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Biomedical subjects

K F King

Publications and source records attributed to K F King.

11 recordsLinked to original sources

Optimized gradient waveforms for spiral scanning.

Spiral scanning gradient waveforms can be optimized with respect to blurring from off-resonance effects by minimizing the readout time. This is achieved by maximizing the gradient amplitude during the scan so that the edge of k-space is reached as quickly as possible. Gradient hardware constraints are incorporated by considering a circuit model for the gradient coil and amplifier. The optimized gradient waveforms are determined by a set of coupled differential equations. The resulting solutions have shorter readout time than solutions that do not consider the circuit model.

Acceleration

Closed intramedullary nailing of femoral shaft fractures. A review of one hundred and twelve cases treated by the Küntscher technique.

Since May 1972, the standard treatment of femoral shaft fractures at the Western General Hospital has been the closed femoral nailing technique of Küntscher. We have found that the use of intraoperative skeletal traction eliminates the need for immediate operation, preoperative skeletal traction, or the use of a distraction apparatus to prevent preoperative shortening. By the use of a cross-pinning technique, the closed femoral nailing method has been extended to include severely comminuted fractures of the femoral shaft and fractures of the distal third of the femur, with effective control of shortening and rotatory deformity. This allows early mobilization and discharge from the hospital for patients with these difficult fractures. One hundred and twelve consecutive traumatic fractures of the femoral shaft treated in this manner united within three to six months. The clinical results in terms of early joint movement, early weight-bearing, and rapid discharge from the hospital have been excellent.

Bone Nails

A recent development in the treatment of severe compound fractures.

The Wagner leg lengthening device has recently been used successfully as an external fixation device in the stabilization of severe compound fractures. Fixation is rigid, yet adjustable, it does not interfere with the fracture site, and it allows clear access to wounds.

Fracture Fixation

Back injury.

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Back Pain

Periosteal pedicle grafting in dogs.

An experimental model was designed to find a theoretical solution to the clinical problem of congenital tibial pseudarthrosis in children. The osteogenic properties of periosteum having been accepted, paired pedicled flaps of periosteum were raised from the subcutaneous surface of the tibia, tubed and anastomosed in a series of young dogs. In the last twenty-four consecutive cases the rate of complete ossification in these tubes rose to one in three. In the later stages of the work, in addition to the construction of periosteal tube grafts, pseudarthroses were induced in the middle third of each canine tibia in order to see if hypertrophy would occur under the stress of weight-bearing. It was found that in each of twenty-four specimens some hypertrophy occurred in the ossified periosteal tube grafts, and in three of the specimens this hypertrophy was associated with complete ossification of the graft that by-passed the pseudarthrosis.

Animals

Controlled drug release from polymeric delivery devices. III: In vitro-in vivo correlation for intravaginal release of ethynodiol diacetate from silicone devices in rabbits.

Forty female rabbits were implanted with silicone vaginal devices containing ethynodiol diacetate for up to 8 weeks. As predicted from in vitro studies, a Q - t1/2 (matrix-controlled) release profile was observed in vivo. The in vivo drug release profile was compared with in vitro data measured at three hydrodynamic conditions, and the diffusional resistance across the vaginal wall was estimated. Drug released from silicone devices yielded a prolonged plasma level when compared with data following intravaginal or intravenous administration of a solution dose. The rate constant for elimination was unchanged. The plasma concentration of the drug was related to the intravaginal drug release profile both theoretically and experimentally and was above the concentration required to inhibit fertilization.

Animals

A unified description of NMR imaging, data-collection strategies, and reconstruction.

In nuclear magnetic resonance (NMR) imaging by the zeugmatographic methods, there is a common and unified theoretical description. All forms of two-dimensional and three-dimensional imaging involve NMR data which trace various geometric representations, in reciprocal transform space, of the subject's spatially blurred "effective" spin density. The effective density is proportional to the physical density modulated spatially by the several factors of receiver coil (B/I) ratio, rf pulse excitation terms, T1-relaxation terms, and T2-relaxation terms. These factors depend upon the rf pulse sequence and field-gradient modulation sequence,and they may be calculated according to some model or directly measured. From this viewpoint, all different imaging modes appear as variations in data-collection and image-reconstruction strategies. The results are used here to describe slice-oriented polar and Cartesian strategies, three-dimensional Cartesian and two forms of spherical strategies, and multiecho strategies of the "planar-echo" type.

Image Enhancement

Computed tomography scanning with simultaneous patient translation.

This paper deals with methods of reducing the total time required to acquire the projection data for a set of contiguous computed tomography (CT) images. Normally during the acquisition of a set of slices, the patient is held stationary during data collection and translated to the next axial location during an interscan delay. We demonstrate using computer simulations and scans of volunteers on a modified scanner how acceptable image quality is achieved if the patient translation time is overlapped with data acquisition. If the concurrent patient translation is ignored, structured artifacts significantly degrade resulting reconstructions. We present a number of weighting schemes for use with the conventional convolution/backprojection algorithm to reduce the structured artifacts through the use of projection modulation using the data from individual and multiple slices. We compare the methods with respect to structured artifacts, noise, resolution and to patient motion. Review of preliminary results by a panel of radiologists indicates that the residual image degradation is tolerable for selected applications when it is critical to acquire more slices in a patient breathing cycle than is possible with conventional scanning.

Algorithms