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Biomedical subjects

K Eyrich

Publications and source records attributed to K Eyrich.

At least 55 records · Page 3Linked to original sources
PubMed1985

The effect of dopamine on muscle PO2 in healthy volunteers and intensive care patients.

The effect of systemic dopamine administration (2-10 micrograms kg-1 min-1) on the Po2 distribution (histograms) and the mean Po2 in the m. vastus lateralis of m. quadriceps femoris in nine healthy volunteers and seven critically ill patients has been studied with a newly developed bedside measuring procedure. Dopamine initially raised mean muscular Po2 in both groups. In the volunteers, mean muscular Po2 thereafter decreased gradually but still remained slightly elevated after 30 min of dopamine infusion. This increase in muscle oxygenation could be abolished by the administration of a dopamine antagonist (metoclopramide). In the patients, the initial dopamine-induced increase of Po2 was significantly slower and reached a plateau within 30 min. The results are discussed with special attention given to the data available on the action of dopamine on given peripheral circulation.

Critical Care↗
PubMed1984

[Fatal burn from a heated mat on the operating table].

A number of heating mats were developed for use on operating tables in order to avoid hypothermia and incidental cardiocirculatory changes in patients undergoing prolonged surgical interventions. Because of inadequate technical safety devices, they can cause burns in patients. We report the case of a patient who, undergoing surgery for an aortobifemoral bypass, died of 2nd and 3rd degree burns after having been placed on a Maquet mat. Other possibilities which may lead to such severe burns are discussed.

Aged↗
PubMed1983

[Respiratory and sleep-inducing effects of i.m. midazolam as premedication for regional anesthesia. Comparison with diazepam, promethazine/pethidine and placebo].

The effects of respiratory depression and sleep induction produced by 0.1 mg/kg and 0.15 mg/kg of midazolam i.m. were examined in patients in whom urological interventions had to be performed under spinal anesthesia. The same parameters were evaluated for 0.2 mg/kg of diazepam i.m. as well as 50 mg/50 mg of pethidine/promethazine i.m. and placebo i.m. The major difference between 0.1 mg and 0.15 mg/kg body weight of midazolam was a more pronounced PCO2-increase in the group with the higher dosage. Both dosages led to anterograde amnesia in 8 or 9 of 10 patients respectively. No amnesia developed in the control groups. Respiratory depression and sleep induction occurred later with promethazine/pethidine (at 60 min) or diazepam (at 120 min) than with midazolam. Noteworthy in the Diazepam and placebo group was a hyperventilation lasting 60 and 120 min respectively. The arterial PO2 decreased in all groups during the intervention. Under midazolam, the decrease was significantly higher statistically than in the control groups during the first 60 min at both dosages. Premedication with 0.1 mg/kg i.m. of midazolam proved to be sufficient in all patients. The rapid onset of action, the sleep during the intervention and the amnesia associated with it suggest that this form of premedication is more favorable than the other procedures examined. The dosage of 0.15 mg/kg of midazolam proved to be too high: in addition to producing a stronger respiratory depression, it had the effect of rendering cooperation with some patients more difficult.

Aged↗
PubMed1978

[Clinical aspects of massive transfusions].

Clinical aspects of massive transfusion (a minimum of 51 blood/6 hours) were investigated in 30 surgical and urological patients. Main bleeding causes were large tumors, liver surgery, prostatectomy and vascular surgery. Two thirds of the patients died, half of them from irreversible hemorrhagical shock. In secondary causes of death were clotting disturbances, renal failure and infections. About 50% of the transfused patients developed hyperbilirubinemia and hypokalemia. The aim of therapy in massively bleeding patients should be a sufficient continuous substitution of blood volume, heated and filtrated blood, heparinisation and balanced substitution of clotting factors.

Accidents, Traffic↗