Biomedical subjects
Publications and source records attributed to K Eriksen.
1. The effect of the adrenergic blockers prazosin and atenolol were tested in hypercholesterolemic Göttingen minipigs. 2. After 1 yr there was a significant reduction of plasma triglycerides and total cholesterol in the medicated animals as compared to untreated ones. 3. No significant difference in atherosclerotic lesions was observed.
Explore the source record for details and available documents.
The influence of prazosin and propranolol on serum lipids and atherosclerosis was evaluated in standard fed pigs during a nine months experimental period. The incidence and severity of atherosclerotic lesions was very low, and no difference could be observed neither between the two drugs nor between the drug groups and the placebo group. Prazosin and propranolol induced no marked change in the serum lipid profile. The results could be explained by the very low fat content, 3.6 per cent, in the present standard diet.
Explore the source record for details and available documents.
In an uncontrolled investigation 63 selected patients with verrucae vulgares were sensitized with DNCB (1-chloro-2,4-dinitrobenzene) with subsequent regular painting of the warts with DNCB. Only 86% of these patients could be sensitized, in contrast to 96% in a normal population. 20 patients had to be excluded from the material on account of defaulting or defective sensitization. In the remainder of the patients allergic type IV inflammation developed around the painted warts and 1 patient developed an urticarial type I reaction around the warts and on the body. In the patients with multiple warts, 80% (24/30) were cured. This corresponds to the percentage cure in patients with solitary warts. Complement-binding wart virus antibodies were present in 15% of the patients prior to the treatment and in 43% after the conclusion of treatment. This investigation provides a new method of treatment of verrucae vulgares and suggests that regression in warts is immunologically conditioned. On account of the risk of allergic side effects, the method should be carried out in special departments only.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The sensitization capacity of ethylenediamine was examined by the guinea pig maximization test and compared with dinitrochlorobenzene. Ethylenediamine was found to be a potent sensitizer. An attempt at oral induction of unresponsiveness (tolerance) was unsuccessful with ethylenediamine and DNCB and the same negative result was obtained with intravenous injection of ethylenediamine. Only by the intravenous injection of dinitrobenzene sulfonic acid was unresponsiveness successfully established in 90% of the guinea pigs.
32 adult hospitalized patients with common skin disorders were controlled in a double-blind comparison study with clobetasol propionate (Dermovat) and betamethasone-17,21-dipropionate (Diproderm) with regard to adrenal suppression. The latter, when assessed by plasma cortisol, was significantly greater in the dermovat-treated groups after the 1st and 2nd week with daily treatment with both 25 g and 15 g ointment. Daily treatment of skin areas greater than 25% with 25 g Diproderm also showed clear adrenal suppression, whereas no such effect was obtained with daily treatment with 10 g Diproderm of skin areas greater than 15%. In all cases, plasma cortisol levels were normal 1--2 weeks after the end of topical treatment.
Explore the source record for details and available documents.
Cross allergy between paranitro compounds including DNCB and chloramphenicol, was studied in 42 patients. A total of 27 had been primarily sensitized to DNCB, and 15 patients with eczema exhibited a delayed-type reaction to chloramphenicol, showing a positive patch test. All 15 patients with chloramphenicol allergy cross reacted with chloramphenicol succinate and chloramphenicol palmitate. Three of them cross reacted with paranitrobenzoic acid, and two of these also with paradinitrobenzene. None of the 15 patients cross reacted with DNCB in acetone or DNCB in petrolatum, and none reacted to picric acid, paranitrophenol or dinitroorthocresol. The 27 patients primarily sensitized to DNCB did not cross react with any of the paranitro compounds studied, in particular not with chloramphenicol or its salts. Thus, the study confirms the specificity of the DNCB sensitivity.
Direct and indirect immunofluorescence investigations performed for 11 patients with scabies. All patients had punch biopsies taken from (1) a lesion containing Sarcoptes scabiei, (2) an inflammatory papule which did not contain a mite, and (3) normal skin. In four patients IgE deposits were found in the vessel walls of the upper dermis both in biopsies containing mits and biopsies of inflammatory papules with no mites. No IgE deposits were found in biopsies of normal skin from the same patients. Two patients had IgM and/or C3 deposits along the basal membrane in biopsies containing mites and one of them also had C3 in this area in the biopsy from a papule with no mite, as well as normal skin.
Ten patients with long-standing areate type alopecia totalis were sensitized with 1-chloro, 2, 4-dinitrobenzene (DNCB). Following sensitization they were painted once weekly on a 40 X 20 mm area of the vertex with DNCB in acetone, in concentrations adjusted to the allergic response. After 7 weeks, growth of hair was seen in the painted area in 3 patients and after 8 weeks all over the scalp in 3 other patients.
Explore the source record for details and available documents.