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Biomedical subjects

K D Gruskin

Publications and source records attributed to K D Gruskin.

3 recordsLinked to original sources

Head trauma in children younger than 2 years: are there predictors for complications?

OBJECTIVES: To determine the incidence of skull fracture (SF) and intracranial injury (ICA) among children younger than 2 years evaluated in a pediatric emergency department for head trauma; whether historical features and/or physical findings are predictive of injury type; and whether clinical criteria could allow a selective approach to radiographic imaging. DESIGN: Retrospective medical record review. SETTING: Tertiary pediatric emergency department. PATIENTS: Case series of 278 children aged younger than 24 months evaluated for head injury. MAIN OUTCOME MEASURES: Presence of SF and/or ICA. RESULTS: Diagnoses at discharge included 227 minor head injuries, 39 isolated SF, 9 ICA with SF, and 3 isolated ICA. Children younger than 12 months had the highest incidence of SF/ICA (29%) vs 4% for children aged 13 to 24 months (P<.001). Seven percent of complications from SF/ICA resulted from falls 3 ft (0.9 m) or less [corrected]. Incidence of behavioral change, loss of consciousness, emesis, and seizures did not differ significantly between those with minor head injuries and those with SF/ICA. Scalp abnormalities were more common in children with SF/ICA (P<.001). Sixty-two percent of children with isolated SF and 58% of children with ICA had no history of loss of consciousness, emesis, seizure, or behavioral change. Ninety-two percent of children with isolated SF and 75% of children with ICA had normal levels of consciousness and nonfocal neurologic examinations at diagnosis. Among children who fell 3 ft or less (0.9 m) [corrected] and had no loss of consciousness, emesis, seizure, behavioral change, or scalp abnormality, none of 31 (95% confidence interval [CI], 0-0.10) children younger than 24 months and none of 20 (95% CI, 0-0.15) children younger than 12 months had SF/ICA. CONCLUSIONS: Both SF and ICA are common in children younger than 2 years evaluated for head trauma. Children younger than 12 months are at highest risk. Injuries resulted from relatively minor falls and occurred in alert, neurologically normal children. Clinical signs and symptoms were insensitive predictors of SF/ICA; however, a grouping of features (fall < or = 3 ft [0.9 m], no history of neurologic symptoms, and normal scalp physical examination results) identified a subset of children at low risk for complications.

Accidental Falls↗

Possible origin of a calmodulin gene that lacks intervening sequences.

The divergent, muscle-specific allele of the chicken calmodulin gene contains no intervening sequences and apparently was produced by a reverse transcriptase-mediated event. The nucleotide and deduced amino acid sequences of this gene were compared with nucleotide and amino acid sequence data of other known calmodulin genes in order to investigate its evolutionary history. These comparisons, as well as the CpG dinucleotide content, support the conclusion that this highly divergent chicken calmodulin gene did not exist for any significant period of times as a pseudogene and suggest plausible alternative genetic histories. The most parsimonious history involves the viral import of a very old foreign gene of high CpG content.

Amino Acid Sequence↗

Molecular genetics and computer analyses.

This issue of CABIOS contains a set of reviewed papers which relate to the recent Macromolecules, Genes and Computers International Workshop and Symposium held August 12-17, 1986 in Waterville Valley, NH. This introductory article reviews that meeting and those ideas which will provide a useful context for the continuing research and discussions on molecular genetic analyses contained within this issue.

Amino Acid Sequence↗