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Biomedical subjects

K Chandramohan

Publications and source records attributed to K Chandramohan.

11 recordsLinked to original sources
PubMed2003

Unusual presentation of choriocarcinoma.

BACKGROUND: Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. The disease normally spreads to lung and brain. CASE REPORT: A case of malignant trophoblastic disease with brain metastasis, raised intra cranial pressure and small bowel metastasis presenting with acute abdomen is reported. CONCLUSIONS: Malignant transformation in a hydatidiform mole is rare event. Involvement of gastrointestinal tract is rarer even in presence of disseminated disease. Surgery is the treatment of choice for gastrointestinal complications.

Journal Article↗
PubMed2003

Metastatic osteosarcoma causing intussusception.

Osteosarcoma is the most common malignant bone neoplasm. It has a very high metastatic potential, and lungs are the most common site of metastasis followed by bones. Multiagent chemotherapy has been reported to alter the biological behavior of the disease so that the tumor metastasizes to more rare sites such as brain, bowel, and soft tissues. The authors report a case of jejuno-jejunal intussusception caused by metastases from osteosarcoma.

Bone Neoplasms↗
PubMed2003

Soft tissue sarcoma of the head and neck region in adults.

Soft tissue sarcomas (STS) are rare solid tumours accounting for less than 1% of all malignancies and are very unusual in the head and neck region. Histopathologically diagnosed cases of STS treated at Regional Cancer Centre (RCC). Trivandrum, India, between January 1989 and November 2000 were analyzed retrospectively. Survival analysis was carried out by Kaplan-Meier method and curves were compared using log rank test. A total of 22 cases were seen during the study period. The mean age of the patients was 36.4 years with male-to-female ratio of 2:1. The neck, lower jaw, tongue, cheek, scalp and maxilla were the commonest sites affected. None of the patients had palpable neck nodes or distant metastasis at presentation. All the patients were treated with primary surgical resection and this was followed by adjuvant treatment in 14 cases (63.6%). After a median follow-up of 14.5 months, two patients died, six developed local recurrence, four developed metastatic disease and another patient developed second primary sarcoma. The overall 5-year survival was 80% while the 5-year disease-free survival rate was 24.1%. The majority of the patients failed within first and second year. None of the parameters except grade of tumour (P=0.008) were found to have a significant effect on survival. The overall survival rate for patients with soft tissue sarcoma of the head and neck is good, however, disease-free survival is poor as the majority of these fail within 2 years of completing treatment.

Adolescent↗
PubMed2002

Carcinosarcoma of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcoma components.

We report a case of true malignant mixed tumour (carcinosarcoma) of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcomatous components in a 68-year-old woman. The pleomorphic sarcomatous component behaved aggressively with lymph node and distant metastases. The biological behaviour of the individual components in a malignant mixed tumour makes it difficult to diagnose. We could find no previous report of epithelial-myoepithelial carcinoma as a component of a carcinosarcoma of the parotid.

Aged↗
PubMed2002

An unusual bilateral cervical paraganglioma: a case report.

Paragangliomas are neoplasms originating from paraganglion tissue derived from mesoderm, the most common location being adjacent to carotid bifurcation. Rarely these tumours can be bilateral. We present here a case of bilateral paraganglioma occurring in a young woman. On one side the tumour was arising from the vagus nerve and on the other, from the carotid body. Clinical, radiological and histopathological features and treatment dilemmas are discussed.

Adult↗
PubMed1994

Testicular compensatory hypertrophy in the unilaterally adrenalectomized lizard Mabuya carinata (Schn.).

Unilateral adrenalectomy in recrudescent and breeding phases of the reproductive cycle caused atrophic changes in the ipsilateral testis, shown by inhibition of spermatogenic and steroidogenic activity of the ipsilateral testis. The contralateral testis showed compensatory hypertrophy. Unilateral adrenalectomy in regressing and quiescent phases of the reproductive cycle did not induce compensatory hypertrophy in the contralateral testis although there were atrophic changes in the ipsilateral testis.

3-Hydroxysteroid Dehydrogenases↗
PubMed1994

Effects of dexamethasone and gonadotropins on the testis of the adrenalectomized lizard Mabuya carinata (Schn.)

The effects of gonadotropins (LH + FSH) and dexamethasone on the spermatogenic and steroidogenic activity in the adrenalectomized Mabuya carinata have been studied. Secondary spermatocytes, spermatids, and spermatozoa were absent, and there was a significant decrease in the activity levels of delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSDH) and glucose-6-phosphate dehydrogenase in the adrenalectomized lizards compared with those of controls. Administration of either dexamethasone or LH + FSH to adrenalectomized lizards resulted in restoration of testicular activity as revealed by the appearance of secondary spermatocytes, spermatids, and spermatozoa and a significant increase in the activity level of delta 5-3 beta-HSDH compared to that of adrenalectomized lizards. The results indicate that impairment in gonadotropin secretion might be a major factor in inducing testicular regression following adrenalectomy in M. carinata.

3-Hydroxysteroid Dehydrogenases↗
PubMed1993

Testicular activity during different phases of reproductive cycle in the adrenalectomized lizard, Mabuya carinata (SCHN.).

The effects of bilateral adrenalectomy on the spermatogenetic and steroidogenic activity of the testis in different phases of the reproductive cycle of Mabuya carinata have been investigated. Adrenalectomy results in a significant decrease in the mean number of spermatogonia and primary spermatocytes, the diameters of the testis and tubule, and the activity levels of delta 5-3 beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase in recrudescent, breeding, regressing, and quiescent phases of the reproductive cycle when compared with those of controls. Further, secondary spermatocytes, spermatids, and spermatozoa were absent in the adrenalectomized lizards in all the phases of the cycle. The results indicate the involvement of the adrenals in the recrudescence and maintenance of testicular activity in M. carinata.

Adrenalectomy↗