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Biomedical subjects

K Connolly

Publications and source records attributed to K Connolly.

At least 55 records · Page 3Linked to original sources
PubMed1985

The relationship between plasma fibronectin levels and autoimmune disease activity in MRL/l mice.

Plasma fibronectin levels increased significantly over time in MRL/l mice with progressive autoimmune disease. At 100 and 120 days of age both male and female MRL/l mice exhibited significantly higher fibronectin (Fn) levels than the more resistant MRL/l controls. Male mice at early time points had Fn levels no greater than controls due perhaps to the later onset of disease in MRL/l males. In contrast, female MRL/l mice, when compared with MRL/n controls, had higher Fn levels from 40 days of age. The proteinuria in these animals was also above MRL/n controls from the first time point taken (Day 40). In a temporal study with female MRL/l mice, Fn levels peaked at age 120 days and reflected the pattern of the survival curve, indicating that plasma Fn levels have an association with disease activity.

Aging↗
PubMed1985

Effect of disease modifying antirheumatic drugs and nonsteroidal antiinflammatory drugs upon cellular and fibronectin responses in a pleurisy model.

Intrapleural injections of carrageenan into rats resulted in peak increases in intrapleural inflammatory cell counts (90% mononuclear cells) and fibronectin content at 3 days after the injections. Administration of disease modifying antirheumatic drugs (DMARD) prevented the increases in both fibronectin levels and intrapleural cell counts, whereas nonsteroidal antiinflammatory drugs, in general, potentiated the increases. Inhibition of fibronectin production by DMARD in carrageenan induced pleurisy in rats may be related to the antirheumatic activity of this class of drugs.

Animals↗
PubMed1985

The effect of antiinflammatory drugs on plasma fibronectin.

When rats were injected with Freund's adjuvant to induce arthritis, systemic disease as measured by swelling of the noninjected paw, was paralleled by a 100% rise in plasma fibronectin as measured by electroimmunoassay. When arthritic rats were given daily oral doses of nonsteroidal antiinflammatory drugs (NSAID), swelling of the noninjected rear paw was significantly less than that of the untreated arthritic controls. However, in all cases, plasma fibronectin (Fn) levels remained high in drug treated arthritic rats. Whether the NSAID was aspirin (100 mg/kg), phenylbutazone (10, 30, or 100 mg/kg) or indomethacin (0.3, 1 or 3 mg/kg) the pattern remained the same--reduced paw volume and unchanged high plasma Fn levels. Fn levels also remained unaltered in normal animals treated with drugs alone. Though NSAID diminish inflammation, clinical studies have shown that they do not halt disease progression. Our report shows that NSAID also fail to alter production of high levels of plasma Fn.

Animals↗
PubMed1981

Maternal thyroid function and motor competence in the child.

Serum thyroid hormone levels were measured in women living in an area of severe dietary iodine deficiency in a remote region of Papua New Guinea. Levels of maternal hormone were found to be related to the motor competence of the women's offspring, who were aged between six years and 11 years 10 months at the time of assessment. Motor competence in the children was measured by two tests of manual dexterity which demanded speed and accuracy in performance. A significant correlation was obtained between the children's motor performance and maternal serum thyroxine levels, but not with maternal serum triiodothyronine levels. The implications of the findings for the pathogenesis of some forms of cerebral palsy are considered.

Child↗
PubMed1979

Rectal aspirin--absorption and antipyretic effect.

Rectal acetylsalicylic acid was given to 14 children who had undergone open heart surgery. The effect on their temperatures was similar whether 15--30 or 30--50 mg/kg was given. Either dose was more effective than no treatment. The greatest fall in temperature occurred after 4 or 5 hours. Rectal aspirin in a triglyceride base is effective in lowering postoperative temperature. It should also be of use in treating other fevers. A dose of 20--25 mg/kg is suggested.

Adolescent↗