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Biomedical subjects

K Dalton

Publications and source records attributed to K Dalton.

At least 37 records · Page 2Linked to original sources
PubMed1991

Inpatients with AIDS and AIDS-related complex: economic inpact on hospitals in North Carolina.

To determine the economic impact of acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) cases on North Carolina hospitals, we collected inpatient data from all North Carolina hospitals on charges and number of patients discharged with these diagnoses. More than 97% of the state's hospitals responded to the survey for the study year (1987-1988). There were 540 AIDS/ARC discharges from 58 North Carolina general hospitals and 125 AIDS/ARC discharges from 13 other types of hospitals, for a statewide total of 665 patients. The total general hospital charges for AIDS/ARC inpatients in North Carolina were approximately $7.7 million per year, and almost $2 million of these charges were uncompensated by any insurance. The greatest burden of cost for this care was borne disproportionately by 15 of the 58 general hospitals, accounting for 82% of the discharges.

AIDS-Related Complex↗
PubMed1990

The aetiology of premenstrual syndrome is with the progesterone receptors.

Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are widely distributed in target cells throughout the body (1, 2, 3, 4, 5, 6, 7). It suggests also why measuring P blood levels is of no value in PMS (8, 9, 10, 11); why pharmacological doses of P are required (8); and explains the failure of current double blind trials using low dose P (12, 13, 14, 15, 16).

Female↗
PubMed1990

An open, randomized comparative study of a low-strength frusemide/amiloride combination and bumetanide/potassium chloride in the treatment of mild congestive cardiac failure.

In an open, randomized, parallel group study lasting 8 weeks, nine males and nine females with mild congestive cardiac failure were initially treated daily with 20 mg frusemide/2.5 mg amiloride or 0.5 mg bumetanide/573 mg potassium chloride. In two patients receiving the frusemide combination and in one receiving the bumetanide combination, the daily dose was doubled after 2 weeks' treatment because of inadequate control of symptoms. Mild congestive cardiac failure symptoms (raised jugular venous pressure, oedema and dyspnoea at rest and on effort) were controlled in 9/10 patients receiving frusemide/amiloride but two patients receiving bumetanide/potassium chloride still had mild oedema after 8 weeks. Both treatments were well tolerated overall and there were no clinically significant changes in plasma electrolytes, although one patient treated with frusemide/amiloride was withdrawn due to adverse events.

Adult↗
PubMed1987

Characteristics of pyridoxine overdose neuropathy syndrome.

A newly recognised neurotoxic syndrome due to pyridoxine (B6) overdose is described. It is the largest series of B6 intoxication hitherto reported. A raised serum B6 level was present in 172 women of whom 60% had neurological symptoms, which disappeared when B6 was withdrawn and reappeared in 4 cases when B6 was restarted. The mean dose of B6 in the 103 women with neurological symptoms was 117 +/- 92 mgs, compared with 116.2 +/- 66 mgs in the control group. There was a significant difference (P less than 0.01) in the average duration of ingestion of B6 in the neurotoxic group of 2.9 +/- 1.9 years compared with 1.6 +/- 2.1 years in controls. The symptoms were paraesthesia, hyperaesthesia, bone pains, muscle weakness, numbness and fasciculation, most marked on the extremities and predominantly bilateral unless there was a history of previous trauma to the limb. These women were taking a lower dose of B6 than previously described (1,2), which may account for the complete recovery within 6 months of stopping B6.

Dose-Response Relationship, Drug↗
PubMed1982

What is this PMS?

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Diagnosis, Differential↗