Biomedical subjects

K E Prescott

Publications and source records attributed to K E Prescott.

4 recordsLinked to original sources

PubMed2001

Tests for order restrictions in binary data.

In this article, a general procedure is presented for testing for equality of k independent binary response probabilities against any given ordered alternative. The proposed methodology is based on an estimation procedure developed in Hwang and Peddada (1994, Annals of Statistics 22, 67-93) and can be used for a very broad class of order restrictions. The procedure is illustrated through application to two data sets that correspond to three commonly encountered order restrictions: simple tree order, simple order, and down turn order.

Animals↗

PubMed1996

Hunter-McAlpine craniosynostosis phenotype associated with skeletal anomalies and interstitial deletion of chromosome 17q.

Hunter-McAlpine syndrome is an autosomal dominant disorder consisting of variable manifestations including craniosynostosis, almond-shaped palpebral fissures, small mouth, mild acral-skeletal anomalies, short stature, and mental deficiency. We report on a 9-year-old boy with this phenotype with more severe skeletal abnormalities than previously described. Chromosomes showed del(17)(q23.1-->q24.2); the more severe phenotype may be explained by the deletion. The deletion also suggests the possibility that the gene for Hunter-McAlpine syndrome might map to that region.

Abnormalities, Multiple↗

PubMed1995

Peak nasal inspiratory flow measurement: an investigation in children.

Theoretically measurement of peak nasal inspiratory flow (PNIF) has promise as a method to objectively evaluate children with nasal airway obstruction. This study establishes normative data for children up to 8 years of age. PNIF increases linearly from a mean value of 30 l/min in early infancy up to a mean value of 80 l/min at age 8 years, apart from a dip at 3 years. There is a reasonably linear incremental rise with increasing height and weight. However, since results depend on both the degree of co-operation of the child and on the subjective impression of the observer as to when a maximal inspiratory effort has been made, there may be drawbacks to its use as a routine clinical method of nasal airway obstruction assessment.

Body Height↗

PubMed1993

Natural history of the recombinant (8) syndrome.

The recombinant 8[Rec(8)] syndrome [rec(8), (8qter-->8q22.1::8p23.1-->8qter] is due to a parental inv(8)(8pter-->8p23.1::8q22.1-->8p23.1::8q22+ ++.1-->8qter). All inv(8) parents we have studied were of Hispanic origin. The Rec(8) phenotype consists of a characteristic set of minor facial anomalies, cardiovascular and other major malformations, and moderate to severe mental retardation. The clinical phenotype is relatively consistent in all published cases; however the natural history of the condition has remained unknown. Retrospective and prospective information on 42 propositi, spanning a period from 5 days to 23 years, allowed us to define the natural history of this syndrome, tabulate the frequency and the evolution of phenotypic abnormalities, and share our experience with different therapeutic approaches.

Abnormalities, Multiple↗