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Biomedical subjects

K Endou

Publications and source records attributed to K Endou.

39 records · Page 3Linked to original sources

Clinical usefulness of computer diagnosis in automated electrocardiography.

We evaluated the clinical usefulness of the automated ECG analysis system with the Bonner I program based on 1,460 ECGs of which 45.8% were abnormal. Both computer and physician agreed in 93.8% of the 1,460 cases on rhythm analysis, in 89.5% on contour analysis and in 83.6% on both rhythm and contour analysis. Myocardial infarction, LVH and ST abnormality were correctly diagnosed in 81.0, 69.7 and 82.0%, respectively, and error ratios of these diagnoses were 0.50, 0.58, 0.52, respectively. WPW syndrome and electronic pacemaker were rarely diagnosed by the computer. 43 cases diagnosed by the computer as 'normal sinus rhythm or sinus bradycardia with normal contour ECG' were of abnormal ECGs. The most frequent causes of disagreement between computer and physician in the diagnosis of myocardial infarction, LVH and ST abnormality were differences in criteria. Since there are several cases of misdiagnoses in the clinically important ECG abnormalities, such as myocardial infarction, it will still be necessary for cardiologists to review all computer-processed ECGs. Nevertheless, the physician's clerical work would be reduced greatly by using the system when we consider the fact that both computer and physician agreed on the diagnosis of rhythm and contour analysis in 83.6% of the 1,460 cases.

Diagnosis, Computer-Assisted↗

Hemodynamic changes during hemodialysis.

35 patients with chronic renal failure were examined during the first 2 h of hemodialysis by invasive and non-invasive methods. The cardiac output was determined by the dye dilution technique in 11 of these patients and by Swan-Ganz catheterization in 5. In the patients without severe myocardial damage, the cardiac output during hemodialysis showed a significant increase (p less than 0.05), accompanied by a significant decrease of both mean blood pressure (p less than 0.05) and total peripheral resistance (p less than 0.05). Mean pulmonary artery pressure and pulmonary artery wedge pressure were reduced in all cases during hemodialysis. The increase in cardiac output during hemodialysis in patients with chronic renal failure may be attributed to the decrease in afterload.

Blood Pressure↗

Effects of CM7857, a derivative of disopyramide, on electrophysiologic properties of canine Purkinje fibers and inotropic properties of canine ventricular muscle.

Effects of CM7857 on electrophysiologic properties in canine Purkinje fibers and inotropic effects in canine ventricular muscle were studied. As CM7857 is a derivative of disopyramide phosphate, the effects of CM7857 (5 mg/L, 1.5 X 10(-5) M) were compared with those of disopyramide phosphate (5 mg/L, 1.4 X 10(-5) M). CM7857 significantly lowered the maximum rate of rise of phase 0 (Vmax) from 351.5 +/- 50.6 V/s (mean +/- SE, n = 5) to 283.6 +/- 33.0 V/s, and conduction velocity from 2.68 +/- 0.56 m/s to 1.70 +/- 0.28 m/s. The automaticity of Purkinje fibers was depressed by CM7857 as the result of reduction in the slope of phase 4. These effects were comparable to those of disopyramide. A marked difference between CM7857 and disopyramide was observed in the effect on action potential duration. APD90 was significantly shortened from 327.4 +/- 14.8 ms (n = 8) to 279.9 +/- 12.9 ms by CM7857, whereas disopyramide did not show any significant changes in APD90. As the CM7857-induced shortening of APD disappeared in low [Na+]o or low [K+]o concentration, it may be attributed to the lowering effect of "window current," a steady-state sodium current, maintaining action potential plateau. Effective refractory period (ERP) did not show any significant change. An acetylstrophanthidin-induced oscillatory afterpotential was significantly depressed by disopyramide, but not by CM7857. Isotonic contraction and isometric contraction of the right ventricular trabecullae were depressed by both drugs.

Action Potentials↗