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Biomedical subjects

K Danno

Publications and source records attributed to K Danno.

At least 91 records · Page 5Linked to original sources
PubMed1982

Topical methoxsalen followed immediately by long-wave UV irradiation. A preliminary report on the treatment of psoriasis.

In the treatment of psoriasis with topically applied methoxsalen, the patient is exposed to long-wave UV (UV-A) energy two hours after the application of methoxsalen. Using the guinea pig as an experimental model, we found that UV-A irradiation given immediately after the topical application of methoxsalen resulted in the notable suppression of tritiated thymidine incorporation into epidermal basal cells. This finding suggests that the rate of suppression of epidermal DNA synthesis by PUVA (methoxsalen plus UV-A light) may not correlate with the interval between methoxsalen application and UV-A irradiation. This modified method of PUVA therapy (immediate irradiation) was successfully used in the treatment of psoriasis.

Administration, Topical↗
PubMed1982

Coexistence of Kimura's disease and lichen amyloidosus in three patients.

Three patients had Kimura's disease with multiple asymptomatic subcutaneous tumors of 11 to 20 years' duration on the head, soft palate, elbow, or inguinal regions associated with enlarged regional lymph nodes. In each patient, lichen amyloidosus had also developed on the extensor surfaces of the extremities during the past 12 to 20 years. Blood eosinophilia (26% to 75%) was present in all cases. The possible pathogenetic relationship between Kimura's disease and primary localized cutaneous amyloidosis is discussed.

Adult↗
PubMed1981

Suppression of active Arthus reaction by colchicine.

An effect of colchicine on the active Arthus reaction in rabbits was investigated in vivo with simultaneous evaluation of in vitro chemotactic activity of polymorphonuclear leukocytes. Arthus reactions were induced by intracutaneous injection of ovalbumin into rabbits preimmunized with ovalbumin. Colchicine, 1 mg/kg or 2 mg/kg, injected intraperitoneally one hour prior to the induction of the Arthus reaction, suppressed erythema and induration at 12 h, when histology showed decreased numbers of C3, suggestive of the presence of immune complexes, persisted to 24 h. In vitro chemotaxis of polymorphonuclear leukocytes using Boyden chamber techniques revealed suppression of the activity in the colchicine-treated animals at 6 and 12 h. These findings suggest that colchicine inhibits vascular injury by interfering with directional chemotaxis of polymorphonuclear leukocytes to the lesional sites.

Animals↗
PubMed1981

Sulphhydryl and disulphide stainings of subepidermal hyaline bodies.

The localization of sulphhydryl (-SH) groups and disulphide (-S-S-) bonds in subepidermal hyaline bodies was examined using histochemical techniques with the specific fluorescent thiol reagent (DACM). In lichen planus, hyaline bodies showed -S-S- but not -SH staining, suggesting that erythematosus and dermatomyositis, there were not only -S-S-positive hyaline bodies, considered of epidermal origin, but also -S-S- negative ones. The latter may consist of dermal components, since no dermal components are stainable with DACM. DACM staining therefore seems to be of help in determining the origin of hyaline bodies.

Dermatomyositis↗
PubMed1981

Sulphhydryl and disulphide stainings of amyloid: a comparison with hyaline body.

Histochemical staining for sulphhydryl (-SH) groups and disulphide (S-S) bonds was undertaken in 10 cases of cutaneous amyloidosis using the new fluorescent thiol reagent. A weak S-S fluorescence (but not -SH) was detected in dermal amyloid, suggesting that cross-linking of -SH groups may occur in amyloidogenesis. Since in normal skin S-S bonds were stained only in the horny layer and negligibly in the dermis, our findings seem to support the view that amyloid is derived at least partially from epidermal cells.

Amyloid↗
PubMed1981

Potassium iodide in the treatment of erythema nodosum and nodular vasculitis.

Twenty-nine patients with erythema nodosum, nodular vasculitis, or erythema nodosum-like lesions associated with Behçet's syndrome were treated with potassium iodide. Administration of the drug for systemic effect showed a substantial effect in 11 of 15 patients with erythema nodosum, seven of ten with nodular vasculitis, and one of four with leg lesions of Behçet's syndrome. Relief of subjective symptoms, including tenderness, joint pain, and fever, occurred within 24 hours. Substantial improvement in the eruption occurred within a few days, and the lesions disappeared completely ten to 14 days after therapy was initiated. The patients to whom the medication was administered shortly after the initial onset of erythema nodosum seemed to respond most satisfactorily. The effect of the drug was marked in the patients with positive C-reactive protein reactions, joint pains, and/or fever. Possible mechanisms by which potassium iodide exerts its effect are discussed.

Adult↗
PubMed1980

Benign and neoplastic eosinophilic staining cells: an immunofluorescence study.

Deposition of immunoglobulins, complement and fibrinogen on eosinophilic staining cells was investigated using direct immunofluorescence techniques. Serum factor deposition was detected on benign epidermal eosinophilic cells seen in pityriasis lichenoides et varioliformis acuta, sunburn erythema and, in addition, on subepidermal hyaline bodies in lichen planus; no such deposition occurred on neoplastic eosinophilic cells in Bowen's disease and squamous cell carcinoma. The qualitative findings of immunofluorescence microscopy seem to be different in inflammatory and malignant dermatoses.

Complement System Proteins↗
PubMed1980

Histochemical staining of sunburn cells for sulphhydryl and disulphide groups: a time course study.

Ultraviolet light (UV)-exposed rabbit skin was stained with a fluorescent thiol reagent or haematoxylin and eosin to investigate a time relationship between histochemical stainings for sulphhydryl (-SH) and disulphide (S-S) groups and sunburn cell (SBC) production. SBCs appeared by 8 h after irradiation, increased and showed a peak at 48 h, then declined to zero by 96 h. SBCs showing -SH staining increased to a maximum of 41--59% at 24--48 h and declined to 26--45% by 72 h, whereas S-S-stained SBCs were only a few at 8--24 h and then increased up to 65--85% by 72 h. The results seem to indicate that S-S linkage may occur in the process of SBC production.

Animals↗
PubMed1980

Central pitting of molluscum contagiosum.

Histological examination of 42 early lesions of molluscum contagiosum was performed. At the top of the molluscum papule, the epidermis cylindrically hung down into the dermis, thus forming an epidermal cylinder with a narrow canal. Acanthomatous change occurred at the bottom of the epidermal cylinder. Thirteen of the 42 molluscum lesions showed a direct connection with components of hair follicle. It is suggested that the central pitting of molluscum contagiosum may be the ostium of pilar infundibulum.

Child↗
PubMed1980

Treatment of acute febrile neutrophilic dermatosis (Sweet's Syndrome) with potassium iodide.

6 cases with acute febrile neutrophilic dermatosis (Sweet's syndrome) responded rapidly and dramatically to treatment with potassium iodide. All patients became afebrile and symptom-free within 24--48 h after therapy. The cutaneous eruptions subsided completely in 3--5 days. 5 of the patients received the drug only for 2 weeks, but they have had no recurrences. Although the remaining 1 patient had shown minor recurrences after cessation of the medication, he was free of all symptoms during the therapy. The mode of the action of potassium iodide is also discussed.

Adult↗
PubMed1980

Acute generalized pustular bacterid and immune complexes.

The case is described of a 39-year-old man with acute generalized pustular bacterid and high Clq-binding activity in the sera during the active stage. Histamine-induced vascular changes studied by immunofluorescence microscopy revealed a perivascular deposition of IgM and C3. These findings support the view that leukocytoclastic vasculitis underlying the subcorneal pustules is mediated by immune complex deposition.

Adult↗
PubMed1979

Granulomatous inflammation in normal and athymic mice infected with schistosoma mansoni: an ultrastructural study.

Inflammatory cell types and their interrelationships were studied in hepatic schistosome egg granulomas by correlated light and electron microscopy in thymus-intact and athymic mice. Intact animals developed large granulomas composed of phagocytes, stimulated macrophages, epithelioid cells, eosinophils and mast cells. The lesions peaked in size between 10--14 weeks after infection and tended to heal after 16 weeks. In athymic mice only phagocytes, stimulated macrophages and possible epithelioid cells appeared in the granulomas which were much smaller and less well organised than in intact mice. Virtually no eosinophils or mast cells entered the granulomas. These findings support the idea that development of granulomatous inflammation per se is not determined by CMI, but T cell co-operation seems to be required for its full expression in schistosomiasis. Since CMI closely regulates ingress of eosinophils and mast cells into the granuloma, the nature of T cell co-operation probably occurs at several levels in this complex infectious granuloma.

Animals↗