Absence of human herpesvirus 8 DNA sequences in patients with immunosuppression-associated dermatofibromas.
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DNA, Viral↗
Biomedical subjects
K Foreman
Publications and source records attributed to K Foreman.
Effect of dialyzer reprocessing with Renalin on serum beta-2-microglobulin and complement activation in hemodialysis patients.
The peracetic acid-based sterilant Renalin is increasingly being used for reprocessing hemodialyzers. In order to evaluate the effects of reprocessing on beta 2-microglobulin (beta 2M) kinetics and complement activation in chronic hemodialysis patients, we compared 4 dialyzer membranes on 1st, 2nd and 4th use of the membrane. Dialysis with new cuprammonium rayon dialyzers (0.8 m2) for 4 h resulted in a nonsignificant increase in serum beta 2M concentrations of 10.7% (corrected for changes in extracellular volume) and significant generation of the complement component C3a des Arg. On reuse, minimal changes in serum beta 2M levels were noted and complement activation was absent. Dialysis with new cellulose acetate (CA, 1.5 m2), polyacrylonitrile (AN69 HF, 1.6 m2) or polymethylmethacrylate (PMMA, 1.6 m2) membranes resulted in significant decreases in serum beta 2M levels (19.5, 31.7 and 50.8%, respectively). Reprocessing had negligible effects on the removal of beta 2M by CA and AN69, but by the 4th use halved the effectiveness of PMMA. Reprocessing reduced the significant generation of C3a des Arg observed with new CA and PMMA membranes. We conclude that, except for PMMA, Renalin reprocessing has minor effects on the ability of the membranes to remove beta 2M and improves the biocompatibility of all membranes studied.
Acetic Acid↗
Dialyser reprocessing with Renalin.
We evaluated the dialyser reprocessing agent Renalin in a 6-month prospective study of 2,759 dialyses on 59 patients. Dialysers were withdrawn after a maximum of 6 uses, and the average number of uses achieved was 4.5 Dialyser survival varied with the type of dialyser but was unaffected by the dialysate base. In vivo clearances of urea, creatinine and phosphate were not altered by reuse, but there was a small decrease in ultrafiltration characteristics of used dialysers. No clinically significant adverse event was attributed to reuse. Blood pressure was better preserved with used dialysers, and patients experienced significantly fewer intradialytic symptoms. Savings of over +A 25,000 were achieved during the study.
Acetates↗
Comparison of six different regimens for the control of atrophic rhinitis in swine.
Effectiveness of six different programs of atrophic rhinitis (AR) control was evaluated under field conditions. Efficacy of treatments was recognized on the basis of--comparative evaluation of the average daily gain (ADG), morphometric examination of turbinate bones and computer conchal morphometry (TPR). Usefulness of the evaluated regimes differed significantly. TPR appeared to be the most objective method for AR evaluation. Correlation between severity of turbinate atrophy and ADG was only partial.
Animals↗
Human toxocariasis in a rural community.
A questionnaire and serologic survey of a Pennsylvania community revealed that 23 (54%) of 43 study participants had antibody titers to Toxocara canis (enzyme-linked immunosorbent assay test [ELISA]) in the range defined as positive (greater than or equal to 1:32). Age-specific seropositivity rates were highest among adults (greater than or equal to 18 years). Positive titers ranged from 1:32 to 1:512. Seropositivity did not cluster by family, and seropositivity rates were significantly higher than those of a control group. Physical examination and laboratory tests designed to detect clinical signs of toxocariasis were performed on individuals with positive ELISA titers. Nine of 23 had a history of pica, seizures, or chronic pulmonary symptoms; however, physical examination revealed no abnormalities. Although medical examination and laboratory tests revealed a few abnormalities, neither the visceral larva migrans syndrome nor the ocular lesions characteristic of those produced by Toxocara sp were observed in any individual. We conclude that although certain populations may have high seropositivity rates to Toxocara antigens, indicating previous infection, clinical diseases may be uncommon.
Adolescent↗
Creating the right environment for return-to-practice candidates.
With a recognised national shortage of qualified nurses in England, a trust and university joined forces to provide a return-to-nursing course (ENB 902). This article describes how they provided clinical support and encouraged nurses to return to practice.
Adult↗