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Biomedical subjects

K Daniels

Publications and source records attributed to K Daniels.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Water birth: the newest form of safe, gentle, joyous birth.

This paper underscores the serious problems facing institutionalized obstetrics in the United States (demonstrated by alarming cesarean rates) and provides information about a new, safe, gentle birth alternative that uses water during labor and delivery. Pioneered by doctors, nurses, and midwives to lower cesarean rates and increase possibilities for natural childbirth, water birth assists the mother in achieving deep relaxation during labor and thereby alleviates much of the pain and stress of birth for both mother and baby. Water birth may be a safe, helpful, and easy to implement method of improving obstetrical statistics in the U.S. and should be investigated by those health care providers concerned with promoting humanistic childbirth practices.

Delivery, Obstetric↗
PubMedDate not supplied

Levels of cotinine associated with long-term ad-libitum nicotine polacrilex use in a clinical trial.

Studies of nicotine replacement by 2 mg nicotine polacrilex gum (NG) have typically found that one half to one third of plasma nicotine in recent smokers is replaced. This 5-year study sought to find the extent of nicotine replacement among ex-smokers in the longer term and to identify a mechanism for this relationship. The sample was the special intervention group (N = 3923) in the Lung Health Study, a controlled clinical trial involving smoking cessation. The extent of nicotine replacement was assessed by levels of salivary cotinine. Cotinine levels of ex-smokers using NG after 1 year (219 +/- 149 ng/ml) were similar to those in continuing smokers (290 +/- 159 ng/ml). After 5 years, cotinine levels were the same for NG-using ex-smokers (316 +/- 276 ng/ml), NG-using smokers (309 +/- 240 ng/ml), and NG-non-using smokers (311 +/- 198 ng/ml). Salivary cotinine among NG users at 1 year was only weakly correlated with baseline cotinine levels prior to smoking cessation. Although NG users appear to re-establish cotinine levels characteristic of their smoking, the mechanism by which this occurs remains unclear.

Adult↗
PubMedDate not supplied

Mechanical stimulation of dorsal root ganglia induces increased production of substance P: a mechanism for pain following nerve root compromise?

The undecapeptide, substance P, is known to be synthesized in cell bodies of dorsal root ganglia. This neuropeptide is also known to modulate sensory, nociceptive transmission postsynaptically on dorsal horn interneurons. In the animal model used in the current study, experimental mechanical stimulation of dorsal root ganglia and nerve roots increased the amounts of substance P, as well as substance P immunoreactivity in cell bodies of the dorsal root ganglia and in the substantia gelatinosa of the spinal dorsal horn that the cell bodies innervated. These results were determined by using both immunohistochemistry and radioimmunoassay. This study suggests that substance P may modulate nociception when lumbar nerve roots are stimulated mechanically.

Animals↗