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Biomedical subjects

K Clark

Publications and source records attributed to K Clark.

At least 181 records · Page 10Linked to original sources
PubMed1985

Clinical viral infections and multiple sclerosis.

Over an 8 year period, 170 patients with multiple sclerosis (MS) and 134 healthy controls were assessed at monthly intervals in order to ascertain environmental factors which might be important in producing exacerbation or progression of the illness, and to compare the frequency of common viral infections in the two groups. During cumulative periods designated "at risk" (2 weeks before the onset of infection until 5 weeks afterwards) annual exacerbation rates were almost 3-fold greater than those during periods not at risk. Approximately 9% of infections were temporally related to exacerbations, whereas 27% of exacerbations were related to infections. Frequency of common infections was approximately 20-50% less in MS patients than controls; it was progressively less in those with greater disability. Even in minimally disabled patients with similar potential for infectious contacts, the infection rate was significantly less than in controls, suggesting that MS patients could have superior immune defences against common viruses.

Adult↗
PubMed1982

Covariation between two-flash threshold and skin conductance level in first-breakdown schizophrenics: relationships in drug-free patients and effects of treatment.

Earlier research suggested that, compared with other individuals, schizophrenics show a different form of covariation between electrodermal level and perceptual discrimination, as indexed by the two-flash threshold. However, dispute has arisen as to whether previous contradictory results obtained on patient samples can be explained by a conventional inverted-U function or whether the relationship takes on an entirely different form, i.e., a U function. The latter alternative was confirmed here in a study of first-breakdown drug-free schizophrenics, tested on 3 consecutive days after hospital admission and before treatment began. However, the U function was evident only in the larger of two subgroups of schizophrenics, identified as patients whose treatment was delayed longer after admission, who were clinically less emotionally responsive and who, in basic personality, were more introverted. When the patients were subsequently tested during treatment, no systematic relationship between two-flash threshold and skin conductance could be discerned. The latter presumably reflected the fact that, during this phase of the experiment, there were marked and complex changes in the individual measures, the effects of treatment on which were briefly examined.

Adolescent↗
PubMed1981

Trauma as an etiologic and aggravating factor in multiple sclerosis.

We carried out a retrospective and prospective epidemiologic study designed to detect an association between trauma and multiple sclerosis in 130 patients and 82 age- and sex-matched controls. Electrical injury was followed by an increased frequency of exacerbation, which did not achieve statistical significance. There was no statistically significant association between other types of trauma and onset or deterioration of the disease. These findings do not prove that such an association cannot exist for any one individual patient; however, they do not provide evidence to support this idea.

Electric Injuries↗
PubMed1981

Infection.

Explore the source record for details and available documents.

Bacterial Infections↗
PubMed1978

Clinical studies of intrathecal autologous lymphocyte infusions in patients with malignant glioma: a toxicity study.

The feasibility and toxicity of intrathecal lymphoid cell infusions in patients with glioma were examined in this study. Blood rich in lymphoid cells was obtained using the Haemonetics Model 30 cell separator; the lymphoid cells extracted were further purified on Ficoll-Hypaque gradients. Four patients received a total of eighteen autologous lymphoid cell infusions, with between 1 X 10(6) and 5 X 10(9) lymphoid cells being infused on each occasion. No toxicity was observed, but the CSF glucose declined in 2 patients. In 1 patient examined at autopsy the lymphoid cells appeared to have gained access to the tumor bed as well as to the rest of the subarachnoid space.

Astrocytoma↗
PubMed1977

Transsphenoidal microsurgery for selective removal of functional pituitary microadenomas.

The transphenoidal approach to the pituitary gland is emerging as the safest and most efficacious procedure for the management of pituitary tumors. With the aid of the microscope large tumors producing visual symptoms can be removed and microadenomata producing only signs and symptoms of endocrinopathies can be safely and adequately approached. The procedure is described in this report. The results of its use in 29 patients with selected illustrative case reports are described.

Acromegaly↗
PubMed1977

Cerebral revascularization for transient ischemic attacks.

Thirty-one patients with cerebral transient ischemic, attacks and ipsilateral internal carotid artery occlusion without contralateral internal carotid artery occlusion or stenosis were treated with a surgical anastomosis between a superficial temporal artery and a cortical branch of the middle cerebral artery of the symptomatic hemisphere. The anastomosis was successful in 28 patients. Recurrent transient ischemic attacks were abolished in 23 patients and reduced in three. Two patients, one with a patent anastomosis, had strokes during the follow-up period. Of seven patients who refused the operation, two had strokes, two noted a reduction of transient ischemic attacks, two noted no change, and one became asymptomatic.

Adult↗
PubMed1977

Assessing adolescent mental health needs: the views of consumers, providers, and others.

The perceived mental health needs of adolescents were measured by questionnaire to groups of teenagers, parents, community child guidance personnel, self-help groups, police and court related people, school personnel, mental health administrators and area board members. Alcohol abuse and unemployment were seen as the first and second priority problems by most groups. Regarding specific services and facilities needed, residential facilities of various types were the most critical concern. Alcohol abuse programs, employment counseling, and family therapy and counseling were also major needs. There was considerable consensus as to needs among both consumers and providers. However, consumers tended to see as higher priority those problems affecting large numbers of adolescents while providers worried more about the seriously disturbed few.

Adolescent↗