Paracervical nerve block in labour using bupivacaine (Marcain).
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Anesthesia, Obstetrical↗
Biomedical subjects
K Cooper
Publications and source records attributed to K Cooper.
PCDD, PCDF, and PCB in farm-raised catfish from southeast United States--concentrations, sources, and CYP1A induction.
Nine catfish fillets, three catfish nuggets, two feed samples, and one pond sediment were analyzed for PCDD, PCDF, and PCB. Farm-raised catfish from Mississippi, Alabama, and Arkansas contained significant levels of 2,3,7,8-substituted PCDD and PCDF. In addition, a large number of non-2,3,7,8-substituted congeners were present in all samples. The catfish fillets and catfish nuggets also contained high concentrations of dioxin-like PCB, as well as a number of non-dioxin-like PCB. The TEQ based on PCDD and PCDF ranged from 9.5 to 43.0 pg/g lipid and the TEQ based on PCB ranged from 0.45 to 4.9 pg/g lipid for all catfish samples. The dioxin-like PCB contributed 4-16% to the total TEQ (PCDD/PCDF/PCB) for the catfish samples. The major source for the PCDD, PCDF, and PCB appears to be from feed and not from pond sediment. Immunoreactive CYP1A protein was elevated 2.5 fold in the pond-raised catfish compared to the aquarium-raised one. The results of this study suggest that the PCDD/PCDF are more important than the PCB in the CYP1A induction.
Agriculture↗
Discovery of fluconazole, a novel antifungal agent.
Fluconazole, 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol, is the result of a research program aimed at the development of a broad-spectrum antifungal agent active by both the oral and the intravenous routes for the treatment of superficial and systemic infections. The program began in 1978, and azole derivatives were chosen as a starting point because they were generally well tolerated and offered the advantage of a selective mode of action--inhibition of fungal sterol C-14 demethylation. Initial investigations focused on imidazole derivatives, but attention soon switched to triazole analogues because of their reduced susceptibility to metabolic activity. Polar derivatives were emphasized in an effort to facilitate the attainment of high levels in the blood and to reduce metabolic breakdown still further. This strategy resulted in a number of novel 1,3-bis-triazole-2-arylpropan-2-ol derivatives with good activity in a range of models of fungal infection. These models included systemic fungal infections in both normal and immunosuppressed animals and superficial infections in animals with normal immune function. The 2,4-difluorophenyl analogue, fluconazole, was chosen for development on the basis of an optimal combination of antifungal efficacy, pharmacokinetic characteristics, aqueous solubility, and safety profile.
Animals↗
Homeostasis: restoring the internal wellbeing in patients/clients.
This article gives a historical perspective of homeostasis and explores the concepts surrounding the term. The importance of the internal environment and the dynamic nature of homeostasis are discussed. Issues of homeostatic control and maintenance are highlighted and the role of feedback mechanisms is clarified. A rationale is presented to support the argument that the objective of holistic nursing care is to restore physical and emotional homeostasis, i.e. to facilitate the restoration of the internal wellbeing in our clients/patients. Two aspects of a non-homeostatic model of health, namely the mind-body dualism and the reductionist approach, are considered.
Feedback↗
Concept mapping: promoting science learning in BN learners in Australia.
BACKGROUND: We reviewed the process of using concept mapping as a methodology to teach science to RNs in a bachelor degree of nursing program in Australia. METHOD: The technique was used for two classes of students in the science unit during 1995 with work packages and independent student learning being the focus of the unit. RESULTS: Both instructors and students found the experience mainly positive. It helped the students become more independent learners, have a greater confidence in their knowledge of science, and allowed their understanding of science in their practice to become more meaningful and personalized. For the instructors it allowed them to concentrate on students with learning difficulties because they had less face-to-face teaching hours. Major issues arising from the process related to how to balance science content and the techniques of concept mapping and how to more effectively assess the learning outcomes of the students. CONCLUSION: Concept mapping is a useful technique to link science and nursing practice. Not only can it be used in academic programs to teach the science underlying practice, it can be used in the clinical area to teach patients. As a technique it works well in staff development and continuing education where the focus is on elucidating the rationale for inuring practice and providing evidence for the value of this practice.
Australia↗
Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy.
Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied.
Abducens Nerve↗
Tradimus. Student placements: a casualty of ward.
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Communication↗
Choroid plexus carcinoma. Cytologic identification of malignant cells in ascitic fluid.
Abdominal deposits of a choroid plexus carcinoma in a patient with a ventriculoperitoneal shunt were cytologically diagnosed by examination of ascitic fluid after regression of the primary tumor. The morphology of the malignant cells in ascitic fluid was more similar to that of mesothelial cells than to the appearance of cells from this lesion in cerebrospinal fluid.
Ascitic Fluid↗
Perceptions of side effects following axillary block used for outpatient surgery.
BACKGROUND AND OBJECTIVES: The study evaluated patient perceptions of side effects related to axillary block (AB) and how they might influence a patient's decisions about subsequent ABs. METHODS: A questionnaire concerning the occurrence and duration of side effects following AB and patient preference for a subsequent AB was completed and returned by each of 1,149 patients. All ABs were performed using a 22 gauge short bevel needle. In all 86.5% had orthopedic surgery, with the remainder vascular access procedures. Three AB techniques and two anesthetic solutions were used. RESULTS: Patient-reported incidences of side effects were bruising, 19.1%; soreness, 39.7%; persistent numbness, 11.0%; and nausea, 10.8%. Bruising was reported more frequently by female patients, those undergoing orthopedic procedures, and those between 20 and 30 and over 80 years of age. Soreness was reported more frequently in orthopedic procedures and by those aged 20 to 30. Technique used did not affect the incidence of side effects or patient willingness to have a repeat AB. Ninety-three percent expressed willingness to have another AB; this was affected by whether the patient experienced a side effect, the duration of the side effect, and by the number of side effects experienced. Those between the ages of 20 and 40 were less willing to have another AB. CONCLUSIONS: Even though 51% of the patients reported at least one side effect, 93% would choose to have another AB, indicating a high overall satisfaction with AB anesthesia, which significantly decreased as the number and duration of side effects increased.
Adolescent↗