Biomedical subjects
K Cooper
Publications and source records attributed to K Cooper.
Long-chain aliphatic fatty acids and phytanic acid simultaneously measured by dual-column capillary chromatography.
A method is described for simultaneously measuring long-chain aliphatic fatty acids and phytanic acid in plasma, for the diagnosis of disorders associated with peroxisomal defects, eliminating the need for two separate chromatographic runs to resolve all of the analytes. In addition, the simultaneous, dual-column analysis allows confirmation of the identity and quantity of the individual fatty acids, thus adding a degree of certainty when results are used for interpretation and differential diagnosis of the many clinical manifestations of peroxisomal defects.
Cerebral blastomycosis. A report of 2 cases.
Following recent documentation of blastomycosis in the RSA, a report of a further 2 cases in Natal is presented. The unusual feature of both cases was the presence of central nervous system involvement. In the first patient intracerebral involvement occurred after apparent good response to ketoconazole when he defaulted from therapy after 3 months. The second patient presented with cerebral involvement and died soon after admission to hospital.
Primary serous papillary carcinoma of the peritoneum. A case report.
A primary serous papillary carcinoma of the peritoneum in a 38-year-old black woman is described. The autopsy results and histological, cytological, immunohistochemical and ultrastructural findings are discussed.
Group A beta-haemolytic streptococcus causing disseminated intravascular coagulation and maternal death.
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Multicentric reticulohistiocytosis in a black patient. A case report.
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Drug-receptor interactions and drug design.
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Design and evaluation of a systemically active agent, fluconazole.
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Localized osseous cryptococcal infection. Report of 2 cases.
Cryptococcal infection in man is widely disseminated and commonly involves the central nervous system. Primary bone involvement is rare. We report on 2 cases of localized cryptococcal osseous lesions treated successfully by surgery.
Ovarian follicular growth and maturation in the domestic pigeon and guinea fowl (Numida meleagris).
Yolks of pigeon and guinea fowl eggs were examined for the number of dichromate-staining rings. Estimates of the time for rapid follicular development using this technique were 5.1 and 5.6 days for pigeons and guinea fowl, respectively. Another measure of follicular development based on the incorporation of Sudan dyes into the yolk yielded an estimate of 6.5 and 8.3 days for pigeons and guinea fowl, respectively. Using one and two-egg clutches, no differences due to clutch position were observed in either species. There was a significant difference (P less than or equal to .01) between results obtained with the two techniques for measuring the period of rapid yolk deposition. The dichromate technique can give valuable data relative to yolk deposition, especially in species where it is impractical to daily catch and administer Sudan dyes. But the tendency to underestimate the period of follicular growth means that caution must be exercised in comparing results obtained with that technique and the more labor-intensive Sudan dye incorporation method. The time from the end of yolk deposition until oviposition is defined as the rest period. This interval was 1.5 days for pigeons and 1.7 days for guinea fowl. This is considerably longer than the rest period of Coturnix quail but similar to that found in turkeys and chickens.
The critical difference. Ectopic pregnancy.
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Takayasu's aorto-arteritis. A report of 11 cases at King Edward VIII Hospital, Durban.
Eleven cases of histologically confirmed Takayasu's aorto-arteritis seen at King Edward VIII Hospital, Durban, are presented. The morphological features of the various histological stages are highlighted. The anatomical distribution of lesions is also discussed.
Rhinosporidiosis at King Edward VIII Hospital, Durban--1976-1985. A report of 6 cases.
Six cases of the fungal infection, rhinosporidiosis, are documented. Clinical, light microscopic and electron microscopic features of the causative organism (Rhinosporidium seeberi) are presented.
Swim stress reduces chronic pain in mice through an opioid mechanism.
Chronic nociception has been studied in male mice by means of the formalin test in which forelimb motor behaviour is scored after subcutaneous formalin injection. The rating remained above 2.0 for 30 min after the injection (scale range 0-3). The magnitude of the nociception has been compared with that reported in other animal types. Mice are more sensitive than rats, cats and monkeys. The stress of a swim of 3 min has been found to reduce nociception by up to 25%. This analgesia is wholly opioid in nature, being abolished by a moderate dose of naloxone (1 mg/kg).
Nephrotoxicity of common drugs used in clinical practice.
Drug-induced nephrotoxicity is an increasingly recognized complication of a wide variety of therapeutic agents. The nephrotoxicity of three of the most commonly used drug groups are reviewed in this article. They include antibiotics, radiocontrast agents, and nonsteroidal anti-inflammatory drugs. Since the clinical spectrum of drug-induced nephrotoxicity is broad, it is imperative that the clinician recognize these nephrotoxic syndromes while they are reversible with discontinuation of the offending drug.
Orthopaedic management of myelomeningocele: general orthopaedic management.
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Orthopaedic management of myelomeningocele: specific orthopaedic procedures.
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Chemical and functional correlates of postischemic renal ATP levels.
Renal energy metabolism was investigated before, during, and after ischemic insults of varying durations with in vivo 31P NMR spectroscopy. The postischemic recovery of renal ATP was found to be a biphasic process regardless of the length of the ischemia. This two-stage recovery consisted of a quick initial component immediately upon reflow followed by a slower, more gradual return toward preischemic levels. To characterize the source of each phase of the recovery, kidneys were extracted with perchloric acid at the end of the different periods of ischemia (before reflow). Concentrations of adenine nucleotides and breakdown products adenosine, inosine, and hypoxanthine were determined by 1H NMR spectroscopy. Excellent correlation was found between the residual nucleotide pool and the magnitude of the initial phase of ATP recovery. Additionally, the renal ATP content after 120 min of reflow was shown to have a strong correlation with subsequent functional recovery. These experiments show that in vivo 31P NMR can provide new and dynamic information concerning the biochemical recovery from ischemia. Furthermore, this data has the potential to predict the eventual functional recovery of the organ.