francis

Publications and source records attributed to K Francis.

68 records · Page 4Linked to original sources
PubMed1984

The use of the microcomputer in fitness assessment and exercise prescription for the older adult.

The process outlined in this paper points to the fact that fitness assessment and exercise prescription is largely an information management task. The gap between existing knowledge and its practical application to the care of patients can be successfully closed by using modern information services. For health professionals, moving into the computer age will be an evolutionary, continuing education process. For clinical practice to reach its full potential, there must be an improvement in methods of handling information. The microcomputer offers an innovative way of providing the clinician with a practical, inexpensive manner of information management that will lead to improved efficiency, safety, and lower health care cost and at the same time provide patient satisfaction. Microcomputer applications in fitness assessment, dietary analysis and exercise prescription for the elderly are presented.

Aged↗
PubMed1980

Studies on osteoporosis IV. Effect of benzo[b]thiophene-2- and dibenzothiophene-4-carboxylic acid on heparin accelerated osteoporosis.

Total skeletal calcium was determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heaprin produced significant osteoporosis in C3-H/St(Ha) mice but not in C57/BL6(J) mice. This was more pronounced in the younger (5-8 months) than in the older (15-18 months) animals. Two 2-thiophene carboxylic acid derivatives showed significant osteoporosis preventive activity.

Animals↗
PubMed1979

Photosynthesis by isolated chloroplasts of Sorghum vulgare.

The ambiguous location of photosynthetic carboxylases of mesophyll and bundle sheath chloroplasts of sorghum was investigated after successful homogeneous preparation. The phosphoenol pyruvate carboxylase was found as a particulate enzyme in the mesophyll cell chloroplasts and ribulose 1,5-biphosphate carboxylase in the stroma of the bundle sheath cell chloroplasts. Extensive characterization was carried out on these 2 enzymes for better understanding of the enzyme action.

Carbon Dioxide↗
PubMedDate not supplied

The possible prognostic significance of immunophenotype in feline alimentary lymphoma: a pilot study.

Twenty-three retrospective biopsy specimens from feline intra-abdominal lymphomas including tumours affecting the gastrointestinal tract, mesenteric lymph nodes, liver and spleen were immunohistochemically labelled with monoclonal antibodies to CD79a (B-cell phenotype) and CD3 (T-cell phenotype). Positive labelling occurred in 15 (65%) and 6 (26%) of the tumours, respectively. No statistically significant relationship was found between tumour cell immunophenotype and age, breed, or gender. There was no significant difference in survival time between the two immunophenotypes, based on the 16 cats for which this information was available.

Animals↗
PubMedDate not supplied

Preparation and characterization of liposomes containing a lipophilic cisplatin derivative for clinical use.

Cis-bis-neodecanoato-trans-R,R-1,2 diaminocyclohexane platinum(II) (NDDP) is a lipophilic cisplatin derivative that has been formulated entrapped in multilamellar liposomes composed of dimyristoylphosphatidyl choline (DMPC) and dimyristoylphosphatidyl glycerol (DMPG). A phase I clinical study with liposome-entrapped NDDP (L-NDDP) administered i.v. every 4 weeks has been recently completed. L-NDDP was synthesized, manufactured, and reconstituted for clinical use in our laboratories. L-NDDP was prepared as a lyophilized powder containing the NDDP and the phospholipids (NDDP-lipid weight ratio 1:15; DMPC-DMPG molar ratio 7:3). The liposome suspension was obtained on the day of use just before administration to the patients by adding normal saline (final concentration 1 mg NDDP/ml) and shaking in a water-bath shaker at room temperature according to an established protocol. A total of 54 batches of lyophilized L-NDDP were prepared. Physical appearance, phospholipid content and integrity, and elemental platinum content were determined in all batches and found to be reproducible. All batches contained < 0.24 ng/ml endotoxin. The amount of residual organic solvents was < 0.05 per cent. In all reconstituted doses, drug entrapment was > 90 per cent, and the proportion of liposomes measuring > 5 microns was < 20 per cent. Our results show that reproducible batches of liposomal preparations of new compounds can be prepared in the laboratory facilities of academic institutions, thus allowing for early clinical trials with novel therapeutic agents.

Antineoplastic Agents↗