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Biomedical subjects

K Fleischer

Publications and source records attributed to K Fleischer.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Dose-response relation of gallopamil in comparison with nifedipine, diltiazem and tiapamil in patients with coronary heart disease].

For effective treatment of coronary heart disease with calcium antagonists, knowledge of both the dose-response relationship of a remedy and equipotent dosage for comparison of different drugs is necessary. We performed controlled studies to evaluate the influence of single oral doses of calcium antagonists on ischemic ST-depression (calculated as the mean of all exercise and recovery minutes = mean ST-depression) in exercise ECGs of patients with proven CHD and stable angina pectoris. Ergometries were carried out under constant conditions, particularly with individually constant work load and duration. All calcium antagonists reduced ischemic ST-depression during ergometry dose-dependent when compared to placebo. Diltiazem: 90 mg: 6% (n.s.), 120 mg: 19% (n.s.) und 180 mg: 26% (p less than 0.025); gallopamil: 25 mg: 19% (n.s.), 50 mg: 34% (p less than 0.01) und 100 mg: 57% (p less than 0.0025); nifedipine-Cps.: 5 mg: 17%, 10 mg: 33% und 20 mg: 42%; nifedipine-Tbl.: 20 mg: 8% (p less than 0.05), 40 mg: 23% (p less than 0.057 und 60 mg: 31% (p less than 0.05); tiapamil: 300 mg: 30% (p less than 0.05) und 600 mg: 60% (p less than 0.01). As the result of our findings, comparable antiischemic effects can be expected with 120 mg diltiazem, 50 mg gallopamil, 20 mg nifedipin as capsule or 60 mg nifedipin as tablet and 600 mg tiapamil.

Adult↗
PubMed1987

[Cutaneous diphtheria from Africa].

A 31-year-old woman returned to her native Germany, after a two-year stay in Tanzania, suffering from cutaneous diphtheria which had spread to nose and throat. One of her three children, a four-year-old boy, also had Corynebacterium diphtheria in his throat, without any symptoms. Both mother and child had been immunized against diphtheria.

Adult↗
PubMed1987

[Hearing damage following meningitis then and now].

Audiometric examination of children who have suffered a bacterial meningitis show that in about a quarter of them a moderate to severe, often unilateral, hearing loss is to be expected despite antibiotic treatment. Hearing loss is more frequent in cases of severe meningitis and appears to depend upon the time of treatment. The most feared infection is that due to Hemophilus influenzae. No hearing damage was encountered in meningitis due to virus, in confirmed mumps infection or when the CSF was free of bacteria.

Adolescent↗
PubMed1983

[Disease manifestations in the otorhinolaryngologic region as the sequelae to side effects of drugs].

The side effects of numerous drugs may lead to pathological changes or functional disturbances in the ENT region. In order to explain the causes of presenting symptoms, the ENT doctor should always take in consideration the various drugs which the patient is receiving but which have been prescribed by other specialists. This is pertinent particularly in pathological changes of the oral mucosa, impairment of salivary secretion, hearing, smell and taste as well as disturbances of tubal function and voice changes. The causative drugs and their mode action are discussed.

Drug Hypersensitivity↗
PubMed1982

[Unusual traumatic alterations of the tongue (author's transl)].

A baby with congenital sensoric neuropathy showed, due to missing sensitivity to pain, repeated injury of the tongue resulting from bites after the front teeth had erupted. The defect formed at the tip of the tongue and showed excessive granulation resembling at first sight a tumorous process. Such alterations of the tongue usually are the first symptom of this rare disease and therefore are most important for diagnosis. With another infant presenting with Joubert's syndrome, i.e. cerebellar malformation, macroglossy, increased motility of the tongue and severe dyspnoic attacks combined with seizures, also tumorous granulomatous alterations of the tongue were found, due to chronic injury of the tongue by bites.

Child, Preschool↗
PubMed1982

[Pneumatosis cystoides intestinalis in dolicho-sigmoid colon with functional signs].

We present a patient with dolicho sigmoid colon who as admitted with severe functional signs and symptoms. Sigmoid colectomy was performed because of additional radiologic and endoscopic findings revealing an atypical, circumscribed massive polyposis. On histological examination typical pneumatosis cystoides intestinalis was found. This case of pneumatosis cystoides reveals the difficulties in diagnosing this disease, mechanically induced mucosul lesions caused by impaired motility are discussed as a possible etiology in this case.

Colon, Sigmoid↗
PubMed1980

[The diagnostic problem of Wegener's granulomatosis (author's transl)].

Histological findings of granulomatous vasculitis can frequently be absent in attempting to diagnose early nasal manifestations of Wegener's granulomatosis. In such cases, one has to rely on clinical findings and laboratory data (particularly an excessively high blood sedimentation rate). The possibility for misdiagnosis is illustrated in four patients who all appeared to have Wegener's granulomatosis. Followup over many months revealed that the diagnosis was correct in only two of the patients, indicating also the problems associated with inappropriate treatment.

Adult↗