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Biomedical subjects

K Drescher

Publications and source records attributed to K Drescher.

23 records · Page 2Linked to original sources
PubMed1982

[Investigations under anesthesia on the effects of endogenous and exogenous factors on corneal sensitivity].

Corneal touch threshold and/or reaction time by the local anaesthetic benoxinate were determined in 91 males and females of different age groups. The corneal sensitivity decreased with advancing age, especially in the centre of the cornea. Comparing male and female subjects, the measurements of females over 40 years were significantly higher at all points of measurement than for male subjects in the same age group. In the nasal area there was a higher corneal sensitivity than in the temporal area in all subjects. Also the reaction time of equal doses of benoxinate is age-dependent meaning that the reaction time increases with age. Genetically determined differences could be supposed but are not yet certain. In order to determine that a corneal sensitivity deficiency exists, it is necessary to take age, sex and exact measurement points into account.

Adult↗
PubMed1979

Time course of clinical-chemical parameters under long-term lithium treatment.

In 40 manic-depressive patients under lithium prophylaxis the time course of the following variables has been studied over a period of 3 years (retrospective investigation): Diff. blood smear, hemoglobine, leucocytes, electrolytes in serum, electrophoresis, GPT, GOT, alcaline phosphatase, creatinine and urea in serum. Appr. 1000 blood samples were evaluated. The issue of additional psychotropic medication has been given special consideration.

Adult↗
PubMedDate not supplied

Logistic analysis of studies with two-stage sampling: a comparison of four approaches.

This paper discusses the analysis of two-stage studies where covariates are missing or measured with error at the first stage of sampling and are validated at the second stage in a subsample. Four recently developed approaches, the weighted pseudo-likelihood method of Flanders and Greenland (1991), the pseudo-conditional likelihood methods of Breslow and Cain (1988) and Schill et al. (1993) and the maximum likelihood estimate obtained via the EM-algorithm (Wacholder and Weinberg, 1994) are reviewed, and some connections between them are established. It is shown that, with respect to odds ratio estimation, case-control designs can be analysed as if first-stage sampling had been prospective. The procedures are numerically compared with respect to asymptotic relative efficiency in a missing value setting.

Algorithms↗